In:
Allergy, Wiley, Vol. 74, No. 4 ( 2019-04), p. 675-684
Abstract:
The most relevant time of PM 10 exposure to affect airway hyperresponsiveness ( AHR ) and new development of asthma in school‐aged children is unclear. The aims of this study were to investigate the most critical time of PM 10 exposure to affect AHR and new diagnosis of asthma from AHR in school‐aged children. Methods Elementary schoolchildren (n = 3570) have been enrolled in a nationwide prospective 4‐year follow‐up survey in Korea from 2005 to 2006. Individual annual PM 10 exposure was estimated by using an ordinary kriging method from the prenatal period to 7 years of age. AHR at 7 years was defined by a methacholine PC 20 ≤8 mg/mL. Results PM 10 exposure during pregnancy and at 1 year of age showed significant effects on AHR ( aOR : 1.694, 95% CI : 1.298‐2.209; and aOR : 1.750, 95% CI : 1.343‐2.282, respectively). PM 10 exposure during pregnancy was associated with the risk of a new diagnosis of asthma ( aOR : 2.056, 95% CI : 1.240‐3.409), with the highest risk in children with AHR at age 7 ( aOR : 6.080, 95% CI : 2.150‐17.195). PM 10 exposure in the second trimester was associated with the highest risk of a new diagnosis of asthma in children with AHR at age 7 ( aOR : 4.136, 95% CI : 1.657‐10.326). Conclusions Prenatal PM 10 exposure in the second trimester is associated with an increased risk of a new diagnosis of asthma in school‐aged children with AHR at 7 years. This study suggests that PM 10 exposure during a specific trimester in utero may affect the onset of childhood asthma via AHR .
Type of Medium:
Online Resource
ISSN:
0105-4538
,
1398-9995
DOI:
10.1111/all.2019.74.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2003114-2
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