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  • 1
    Online Resource
    Online Resource
    PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53–MDM2 loop
    Oxford University Press (OUP) ; 2011
    In:  Nucleic Acids Research Vol. 39, No. 6 ( 2011-3), p. 2234-2248
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 39, No. 6 ( 2011-3), p. 2234-2248
    Type of Medium: Online Resource
    ISSN: 1362-4962 , 0305-1048
    URL: Article
    DOI: 10.1093/nar/gkq1117
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2011
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 2
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    Mini‐open Pedicle Subtraction Osteotomy versus Standard Posterior Approach for Ankylosing Spondylitis‐related Spinal Kyphosis: A Comparative Study
    Wiley ; 2023
    In:  Orthopaedic Surgery Vol. 15, No. 10 ( 2023-10), p. 2656-2664
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 15, No. 10 ( 2023-10), p. 2656-2664
    Abstract: Surgical strategy for spinal kyphosis in patients with ankylosing spondylitis (AS) has been challenging. Pedicle subtraction osteotomy (PSO) through a minimally invasive (MI) approach has been developed with promising clinical outcomes. We aimed to compare the effectiveness and safety of PSO via an MI approach and a standard posterior approach (SPA) for treating AS‐related spinal kyphosis. Methods A total of 41 patients with AS‐related spinal kyphosis who underwent PSO through an MI approach (MI surgery [MIS] group: n = 25) or SPA (SPA group: n = 16) between January 2015 and July 2020 were retrospectively included. Spinopelvic parameters were evaluated before the surgery, immediately after the surgery, and at the 2‐year follow‐up. Clinical data including operative time, estimated blood loss, blood transfusion, level of fusion, incision length, bed rest period, length of hospitalization, and surgical complications were compared between the two groups. The Scoliosis Research Society outcomes instrument‐22 (SRS‐22) was administered to assess patients' quality of life at the latest follow‐up. Comparisons between the two groups were performed using independent sample t ‐test or Chi‐square test. Results Characteristics and baseline kyphosis of the two groups were matched. At the 2‐year follow‐up, in the MIS group, the average correction values of the sagittal vertical axis and global kyphosis (GK) were 9.5 cm and 44.3°, respectively. Compared with the SPA group, the MIS group had similar correction values and correction losses after surgery. No obvious differences were observed in any radiographic parameters, except for GK, immediately after surgery and at the 2‐year follow‐up between the two groups ( p   〉  0.05). The MIS group had a significantly shorter operative time, lesser blood loss, lesser transfusion volume, shorter fusion level, and lesser time to mobilization than did the SPA group. Higher average functional activity scores of SRS‐22 were obtained in the MIS group than in the SPA group. Conclusion Mini‐open PSO may be an effective alternative to the SPA for treating AS‐related spinal kyphosis, with comparable correction effect, lesser surgical trauma and faster recovery. This comparative study may provide valuable guidance for surgical decision‐making and patient counseling.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v15.10
    DOI: 10.1111/os.13873
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2483883-4
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  • 3
    Online Resource
    Online Resource
    Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor
    Springer Science and Business Media LLC ; 2022
    In:  Science China Life Sciences Vol. 65, No. 4 ( 2022-04), p. 718-730
    Details
    In: Science China Life Sciences, Springer Science and Business Media LLC, Vol. 65, No. 4 ( 2022-04), p. 718-730
    Type of Medium: Online Resource
    ISSN: 1674-7305 , 1869-1889
    URL: Article
    DOI: 10.1007/s11427-020-1744-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2546732-3
    detail.hit.zdb_id: 2133225-3
    SSG: 12
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  • 4
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    STARS: Spatial-Temporal Active Re-sampling for Label-Efficient Learning from Noisy Annotations
    Association for the Advancement of Artificial Intelligence (AAAI) ; 2023
    In:  Proceedings of the AAAI Conference on Artificial Intelligence Vol. 37, No. 9 ( 2023-06-26), p. 10980-10988
    Details
    In: Proceedings of the AAAI Conference on Artificial Intelligence, Association for the Advancement of Artificial Intelligence (AAAI), Vol. 37, No. 9 ( 2023-06-26), p. 10980-10988
    Abstract: Active learning (AL) aims to sample the most informative data instances for labeling, which makes the model fitting data efficient while significantly reducing the annotation cost. However, most existing AL models make a strong assumption that the annotated data instances are always assigned correct labels, which may not hold true in many practical settings. In this paper, we develop a theoretical framework to formally analyze the impact of noisy annotations and show that systematically re-sampling guarantees to reduce the noise rate, which can lead to improved generalization capability. More importantly, the theoretical framework demonstrates the key benefit of conducting active re-sampling on label-efficient learning, which is critical for AL. The theoretical results also suggest essential properties of an active re-sampling function with a fast convergence speed and guaranteed error reduction. This inspires us to design a novel spatial-temporal active re-sampling function by leveraging the important spatial and temporal properties of maximum-margin classifiers. Extensive experiments conducted on both synthetic and real-world data clearly demonstrate the effectiveness of the proposed active re-sampling function.
