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  • 1
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    Online Resource
    Prognostic score to predict time to castration-resistance in underserved patients with metastatic prostate cancer.
    American Society of Clinical Oncology (ASCO) ; 2017
    In:  Journal of Clinical Oncology Vol. 35, No. 15_suppl ( 2017-05-20), p. e16518-e16518
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 35, No. 15_suppl ( 2017-05-20), p. e16518-e16518
    Abstract: e16518 Background: This study aimed to identify predictors of time to castration-resistance prostate cancer (tCRPC) from initial diagnosis of metastatic prostate cancer (mPC) and develop a prognostic score in the underserved population of an inner-city tertiary care hospital. Methods: We retrospectively reviewed charts of 278 men diagnosed with mPC between 2001 and 2015, of which 155 patients were analyzed. Socio-demographic, clinical and pathologic factors were ascertained at the time of diagnosis. Kaplan-Meier and cox regression analyses were done to explore correlates tCRPC. Crude (HR) and adjusted (aHR) hazard ratios with 95% confidence intervals (CI) were obtained. Results: Over a median follow-up of 46 months (95% CI 23-69), 73.5% of men developed castration-resistance. Median tCRPC was 16 months (95% CI 12.5-19.5). All patients received medical or surgical castration at the time of diagnosis. Significant correlates of short tCRPC included: prostate specific antigen 〉 20 ng/mL (HR 2.56, 95% CI 1.25-5.23, P=0.010), core involvement 〉 50% (HR 2.11, 95% CI 1.43-3.11, P 〈 0.001), bone metastases (HR 2.94, 95% CI 1.36-6.35, P=0.006), visceral metastases (HR 01.65, 95% CI 1.08-2.53, P=0.021), hemoglobin 〈 10 g/dL (HR 2.02, 95% CI 1.26-3.23, P=0.003), alkaline phosphatase (ALP) 〉 240 U/L (HR 2.42, 95% CI 1.62-3.61, P 〈 0.001), lactate dehydrogenase (LDH) 〉 200 U/L (HR 1.68, 95% CI 1.16-2.43, P=0.006) and neutrophil-lymphocyte ratio 〉 2.4 (HR 1.50, 95% CI 1.03-2.20, P=0.035). In multivariate model, core involvement 〉 50% (aHR 2.99, 95% CI 1.79-5.01, P 〈 0.001), ALP 〉 240 U/L (aHR 2.08, 95% CI 1.13-3.84, P=0.019) and LDH 〉 200 U/L (aHR 1.71, 95% CI 1.02-2.86, P=0.043) independently predicted short tCRPC and each factor decreased tCRPC by almost 50%. Mean prognostic score (PS), based on 1 point for each independent predictor (scale 0-3), was 1.23 (SD 0.91) and significantly predicted short tCRPC (P 〈 0.001). [Table] Conclusions: Our PS based on core involvement ( 〉 50%), high ALP ( 〉 240 U/L) and high LDH ( 〉 200 U/L) significantly predicts tCRPC in men with mPC. Prospective studies are warranted to further validate this score. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2017.35.15_suppl.e16518
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2017
    detail.hit.zdb_id: 2005181-5
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  • 2
    Online Resource
    Online Resource
    Predicting response to neoadjuvant chemotherapy in nonmetastatic hormone receptor-positive breast cancer using 21-gene Breast Recurrence Score test.
