In:
Angewandte Chemie International Edition, Wiley, Vol. 55, No. 25 ( 2016-06-13), p. 7068-7072
Abstract:
The first direct use of carbon dioxide in the lactamization of alkenyl and heteroaryl C−H bonds to synthesize important 2‐quinolinones and polyheterocycles in moderate to excellent yields is reported. Carbon dioxide, a nontoxic, inexpensive, and readily available greenhouse gas, acts as an ideal carbonyl source. Importantly, this transition‐metal‐free and redox‐neutral process is eco‐friendly and desirable for the pharmaceutical industry. Moreover, these reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.
Type of Medium:
Online Resource
ISSN:
1433-7851
,
1521-3773
DOI:
10.1002/anie.201602095
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2011836-3
detail.hit.zdb_id:
123227-7
Permalink