In:
BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
Abstract:
In this paper, a novel small-molecular apoptotic PET imaging probe, 18 F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, 18 F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2698540-8
Permalink