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. e12093-e12093
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. e12093-e12093
    Abstract: e12093 Background: The Recurrence Score (RS) result based on the 21-gene Oncotype DX Breast Recurrence Score assay is standard of care in deciding adjuvant chemo-hormonal therapy versus hormone therapy alone in hormone-receptor positive (HR+), HER 2 negative, node–negative breast cancer. This study explores the role of RS result in predicting the response to neoadjuvant chemotherapy (NACT). Methods: In this retrospective single institution cohort study, electronic medical records of 148 women with HR+, HER 2 negative, non-metastatic breast cancer who received NACT from 2006 onward were screened. 38 patients were excluded due to lack of tissue for testing. Pretreatment biopsy blocks were sent to Genomic Health, Inc. for Oncotype Dx testing. Low RS result was defined as ≤25. Pathologic complete response (pCR) was defined as no residual tumor. Partial response (PR) was residual tumor with 〉 25% decrease in the largest dimension. No response (NR) was defined as 〈 25% decrease in the tumor post NACT. Progression (PD) was defined as increase in size of original tumor or new site(s) of disease. Results: Of the 110 patients studied, 58% were postmenopausal women. Fifty percent were African American, 12% were Caucasian and 27% were Hispanic. Invasive ductal carcinoma was the predominant histology (86%). Most patients had 〉 T2 disease (97%) with 73% being clinically node positive. Adriamycin based NACT regimen was used in treating 86.3% of the women. Forty patients (36.4%) had tumor with RS≤25. NR/PD was significantly higher in tumors with RS≤25 (27/40) vs RS 〉 25 (13/70) (OR: 9.1, 95% CI: 3.7-22.2, P 〈 0.001). pCR was seen in 16% with RS 〉 25 and 0% with RS ≤25. Response to NACT (pCR/PR) was 32.5% in RS≤25 vs 81.4% in RS 〉 25. In tumors with response, RS 〉 25 was associated with a greater percent decrease in the tumor size compared to RS≤25 (median decrease of 71% vs 52%, P= 0.033). Conclusions: HR+, HER 2 negative, RS≤25 breast cancer is associated with increased rates of NR/PD and is unlikely to respond to NACT. Recurrence Score result determination in pretreatment breast cancer biopsy samples can be an effective tool to select patients with non-metastatic breast cancer for NACT. Studies are needed to determine novel neoadjuvant therapeutic approaches in patients who are candidates for neoadjuvant therapy but are unlikely to benefit from NACT.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2019.37.15_suppl.e12093
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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  • 3
    Online Resource
    Online Resource
    Effect of Trichoderma koningiopsis on Chickpea Rhizosphere Activities under Different Fertilization Regimes
    Scientific Research Publishing, Inc. ; 2018
    In:  Open Journal of Soil Science Vol. 08, No. 10 ( 2018), p. 261-275
    Details
    In: Open Journal of Soil Science, Scientific Research Publishing, Inc., Vol. 08, No. 10 ( 2018), p. 261-275
    Type of Medium: Online Resource
    ISSN: 2162-5360 , 2162-5379
    URL: Article
    DOI: 10.4236/ojss.2018.810020
    Language: Unknown
    Publisher: Scientific Research Publishing, Inc.
    Publication Date: 2018
    detail.hit.zdb_id: 2679778-1
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  • 4
    Online Resource
    Online Resource
    Diagnosis of alternaria diseases on underground vegetable crops
    Diva Enterprises Private Limited ; 2021
    In:  Annals of Plant Protection Sciences Vol. 29, No. 1 ( 2021), p. 51-57
    Details
    In: Annals of Plant Protection Sciences, Diva Enterprises Private Limited, Vol. 29, No. 1 ( 2021), p. 51-57
    Type of Medium: Online Resource
    ISSN: 0971-3573 , 0974-0163
    URL: Article
    DOI: 10.5958/0974-0163.2021.00009.4
    Language: English
    Publisher: Diva Enterprises Private Limited
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Impact of Cytogenetic Abnormalities on the Risk of Disease Progression in Solitary Bone Plasmacytomas
    American Society of Hematology ; 2023
    In:  Blood Journal ( 2023-07-26)
    Details
    In: Blood Journal, American Society of Hematology, ( 2023-07-26)
    Abstract: Most patients with SBP progress to MM after definitive radiation therapy as their primary treatment. Whether the presence of high-risk (HR) cytogenetic abnormalities by FISH in the clonal plasma cells, obtained either directly from the diagnostic SBP tissue or the corresponding bone marrow examination at the time of diagnosis, is associated with a shorter time to progression (TTP) to MM is unknown. This study evaluated all patients diagnosed with SBP at the Mayo Clinic from January 2012 to July 2022. The presence of del(17p), t(14;16), t(4;14), or +1q (gain or amplification) by FISH in clonal plasma cells was defined as HR. A total of 114 patients were included in this cohort, and baseline FISH was available for 55 patients (48%), of which 22 were classified as HR (40%). The median TTP to MM for patients with SBP and HR FISH was 8 months (95%CI: 6.3-26) compared to 42 months (95%CI: 25-NR) in patients with SBP without HR FISH (p & lt;0.001). In a multivariate analysis, only HR FISH was a significant predictor for shorter TTP to MM, independent of minimal marrow involvement and an abnormal serum free light chain (sFLC) ratio at diagnosis. Deletion (17p) and +1q abnormalities were the most common FISH abnormalities responsible for the short TTP to MM. Thus, assessing for HR FISH abnormalities in clonal plasma cells derived from either the diagnostic SBP tissue or the staging bone marrow examination of patients with newly diagnosed SBP is feasible and prognostic for a shorter TTP to MM.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.2023021187
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2023
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 6
    Online Resource
    Online Resource
    Upfront docetaxel for castration-sensitive metastatic prostate cancer in an ethnically diverse inner-city population.
