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  • 1
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    supp1-3254155.pdf
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Evolutionary Computation Vol. 27, No. 4 ( 2023-8), p. 802-816
    Details
    In: IEEE Transactions on Evolutionary Computation, Institute of Electrical and Electronics Engineers (IEEE), Vol. 27, No. 4 ( 2023-8), p. 802-816
    Type of Medium: Online Resource
    ISSN: 1089-778X , 1089-778X , 1941-0026
    URL: Article
    URL: Article
    DOI: 10.1109/TEVC.2023.3254155
    DOI: 10.1109/TEVC.2023.3254155/mm1
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
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    SSG: 11
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  • 2
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    NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases
    Elsevier BV ; 2022
    In:  Nano Today Vol. 43 ( 2022-04), p. 101447-
    Details
    In: Nano Today, Elsevier BV, Vol. 43 ( 2022-04), p. 101447-
    Type of Medium: Online Resource
    ISSN: 1748-0132
    URL: Article
    DOI: 10.1016/j.nantod.2022.101447
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 3
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    DataSheet1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-6-15)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-6-15)
    Abstract: Introduction: Usnic acid (UA) and barbatic acid (BA), two typical dibenzofurans and depsides in lichen, have a wide range of pharmacological activities and hepatotoxicity concerns. This study aimed to clarify the metabolic pathway of UA and BA and illuminate the relationship between metabolism and toxicity. Methods: An UPLC-Q-TOF-MS method was developed for metabolite identification of UA and BA in human liver microsomes (HLMs), rat liver microsomes (RLMs), and S9 fraction (RS9). The key metabolic enzymes responsible for UA and BA were identified by enzyme inhibitors combined with recombinant human cytochrome P450 (CYP450) enzymes. The cytotoxicity and metabolic toxicity mechanism of UA and BA were determined by the combination model of human primary hepatocytes and mouse 3T3 fibroblasts. Results: The hydroxylation, methylation, and glucuronidation reactions were involved in the metabolic profiles of UA and BA in RLMs, HLMs, and RS9. CYP2C9, CYP3A4, CYP2C8, and UGT1A1 are key metabolic enzymes responsible for metabolites of UA and CYP2C8, CYP2C9, CYP2C19, CYP1A1, UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 for metabolites of BA. UA and BA did not display evident cytotoxicity in human primary hepatocytes at concentrations of 0.01–25 and 0.01–100 µM, respectively, but showed potential cytotoxicity to mouse 3T3 fibroblasts with 50% inhibitory concentration values of 7.40 and 60.2 µM. Discussion: In conclusion, the attenuated cytotoxicity of BA is associated with metabolism, and UGTs may be the key metabolic detoxification enzymes. The cytotoxicity of UA may be associated with chronic toxicity. The present results provide important insights into the understanding of the biotransformation behavior and metabolic detoxification of UA and BA.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2023.1207928
    DOI: 10.3389/fphar.2023.1207928.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
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    SSG: 15,3
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  • 4
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    Effects of continuous and slow tracheal tube cuff deflation on cough reflex during extubation in noncardiac surgery patients: a randomised clinical trial
    Springer Science and Business Media LLC ; 2023
    In:  BMC Anesthesiology Vol. 23, No. 1 ( 2023-02-07)
    Details
    In: BMC Anesthesiology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-02-07)
    Abstract: The incidence of cough reflex during extubation is 76%. Cough reflex causes severe hemodynamic fluctuations and airway complications. This prospective trial investigated the potential effects of tracheal tube cuff deflation on cough reflex during extubation. Methods One hundred and twenty-six patients scheduled for operations within 3 h under general anaesthesia with orotracheal intubation were randomly assigned to one of three groups: control (C), experimental (E) or syringe (S) groups. Patients in group C underwent tracheal tube cuff deflation using a 10-ml syringe in 1 s, patients in group E underwent tracheal tube cuff deflation continuously and slowly in 5 s using a cuff pressure gauge until the pressure was zero and patients in group S underwent tracheal tube cuff deflation using a 10-ml syringe at a speed of 1 ml s −1 . The incidence and severity of cough reflexs during extubation and the incidence of postoperative airway complications within 48 h were assessed. Results Compared with group C (60.0%), the incidence of cough reflex in group E was 9.8% ( p   〈  0.001) and in group S was 12.5% ( p   〈  0.001). The severity of cough reflex was graded as 2 (1–2) in group C, 1 (1–1) in group E and 1 (1–1) in group S ( p   〈  0.001 for group comparisons). The incidence of hoarseness in group C was 0.0%, in group E was 19.5% and in group S was 5.0% ( p   〈  0.05 for all groups, p  = 0.009 between group C and E). Conclusions Compared with deflating a trachal tube cuff with a 10-ml syringe in 1 s, the use of a 10-ml syringe at a speed of 1 ml s −1 or a cuff pressure guage within 5 s can both reduce the incidence of cough reflex, but deflating with a cuff pressure guage can increase the incidence of postoperative hoarseness. Trial registration Chinese Clinical Trial Registry, identifier: ChiCTR2100054089, Date: 08/12/2021.
