In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-7), p. e0251011-
Abstract:
The clinical characteristics and therapeutic strategy in acute myeloid leukemia (AML) are influenced by patients’ age. We evaluated the impact of age on remission induction therapy for AML. Methods We retrospectively analyzed 3,011 adult AML patients identified from a nationwide database between January 2007 and December 2011. Results Three hundred twenty-nine (10.9%) acute promyelocytic leukemia (APL) and 2,682 (89.1%) non-APL patients were analyzed. The median age was 51 years and 55% of patients were male. Six hundred twenty-three patients (21%) were at favorable risk, 1522 (51%) were at intermediate risk, and 743 (25%) were at poor risk. As the age increased, the proportion of those at favorable risk and who received induction chemotherapy decreased. After induction therapy, complete response (CR) was achieved in 81.5% (243/298) of APL and 62.4% (1,409/2,258) of non-APL patients; these rates decreased as the age increased, with an obvious decrement in those older than 60 years. The median overall survival of non-APL patients was 18.7 months, while that of APL patients was not reached, with a 75% five-year survival rate. Conclusions Age impacts both the biology and clinical outcomes of AML patients. Further studies should confirm the role of induction remission chemotherapy by age group.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251011
DOI:
10.1371/journal.pone.0251011.g001
DOI:
10.1371/journal.pone.0251011.g002
DOI:
10.1371/journal.pone.0251011.g003
DOI:
10.1371/journal.pone.0251011.g004
DOI:
10.1371/journal.pone.0251011.g005
DOI:
10.1371/journal.pone.0251011.g006
DOI:
10.1371/journal.pone.0251011.t001
DOI:
10.1371/journal.pone.0251011.t002
DOI:
10.1371/journal.pone.0251011.s001
DOI:
10.1371/journal.pone.0251011.s002
DOI:
10.1371/journal.pone.0251011.s003
DOI:
10.1371/journal.pone.0251011.r001
DOI:
10.1371/journal.pone.0251011.r002
DOI:
10.1371/journal.pone.0251011.r003
DOI:
10.1371/journal.pone.0251011.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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