In:
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society, Vol. 96, No. 5 ( 2011-05-01), p. E830-E835
Abstract:
Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear. Objective: We aimed to investigate the cross-sectional association of Vit-D status with brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in type 2 DM patients. Design, Setting, and Participants: We conducted a cross-sectional study of 280 patients (59% male, aged 68 ± 10 yr) with type 2 DM recruited in outpatient clinics during the winter period. Main Outcome Measure: We measured serum 25-hydroxyvitamin D [25(OH)D] by an ELISA kit, circulating CD34+/kinase insert domain-containing receptor (KDR)+ and CD133+/KDR+ EPCs by flow cytometry and brachial artery FMD by vascular ultrasound, respectively. Results: The mean serum 25(OH)D concentration was 25.00 ± 9.17 ng/ml, and 34.3% of patients had Vit-D deficiency [25(OH)D & lt; 20 ng/ml]. Serum 25(OH)D concentration had a significant correlation with hemoglobin A1c level [B = −0.018, 95% confidence interval (CI) −0.035 to −0.002, P = 0.032] . Patients with Vit-D deficiency status had significantly lower brachial FMD (mean difference −1.43%, 95% CI −2.31 to −0.55, P = 0.001) and CD133+/KDR+EPC counts (mean difference −0.12%, 95% CI −0.21 to −0.019, P = 0.022) than those with sufficient Vit-D status after adjustment for age, sex, and cardiovascular risk factors, including hemoglobin A1c levels. Conclusions: Our results demonstrate that serum 25(OH)D status was significantly associated with brachial artery FMD and circulating CD133+/KDR+EPCs. This suggests that Vit-D deficiency might contribute to depletion of EPCs and endothelial dysfunction in patients with type 2 DM.
Type of Medium:
Online Resource
ISSN:
0021-972X
,
1945-7197
DOI:
10.1210/jc.2010-2212
Language:
English
Publisher:
The Endocrine Society
Publication Date:
2011
detail.hit.zdb_id:
2026217-6
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