    Type of Medium: Online Resource
    ISSN: 1471-2253
    URL: Article
    DOI: 10.1186/s12871-023-02003-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2091252-3
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  • 5
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    Online Resource
    Multiobjective optimization algorithm with dynamic operator selection for feature selection in high-dimensional classification
    Elsevier BV ; 2023
    In:  Applied Soft Computing Vol. 143 ( 2023-08), p. 110360-
    Details
    In: Applied Soft Computing, Elsevier BV, Vol. 143 ( 2023-08), p. 110360-
    Type of Medium: Online Resource
    ISSN: 1568-4946
    URL: Article
    DOI: 10.1016/j.asoc.2023.110360
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2057709-6
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  • 6
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    NIR Responsive Nitric Oxide Nanogenerator for Enhanced Biofilm Eradication and Inflammation Immunotherapy Against Periodontal Diseases
    Elsevier BV ; 2021
    In:  SSRN Electronic Journal
    Details
    In: SSRN Electronic Journal, Elsevier BV
    Type of Medium: Online Resource
    ISSN: 1556-5068
    URL: Article
    DOI: 10.2139/ssrn.3958969
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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  • 7
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    Risk factors for delayed recovery in postanesthesia care unit after surgery: a large and retrospective cohort study
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  International Journal of Surgery Vol. 109, No. 5 ( 2023-04-20), p. 1281-1290
    Details
    In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 109, No. 5 ( 2023-04-20), p. 1281-1290
    Abstract: Delayed recovery in the postanesthesia care unit (PACU) after surgery, as a severe occurrence, influences enhanced recovery after surgery. The data from the observational clinical study is a paucity. Materials and Methods: This large, retrospective, and observational cohort study initially included 44 767 patients. The primary outcome was risk factors for delayed recovery in PACU. A generalized linear model and nomogram were employed to identify risk factors. Discrimination and calibration were used to evaluate the performance of the nomogram via internal and external validation. Results: Of 38 796 patients, 21 302 (54.91%) were women. The delayed recovery aggregate rate was 1.38% [95% CI, (1.27, 1.50%)]. In a generalized linear model, risk factors for delayed recovery were old age [RR, 1.04, 95% CI, (1.03,1.05), P 〈 0.001], neurosurgery [RR, 2.75, 95% CI, (1.60, 4.72), P 〈 0.001], using antibiotics during surgery [RR, 1.30, 95% CI, (1.02, 1.66), P =0.036], long anesthesia duration [RR, 1.0025, 95% CI, (1.0013, 1.0038), P 〈 0.001], ASA grade of III [RR, 1.98, 95% CI, (1.38, 2.83), P 〈 0.001], and postoperative analgesia [RR, 1.41, 95% CI, (1.10, 1.80), P =0.006]. In the nomogram, old age and neurosurgery had high scores in the model and contributed significantly to the increased probability of delayed recovery. The area under the curve value of the nomogram was 0.77. The discrimination and calibration of the nomogram estimated by internal and external validation were generally satisfactory. Conclusion: This study demonstrates that delayed recovery in PACU after surgery was associated with old age, neurosurgery, long anesthesia duration, an ASA grade of III, using antibiotics during surgery, and postoperative analgesia. These findings provide predictors of delayed recovery in PACU, especially neurosurgeries and old age.
    Type of Medium: Online Resource
    ISSN: 1743-9159
    URL: Article
    DOI: 10.1097/JS9.0000000000000364
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2201966-2
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  • 8
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    Effect of cuff inflation with lidocaine, saline, and air on tracheal tube cuff pressure during laparoscopic resection of colorectal neoplasms: a randomized clinical trial
    Springer Science and Business Media LLC ; 2024
    In:  BMC Anesthesiology Vol. 24, No. 1 ( 2024-07-01)
    Details
    In: BMC Anesthesiology, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2024-07-01)
    Abstract: Tracheal tube cuff pressure will increase after pneumoperitoneum when the cuff is inflated with air, high pressure can cause tracheal mucosal damage. This prospective trial aimed to assess if inflating with normal saline or lidocaine can prevent increase of tracheal tube cuff pressure and tracheal mucosal damage in laparoscopic surgeries with general anesthesia. Whether changes of tracheal tube cuff transverse diameter (CD) can predict changes of tracheal tube cuff pressure. Methods Ninety patients scheduled for laparoscopic resection of colorectal neoplasms under general anesthesia were randomly assigned to groups air (A), saline (S) or lidocaine (L). Endotracheal tube cuff was inflated with room-temperature air in group A ( n = 30), normal saline in group S ( n = 30), 2% lidocaine hydrochloride injection in group L ( n = 30). After intubation, tracheal tube cuff pressure was monitored by a calibrated pressure transducers, cuff pressure was adjusted to 25 cmH 2 O (T 0.5 ). Tracheal tube cuff pressure at 15 min after pneumoperitoneum (T 1 ) and 15 min after exsufflation (T 2 ) were accessed. CD were measured by ultrasound at T 0.5 and T 1 , the ability of ΔCD (T 1-0.5 ) to predict cuff pressure was accessed. Tracheal mucous injury at the end of surgery were also recorded. Results Tracheal tube cuff pressure had no significant difference among the three groups at T 1 and T 2 . ΔCD had prediction value (AUC: 0.92 [95% CI: 0.81–1.02]; sensitivity: 0.99; specificity: 0.82) for cuff pressure. Tracheal mucous injury at the end of surgery were 0 (0, 1.0) in group A, 0 (0, 1.0) in group S, 0 (0, 0) in group L ( p = 0.02, group L was lower than group A and S, p = 0.03 and p = 0.04). Conclusions Compared to inflation with air, normal saline and 2% lidocaine cannot ameliorate the increase of tracheal tube cuff pressure during the pneumoperitoneum period under general anesthesia, but lidocaine can decrease postoperative tracheal mucosa injury. ΔCD measured by ultrasound is a predictor for changes of tracheal tube cuff pressure. Trial registration Chinese Clinical Trial Registry, identifier: ChiCTR2100054089, Date: 08/12/2021.
    Type of Medium: Online Resource
    ISSN: 1471-2253
    URL: Article
    DOI: 10.1186/s12871-024-02606-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2091252-3
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