In:
Acupuncture & Electro-Therapeutics Research, Cognizant, LLC, Vol. 42, No. 3 ( 2017-07-01), p. 203-216
Abstract:
Restoration of blood flow to the ischemic myocardium termed reperfusion unavoidably leads to many heart complications (such as rhythm abnormalities, and sequentially heart failure), together with the induced damage of cardiomyocytes, which can worsen infarct size and is termed myocardial
ischemia-reperfusion (I/R) injury. Electroacupuncture plays an important role in attenuating I/R injury. High mobility group box-1 protein (HMGB1) is upregulated in myocardial I/R injury and activates the inflammatory response which enhances the myocardial injury. In our study, we aimed to detect the roles of electrical acupuncture at Neiguan acupoints (PC6) in myocardial I/R injury and investigate the relationship between electrical acupuncture and HMGB1-related pathway. We found that electrical acupuncture pretreatment protected against myocardial I/R injury through inhibiting
cell apoptosis. Electroacupuncture also decreased the expression levels of HMGB1 and inflammatory cytokines induced by I/R injury. In addition, the phosphorylation levels of JNK (c-Jun N-terminal kinase) was decreased by electroacupuncture in heart tissues. Furthermore, the effects of electrical acupuncture pretreatment were abrogated by the additional administration of recombinant HMGB1. Finally, the SP600125 administration, a selective JNK inhibitor, attenuated HMGB1-dependent cell apoptosis and cytokines release in myocardial I/R injury. In conclusion, our data demonstrate that
electrical acupuncture at PC6 plays a protective role in myocardial I/R injury, and this effect is associated with inhibited HMGB1-JNK pathway, which provides a beneficial therapeutic strategy for patients with myocardial I/R injury.
Type of Medium:
Online Resource
ISSN:
0360-1293
DOI:
10.3727/036012917X15118029263201
Language:
English
Publisher:
Cognizant, LLC
Publication Date:
2017
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