In:
Journal of Arrhythmia, Wiley, Vol. 34, No. 4 ( 2018-08), p. 428-434
Abstract:
Oral anticoagulants, including direct oral anticoagulants ( DOAC s), are usually required in atrial fibrillation ( AF ) patients who are at a high risk of thromboembolism ( TE ), even if they had undergone catheter ablation ( CA ). Although several studies have reported the safety and efficacy of DOAC s around CA in AF patients, there are only limited data regarding the midterm incidence of TE and bleeding complications post‐ CA among AF patients treated with warfarin or DOAC s. Methods We studied 629 AF patients (mean age: 65.3 ± 10.3 years; 442 men) undergoing CA , to calculate the midterm incidence of TE and bleeding complications associated with warfarin or DOAC s. Results In total, 292 patients used warfarin and 337 used DOAC s (dabigatran: 90 patients; rivaroxaban: 137; and apixaban: 110). At baseline, the CHA 2 DS 2‐ VAS c and HAS ‐ BLED scores were similar between the 2 groups. During a median follow‐up period of 7 months, no TE complications occurred. The warfarin group had a significantly higher bleeding event rate than did the DOAC s group (all bleeding complications: 32 [11.0%] vs 15 [4.5%] , respectively, P = .002). The rate of all bleeding complications was significantly higher in the warfarin group than in the DOAC s group (10.1% vs 3.7%, respectively, at 10 months; P = .024). In Cox proportional hazards modeling, DOAC use was significantly associated with a decreased risk of bleeding (adjusted hazard ratio: 0.497; 95% confidence interval: 0.261‐0.906, P = .022). Conclusions Direct oral anticoagulant use in AF patients undergoing CA may be associated with a similar risk of TE as warfarin but is associated with a lower risk of bleeding.
Type of Medium:
Online Resource
ISSN:
1880-4276
,
1883-2148
DOI:
10.1002/joa3.2018.34.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2696593-8
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