    American Society of Clinical Oncology (ASCO) ; 2018
    In:  Journal of Clinical Oncology Vol. 36, No. 15_suppl ( 2018-05-20), p. e17038-e17038
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 36, No. 15_suppl ( 2018-05-20), p. e17038-e17038
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2018.36.15_suppl.e17038
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2018
    detail.hit.zdb_id: 2005181-5
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  • 7
    Online Resource
    Online Resource
    Predictors and outcomes of thyroid dysfunction with immunotherapy: A single institution observational experience.
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. e14134-e14134
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. e14134-e14134
    Abstract: e14134 Background: Immune-related endocrine dysfunction is unique to immunotherapy (IT). We aimed to explore the clinical parameters associated with development of thyroid disorder (TD) in patients receiving IT and their outcome. Methods: We designed a retrospective study of patients treated with anti-CTLA4 and/or anti-PD1/PDL1 IT at Cook County Hospital, Chicago between January 2015 to January 2018. Patients with incomplete charts and those who received less than two cycles of IT were excluded. Demographics, clinical and pathologic data were recorded at the time of diagnosis and prior to start of IT. Pearson Chi-square, independent sample t-test and logistic regression were used for data analysis. Results: We included 104 patients in the study, out of whom 66 were male and 38 were female. Most common diagnosis was non-small cell lung cancer (42.4%) followed by squamous cell cancer of head and neck (21.2%), renal cell cancer (12.5%), small cell lung cancer (12.5%) and melanoma (8.7%). Majority of patients (91.4%) had metastasized and were treated with either Nivolumab (71.1%) or Pembrolizumab (21.2%) in the 2 nd (50%) or 3 rd line (29.8%) setting. Twenty-eight patients developed TD while on IT, out of whom, 13 developed hypothyroidism, 12 developed hyperthyroidism followed by hypothyroidism and 3 developed hyperthyroidism. TD developed between 1 st to 6 th cycle of IT in 96.5% patients. Older age (p-0.009), history of radiation (RT) to neck (p-0.007), history of RT to chest (p-0.015), history of venous thrombosis (p-0.007) and higher thyroid stimulating hormone (TSH) level (17.76±35.67) prior to starting IT (p-0.029) were significantly associated with TD. Multivariate logistic regression showed that history of RT to neck was a significant predictor of developing TD after adjustment for age, race and sex (adjusted OR 9.64, 95% CI 1.88-49.36, p-0.007). No patient reported thyroid related symptom and IT was continued uninterrupted in all patients. Levothyroxine was the drug of choice for treating hypothyroidism. No patient received steroids or antithyroid medications. Conclusions: History of radiation therapy to neck is significantly associated with development of thyroid dysfunction in patients receiving immunotherapy. Thyroid replacement therapy is sufficient to bring down the levels of TSH and immunotherapy need not be interrupted.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2019.37.15_suppl.e14134
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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  • 8
    Online Resource
    Online Resource
    Design and Simulation of low cost Root Crop Harvester
    Walter de Gruyter GmbH ; 2019
    In:  Open Agriculture Vol. 4, No. 1 ( 2019-01-01), p. 139-143
    Details
    In: Open Agriculture, Walter de Gruyter GmbH, Vol. 4, No. 1 ( 2019-01-01), p. 139-143
    Abstract: In India agriculture is one of the most important sources of employment for the farmers and almost everything depends on agriculture. Root vegetables and crops are hard to remove from the soil and it takes much of the farmer’s time. Even after removing these crops manually farmers are not able to achieve 100% recovery of the crops. When these crops are taken out manually this process require many precautions from the farmer. Due to human error approximate 20-30% of root vegetables and crops are left out in the field. Rich farmers can afford the proper machinery to cultivate the root crops but poor farmers are not able to afford such types of machinery. Hence, the objective of the present study was to design and simulate low cost root crop harvesting machines for poorer farmers. The machine consists of a frame, chain drive, gears, shaft, seed drill ground wheel, plough and storage container. All the measurements, dimensions and material selections were taken as per ASTM-A36 and the design hand data book. The design of the Root Crop Harvester was done mathematically and finally validated using CAD software.
