In:
Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-4-11)
Abstract:
Tibetans are one of the oldest ethnic groups in China and South Asia. Based on the analysis of 1,059 Tibetans in the Minjiang River basin at an altitude of 500–4,001 m, we found that the dominant phyla of the Tibetan population were Bacteroidota and Firmicutes , and the main genera were Prevotella and Bacteroides , which were mostly in consistent with other nationalities. We further evaluated in total 115 parameters of seven categories, and results showed that altitude was the most important factor affecting the variation in the microbial community. In the process of emigration from high altitudes to the plain, the gut microbial composition of late emigrants was similar to that of plateau aborigines. In addition, regarding immigration from low altitude to high altitude, the microbial community became more similar to that of high altitude population with the increase of immigration time. Changes in these microbes are related to the metabolism, disease incidence and cell functions of the Tibetan population. The results of other two cohorts (AGP and Z208) also showed the impact of altitude on the microbial community. Our study demonstrated that altitude of habitation is an important factor affecting the enterotype of the microflora in the Tibetan population and the study also provided a basis to explore the interaction of impact parameters with gut microbiome for host health and diseases.
Type of Medium:
Online Resource
ISSN:
1664-302X
DOI:
10.3389/fmicb.2022.834335
DOI:
10.3389/fmicb.2022.834335.s001
DOI:
10.3389/fmicb.2022.834335.s002
DOI:
10.3389/fmicb.2022.834335.s003
DOI:
10.3389/fmicb.2022.834335.s004
DOI:
10.3389/fmicb.2022.834335.s005
DOI:
10.3389/fmicb.2022.834335.s006
DOI:
10.3389/fmicb.2022.834335.s007
DOI:
10.3389/fmicb.2022.834335.s008
DOI:
10.3389/fmicb.2022.834335.s009
DOI:
10.3389/fmicb.2022.834335.s010
DOI:
10.3389/fmicb.2022.834335.s011
DOI:
10.3389/fmicb.2022.834335.s012
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2587354-4
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