    Type of Medium: Online Resource
    ISSN: 2374-3468 , 2159-5399
    URL: Article
    DOI: 10.1609/aaai.v37i9.26301
    Language: Unknown
    Publisher: Association for the Advancement of Artificial Intelligence (AAAI)
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Distal Junctional Failures in Degenerative Thoracolumbar Hyperkyphosis
    Wiley ; 2024
    In:  Orthopaedic Surgery
    Details
    In: Orthopaedic Surgery, Wiley
    Abstract: Degenerative thoracolumbar hyperkyphosis (DTH) is a disease that negatively affects individual health and requires surgical intervention, yet the ideal surgical approach and complications, especially distal junctional failures (DJF), remain poorly understood. This study aims to investigate DJF in DTH and to identify the risk factors for DJF so that we can improve surgical decision‐making, and advance our knowledge in the field of spinal surgery to enhance patient outcomes. Methods This study retrospectively reviewed 78 cases (late osteoporotic vertebral compression fracture [OVCF], 51; Scheuermann's kyphosis [SK] , 17; and degenerative disc diseases [DDD], 10) who underwent corrective surgery in our institute from 2008 to 2019. Clinical outcomes were assessed using health‐related quality of life (HRQOL) measures, including the visual analogue scale (VAS) scores for back and leg pain, the Oswestry disability index (ODI), and the Japanese Orthopaedic Association (JOA) scoring system. Multiple radiographic parameters, such as global kyphosis (GK) and thoracolumbar kyphosis (TLK), were assessed to determine radiographic outcomes. Multivariate logistic regression analysis was employed to identify the risk factors associated with DJF. Results HRQOL improved, and GK, TLK decreased at the final follow‐up, with a correction rate of 67.7% and 68.5%, respectively. DJF was found in 13 of 78 cases (16.7%), two cases had wedging in the disc (L3‐4) below the instrumentation, one case had a fracture of the lowest instrumented vertebrae (LIV), one case had osteoporotic fracture below the fixation, nine cases had pull‐out or loosening of the screws at the LIV and three cases (23.1%) required revision surgery. The DJF group had older age, lower computed tomography Hounsfield unit (CT HU), longer follow‐up, more blood loss, greater preoperative sagittal vertical axis (SVA), and poorer postoperative JOA and VAS scores (back). The change in TLK level was larger in the non‐DJF group. Post‐sagittal stable vertebrae (SSV) moved cranially compared with pre‐SSV. Conclusion Age, CT HU, length of follow‐up, estimated blood loss, and preoperative SVA were independent risk factors for DJF. We recommend fixation of the two vertebrae below the apex vertebrae for DTH to minimize surgical trauma.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Article
    DOI: 10.1111/os.13973
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2483883-4
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  • 6
    Online Resource
    Online Resource
    Fatal H5N6 Avian Influenza Virus Infection in a Domestic Cat and Wild Birds in China
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-06-02)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-06-02)
    Abstract: H5N6 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired human H5N6 virus infection in 2014. Here, we report the first cases of fatal H5N6 avian influenza virus (AIV) infection in a domestic cat and wild birds. These cases followed human H5N6 infections in China and preceded an H5N6 outbreak in chickens. The extensive migration routes of wild birds may contribute to the geographic spread of H5N6 AIVs and pose a risk to humans and susceptible domesticated animals and the H5N6 AIVs may spread from southern China to northern China by wild birds. Additional surveillance is required to better understand the threat of zoonotic transmission of AIVs.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep10704
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
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  • 7
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    Online Resource
    Heparanase enhances nerve-growth-factor-induced PC12 cell neuritogenesis via the p38 MAPK pathway
    Portland Press Ltd. ; 2011
    In:  Biochemical Journal Vol. 440, No. 2 ( 2011-12-01), p. 273-282
    Details
    In: Biochemical Journal, Portland Press Ltd., Vol. 440, No. 2 ( 2011-12-01), p. 273-282
    Abstract: Heparanase is involved in the cleavage of the HS (heparan sulfate) chain of HSPGs (HS proteoglycans) and hence participates in remodelling of the ECM (extracellular matrix) and BM (basement membrane). In the present study we have shown that NGF (nerve growth factor) promoted nuclear enrichment of EGR1 (early growth response 1), a transcription factor for heparanase, and markedly induced heparanase expression in rat adrenal pheochromocytoma (PC12) cells. K252a, an antagonist of the NGF receptor TrkA (tyrosine kinase receptor A), decreased heparanase protein expression induced by NGF in PC12 cells. Suramin, a heparanase inhibitor, decreased heparanase in PC12 cells and blocked NGF-induced PC12 neuritogenesis. Stable overexpression of heparanase activated p38 MAPK (mitogen-activated protein kinase) by phosphorylation and enhanced the neurite outgrowth induced by NGF, whereas knock down of heparanase impaired this process. However, overexpression of latent pro-heparanase with a Y156A mutation still led to enhanced NGF-induced neurite outgrowth and increased p38 MAPK phosphorylation. Inhibition of p38 MAPK by SB203580 suppressed the promotion of NGF-induced neuritogenesis by the wild-type and mutant heparanase. The impaired differentiation by knock down of heparanase could be restored by transfection of wild-type or mutant heparanase in PC12 cells. The results of the present study suggest that heparanase, at least in the non-enzymatic form, may promote NGF-induced neuritogenesis via the p38 MAPK pathway.