    Type of Medium: Online Resource
    ISSN: 2391-9531
    URL: Article
    DOI: 10.1515/opag-2019-0013
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2019
    detail.hit.zdb_id: 2864636-8
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  • 9
    Online Resource
    Online Resource
    Comparison of the Quality of Various Sources of Drinking Water Available in Mathura, Uttar Pradesh
    ScopeMed ; 2017
    In:  International Journal of Livestock Research ( 2017), p. 1-
    Details
    In: International Journal of Livestock Research, ScopeMed, ( 2017), p. 1-
    Type of Medium: Online Resource
    ISSN: 2277-1964
    URL: Journal
    URL: Article
    DOI: 10.5455/ijlr.
    DOI: 10.5455/ijlr.20170624053553
    Language: Unknown
    Publisher: ScopeMed
    Publication Date: 2017
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  • 10
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    Online Resource
    ​Estimation of Genetic Variability and Genetic Divergence in Dolichos Bean [Lablab purpureus (L.) Sweet.] Genotypes
    Agricultural Research Communication Center ; 2021
    In:  LEGUME RESEARCH - AN INTERNATIONAL JOURNAL , No. Of ( 2021-8-2)
    Details
    In: LEGUME RESEARCH - AN INTERNATIONAL JOURNAL, Agricultural Research Communication Center, , No. Of ( 2021-8-2)
    Abstract: Background: Dolichos bean is an important leguminous vegetable having a wide range of variation in different quantitative characters. Assessing genetic diversity among dolichos bean accessions can ensure development of suitable high-yielding and adapted varieties with suitable maturity period. Methods: Fifteen genotypes were evaluated for different characters in Dolichos bean at two locations of Dr. Rajendra Prasad Central Agricultural University viz. Vegetable Research Farm, Pusa and Krishi Vigyan Kendra, Birauli, Samastipur, Bihar during the year 2018-19 and pooled data was analyzed. The genotypes were evaluated for genetic variability and genetic divergence for 14 characters. For the assessment of genetic diversity among the fifteen genotypes of dolichos bean, Mahalanobis (D2) statistic (Mahalanobis, 1936) was used, following the procedure given by Rao, 1952. Grouping of genotypes into clusters was done using Tocher’s method as described by Rao, 1952. Result: Phenotypic Coefficient of Variation (PCV) was slightly higher than Genotypic Coefficient of Variation (GCV) for all the characters indicated that the characters were less influenced by environment. The characters having high heritability and high genetic advance include harvesting duration, number of pods per plant, pod length, pod diameter, individual pod weight, weight of seeds per pod, 100 fresh green seed weight, pod yield and percent incidence of yellow mosaic virus. Therefore, selection for above characters is highly effective. Genetic diversity analysis evaluated that all genotypes could be placed into 6 clusters. Genotypes grouped in Cluster III and I have highest mean value for all characters as well as highest inter-cluster distance.
    Type of Medium: Online Resource
    ISSN: 0976-0571 , 0250-5371
    URL: Article
    DOI: 10.18805/LR-4626
    Language: Unknown
    Publisher: Agricultural Research Communication Center
    Publication Date: 2021
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