In:
Food & Function, Royal Society of Chemistry (RSC), Vol. 14, No. 17 ( 2023), p. 7853-7868
Abstract:
Background : Studies investigating the effects of dietary intake on serum uric acid (SUA) and hyperuricemia have yielded inconsistent results. Therefore, we conducted a meta-analysis to assess the associations between various dietary patterns and SUA levels as well as hyperuricemia. Methods : We searched PubMed, Web of Science, and EMBASE databases for relevant articles examining the association between dietary intake and SUA levels and/or hyperuricemia published until March 2023. Dietary intake patterns were classified into plant-based, animal-based, and mixed dietary patterns based on predominant foods. The pooled effect sizes of eligible studies and their corresponding 95% confidence intervals (CIs) were estimated using random-effects models. Publication bias was assessed using Egger's test. Results : We included 41 studies, comprising 359 317 participants, that investigated the effects of dietary patterns on SUA levels ( n = 25) and hyperuricemia ( n = 19). Our findings suggested that a plant-based dietary pattern was associated with decreased SUA levels in both interventional (standard mean difference: −0.24 mg dL −1 , 95% CI: −0.42, −0.06; I 2 = 61.4%) and observational studies (odds ratio (OR): 0.92, 95% CI: 0.89, 0.95, I 2 = 91.1%); this association was stronger in men (OR: 0.45, 95% CI: 0.35, 0.58; I 2 = 0). We observed that plant- and animal-based dietary patterns were associated with a reduced risk (OR: 0.75; 95% CI: 0.67, 0.83, I 2 = 93.3%) and an increased risk (OR: 1.38; 95% CI: 1.20, 1.59, I 2 = 88.4%) of hyperuricemia, respectively. Conclusions : Collectively, a plant-based dietary pattern is negatively associated with SUA levels and hyperuricemia. Therefore, a plant-based dietary pattern should be recommended for the management of SUA levels and the prevention of hyperuricemia.
Type of Medium:
Online Resource
ISSN:
2042-6496
,
2042-650X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
2578152-2
SSG:
21
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