    Type of Medium: Online Resource
    ISSN: 0264-6021 , 1470-8728
    URL: Article
    DOI: 10.1042/BJ20110167
    RVK:
    WA 15000
    Language: English
    Publisher: Portland Press Ltd.
    Publication Date: 2011
    detail.hit.zdb_id: 1473095-9
    SSG: 12
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  • 8
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    Online Resource
    A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53
    American Association for Cancer Research (AACR) ; 2018
    In:  Cancer Research Vol. 78, No. 13 ( 2018-07-01), p. 3484-3496
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 78, No. 13 ( 2018-07-01), p. 3484-3496
    Abstract: Long noncoding RNAs (lncRNA) have been associated with various types of cancer; however, the precise role of many lncRNAs in tumorigenesis remains elusive. Here we demonstrate that the cytosolic lncRNA P53RRA is downregulated in cancers and functions as a tumor suppressor by inhibiting cancer progression. Chromatin remodeling proteins LSH and Cfp1 silenced or increased P53RRA expression, respectively. P53RRA bound Ras GTPase-activating protein-binding protein 1 (G3BP1) using nucleotides 1 and 871 of P53RRA and the RRM interaction domain of G3BP1 (aa 177-466). The cytosolic P53RRA–G3BP1 interaction displaced p53 from a G3BP1 complex, resulting in greater p53 retention in the nucleus, which led to cell-cycle arrest, apoptosis, and ferroptosis. P53RRA promoted ferroptosis and apoptosis by affecting transcription of several metabolic genes. Low P53RRA expression significantly correlated with poor survival in patients with breast and lung cancers harboring wild-type p53. These data show that lncRNAs can directly interact with the functional domain of signaling proteins in the cytoplasm, thus regulating p53 modulators to suppress cancer progression. Significance: A cytosolic lncRNA functions as a tumor suppressor by activating the p53 pathway. Cancer Res; 78(13); 3484–96. ©2018 AACR.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/0008-5472.CAN-17-3454
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2018
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 9
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    Online Resource
    Aspartate transaminase/alanine transaminase (De Ritis ratio) predicts survival in major burn patients
    Elsevier BV ; 2022
    In:  Burns Vol. 48, No. 4 ( 2022-06), p. 872-879
    Details
    In: Burns, Elsevier BV, Vol. 48, No. 4 ( 2022-06), p. 872-879
    Type of Medium: Online Resource
    ISSN: 0305-4179
    URL: Article
    DOI: 10.1016/j.burns.2021.08.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2025040-X
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  • 10
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    Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality
    Proceedings of the National Academy of Sciences ; 2014
    In:  Proceedings of the National Academy of Sciences Vol. 111, No. 4 ( 2014-01-28)
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 111, No. 4 ( 2014-01-28)
    Abstract: Malaria infection triggers vigorous host immune responses; however, the parasite ligands, host receptors, and the signaling pathways responsible for these reactions remain unknown or controversial. Malaria parasites primarily reside within RBCs, thereby hiding themselves from direct contact and recognition by host immune cells. Host responses to malaria infection are very different from those elicited by bacterial and viral infections and the host receptors recognizing parasite ligands have been elusive. Here we investigated mouse genome-wide transcriptional responses to infections with two strains of Plasmodium yoelii (N67 and N67C) and discovered differences in innate response pathways corresponding to strain-specific disease phenotypes. Using in vitro RNAi-based gene knockdown and KO mice, we demonstrated that a strong type I IFN (IFN-I) response triggered by RNA polymerase III and melanoma differentiation-associated protein 5, not Toll-like receptors (TLRs), binding of parasite DNA/RNA contributed to a decline of parasitemia in N67-infected mice. We showed that conventional dendritic cells were the major sources of early IFN-I, and that surface expression of phosphatidylserine on infected RBCs might promote their phagocytic uptake, leading to the release of parasite ligands and the IFN-I response in N67 infection. In contrast, an elevated inflammatory response mediated by CD14/TLR and p38 signaling played a role in disease severity and early host death in N67C-infected mice. In addition to identifying cytosolic DNA/RNA sensors and signaling pathways previously unrecognized in malaria infection, our study demonstrates the importance of parasite genetic backgrounds in malaria pathology and provides important information for studying human malaria pathogenesis.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1316467111
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2014
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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