In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
Abstract:
Background: Malnutrition and inflammation are associated with poor outcomes with heart failure (HF). It has been reported that Advanced Lung cancer Inflammation index (ALI), calculated by body mass index х serum albumin level / neutrophil to lymphocyte ratio (NLR) can be used for the prognosis assessment of various malignancies. In addition, it has been reported to be useful as a prognostic factor in HF patients. Then, we sought to clarify the prognostic value of ALI in patients with HF with preserved ejection fraction (HFpEF). Methods and Results: Patients’ data were extracted from The Prospective mUlticenteR obServational stUdy of patIenTs with Heart Failure with Preserved Ejection Fraction (PURSUIT HFpEF) study, which is a prospective multicenter observational registry for ADHF-HFpEF in Osaka. Laboratory data and body weight measurements were performed just before discharge. We analyzed 821 patients (mean age: 81 years old, male: 45%) after exclusion of patients on dialysis, in-hospital death, missing follow-up data, or missing data to calculate ALI. The primary endpoint of the present study was all-cause death (ACD). During a mean follow-up period of 1.8±1.0 years, 169 patients died. In multivariate Cox analysis, ALI was significantly associated with ACD independently of age, serum sodium level, hemoglobin level, and serum NT-proBNP level after adjustment for sex, NYHA functional class, systolic blood pressure, serum creatinine level, serum CRP level, past medical history of AF and LVEF. By ROC curve analysis, AUC of ALI was significantly greater than that of NLR. Kaplan-Meier curve analysis revealed that patients with lowest ALI (24.16 ≥ ALI categorized by tertile) had higher risk of ACD than those with highest ALI (ALI 〉 40.10) (32% vs 13%, adjusted HR 2.93. 95%CI [2.01-4.38] , p 〈 0.0001). Conclusion: ALI, a systemic inflammation-nutrition index, might be useful for stratifying ADHF patients with HFpEF at risk for the total mortality.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.144.suppl_1.10205
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
1466401-X
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