In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 29, No. 6 ( 2014-06), p. 1223-1228
Abstract:
Prior studies have reported 2‐ L polyethylene glycol ( PEG ) plus ascorbic acid ( PEG + A sc) is an effective alternative to standard 4‐ L PEG for bowel preparation before colonoscopy, but they are limited because of some confounders. Therefore, we compared the efficacy, patient compliance, satisfaction, and safety of 2‐ L PEG + Asc versus 4‐ L PEG for bowel cleansing in optimal preparation strategies. Methods In this prospective, randomized, single‐blind trial, consenting outpatients were randomly assigned to one of two arms. All colonoscopies were scheduled in the morning and cleansing solutions were administered as a split‐dose regimen. Bowel‐cleansing efficacy in three different segments was measured on a five‐point scale with four‐point overall grading. Patients' opinions of the preparation regimens were obtained by questionnaire. Results There was no significant difference between the 2‐ L PEG + A sc (159/163; 97.5%) and 4‐ L PEG (162/164; 98.8%) with respect to the overall success of bowel cleansing (mean difference = −1.3 [−4.1–∞]). Patient compliance, acceptability, and satisfaction were better in the 2‐ L PEG + Asc arm than the 4‐L PEG arm ( P 〈 0.05). Additionally, the incidence of side effects was lower in the 2‐ L PEG + A sc than the 4‐ L PEG (overall, 57.7% vs 73.2%, P 〈 0.05). However, no significant difference was seen in patients' rating of taste. Conclusions In an optimal preparation setting, 2‐ L PEG + A sc has equal efficacy as a bowel cleanser prior to colonoscopy as 4‐ L PEG , with the advantages of better patient compliance, satisfaction, and safety.
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2014.29.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006782-3
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