In:
JCR: Journal of Clinical Rheumatology, Ovid Technologies (Wolters Kluwer Health)
Abstract:
The purpose of this research was to ascertain the effectiveness of the newly established criteria for classifying IgG4-related disease (IgG4-RD), as applied to a large Chinese cohort in real-world clinical settings. Methods Patient data were procured from the digital health records of 4 prominent academic hospitals. The criterion standard for identifying IgG4-RD patients was from a seasoned rheumatologist. The control group consisted of individuals with other ailments such as cancer, other forms of pancreatitis, infectious diseases, and illnesses that mimic IgG4-RD. Results A total of 605 IgG4-RD patients and 760 mimickers were available for analysis. The 2019 EULAR/ACR criteria have a sensitivity of 69.1% and a specificity of 90.9% in this large Chinese cohort. IgG4-RD had a greater proportion of males (55.89% vs 36.25%, p 〈 0.001), an older average age at diagnosis (54.91 ± 13.44 vs 48.91 ± 15.71, p 〈 0.001), more pancreatic (29.59% vs 6.12%, p 〈 0.001) and salivary gland (63.30% vs 27.50%, p 〈 0.001) involvement, and a larger number of organ involvement (3.431 ± 2.054 vs 2.062 ± 1.748, p 〈 0.001) compared with mimickers. Conclusions The 2019 EULAR/ACR criteria are effective in classifying IgG4-RD in Chinese patients, demonstrating high specificity and moderate sensitivity.
Type of Medium:
Online Resource
ISSN:
1536-7355
,
1076-1608
DOI:
10.1097/RHU.0000000000002057
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2024
detail.hit.zdb_id:
2071025-2
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