In:
Organic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 10, No. 17 ( 2023), p. 4223-4229
Abstract:
Cyclopropenes are small and highly reactive compounds; however, their synthesis poses significant challenges. This study presents a novel synthetic route for producing a stable and versatile cyclopropene precursor. This approach effectively addresses the issues related to instability, low boiling points, and difficulties in scale-up processes. Additionally, the cyclopropene precursor enabled the easy synthesis of various cyclopropenes with different functional groups and handles. Among the synthesized cyclopropene derivatives, the 1-methylcyclopropene uracil nucleoside derivative 40 had the highest second-order kinetic constant when reacting with the 5-TAMRA-Tz fluorescent dye. Specifically, the kinetic constant reached a value of 56.6 ± 1.94 M −1 s −1 when measured in pure phosphate-buffered saline solution.
Type of Medium:
Online Resource
ISSN:
2052-4129
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
Permalink