In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1240, No. 1 ( 2011-12), p. 7-13
Abstract:
Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Osteoclasts are primary cells for bone resorption, and their differentiation is tightly regulated by the receptor activator of nuclear factor κB ligand (RANKL) and a transcription factor nuclear factor–activated T cell (NFAT) c1. We found that RANKL‐induced NFATc1 expression is associated with the demethylation of H3K27me3. Jumonji domain containing‐3, a H3K27 demethylase, is induced in bone marrow–derived macrophages in response to RANKL stimulation and may play a critical role in the demethylation of H3K27me3 in the Nfatc1 gene.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2011.1240.issue-1
DOI:
10.1111/j.1749-6632.2011.06245.x
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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