In:
EMBO Molecular Medicine, EMBO, Vol. 15, No. 6 ( 2023-06-07)
Abstract:
image PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18. Exposure to PM2.5 activates EGFR pathway and promotes lung cancer progression. Long‐term exposure to PM2.5 increases lung cancer cell proliferation, anchorage‐independent growth, and xenograft tumor growth in mice. PM2.5 activates AhR to translocate into the nucleus and upregulates the expression of TMPRSS2. Depletion of TMPRSS2 in lung cancer cells suppresses anchorage‐independent growth and xenograft tumor growth in mice. TMPRSS2 upregulates IL I8 expression and promotes lung cancer progression.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.202217014
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2485479-7
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