In:
FEBS Letters, Wiley, Vol. 592, No. 14 ( 2018-07), p. 2444-2457
Abstract:
Parainfluenza virus infection is a common respiratory illness in children. Although lnc RNA s are novel regulators of virus‐induced innate immunity, a systemic attempt to characterize the differential expression of lnc RNA s upon parainfluenza virus infection is lacking. In this report, we identify 207 lnc RNA s and 166 mRNA s differentially expressed in SeV‐infected HEK 293T cells by microarray. The functional annotation analysis reveals that differentially regulated transcripts are predominantly involved in the host antiviral response pathway. The lnc RNA s with the potential to regulate SeV‐induced antiviral response are identified by building the lnc RNA ‐ mRNA coexpression network. Furthermore, silencing lnc RNA ENST 00000565297 results in reduced type I IFN signaling upon SeV infection. These catalogs may facilitate future analysis of the functions of lnc RNA s in innate immunity and related diseases.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1002/feb2.2018.592.issue-14
DOI:
10.1002/1873-3468.13166
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
212746-5
detail.hit.zdb_id:
1460391-3
SSG:
12
Permalink