In:
New Journal of Chemistry, Royal Society of Chemistry (RSC), Vol. 47, No. 23 ( 2023), p. 10921-10929
Abstract:
Membrane-active amphiphilic β-cyclodextrin derivatives with poly-amino groups and an alkyl chain tail were created as anti-microbial peptide polymyxins. Although the molecule is relatively hydrophilic, the hydrophobic chain tail attached locally on the β-cyclodextrin molecule disrupted the bacterial membrane without destroying the animal cell, resulting in the avoidance of unfavourable hemolytic activity against red blood cells and the achievement of selective anti-bacterial activity.
Type of Medium:
Online Resource
ISSN:
1144-0546
,
1369-9261
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
1472933-7
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