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  • 1
    Online-Ressource
    Online-Ressource
    A novel general and efficient technique for dissociating antigen in circulating immune complexes
    Wiley ; 2018
    In:  ELECTROPHORESIS Vol. 39, No. 2 ( 2018-01), p. 406-416
    Details
    In: ELECTROPHORESIS, Wiley, Vol. 39, No. 2 ( 2018-01), p. 406-416
    Kurzfassung: Circulating immune complexes (CICs) are produced during the immune response. It is more clinically important to establish a general and efficient CICs dissociation technique for the detection of antigens for CICs other than the detection of free antigens in the serum. Polyethylene glycol (PEG) two‐precipitation separation and glycine‐HCl as a buffer system were employed to develop a general and efficient buffer dissociation technique to separate CICs from serum and dissociate antigens from CICs. The measurement value of new PEG two‐precipitation separation technique was higher than traditional PEG precipitation separation technique. There were slight differences in the dissociation conditions of HCV Core‐IC, HIV P24‐IC, Ins‐IC and TG‐IC as compared to HBsAg‐IC. The detection of antigens in HBsAg‐IC, HCV Core‐IC, HIV P24‐IC, Ins‐IC and TG‐IC with this technique was superior to that with HCl Dissociation, Trypsin Digestion or Immune Complex Transfer technique. PEG two‐precipitation dissociation technique may reduce macromolecular protein and the adhesion of free antigens during the co‐precipitation, which increases the efficiency of separation and precipitation of CICs. This technique also avoids the damage of reagents to antigens, assuring the repeatability, reliability and validity. Thus, this technique is application in samples negative or positive for free antigens.
    Materialart: Online-Ressource
    ISSN: 0173-0835 , 1522-2683
    URL: Issue
    URL: Article
    DOI: 10.1002/elps.v39.2
    DOI: 10.1002/elps.201700246
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 1475486-1
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Small-sized red-emitting core/shell/shell nanoparticles through an efficient energy back transfer process
    Elsevier BV ; 2020
    In:  Applied Surface Science Vol. 514 ( 2020-06), p. 146074-
    Details
    In: Applied Surface Science, Elsevier BV, Vol. 514 ( 2020-06), p. 146074-
    Materialart: Online-Ressource
    ISSN: 0169-4332
    URL: Article
    DOI: 10.1016/j.apsusc.2020.146074
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2020
    ZDB Id: 2002520-8
    ZDB Id: 52886-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway
    MDPI AG ; 2019
    In:  Toxins Vol. 11, No. 9 ( 2019-09-17), p. 540-
    Details
    In: Toxins, MDPI AG, Vol. 11, No. 9 ( 2019-09-17), p. 540-
    Kurzfassung: The aim of this research was to evaluate the potential protective mechanism of astaxanthin (ASTA) against oxidative damage and inflammation caused by ochratoxin (OTA) in mouse lung. We divided mice into a control group (CG), an OTA group (PG), an astaxanthin group (AG), and an OTA+ASTA group (JG). Oxidative indices (malondialdehyde (MDA), total superoxide dismutase (T-SOD), and reduced glutathione (GSH)) and inflammatory markers (interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α)) were assayed in the lung, and the lung-weight-to-body-weight ratio was calculated. Apoptosis was detected in pathological sections by the TdT-mediated dUTP nick-end labeling (TUNEL) assay. Oxidative damage and inflammation were detected in the lung of mice after exposure to OTA. Besides, Nrf2- and NF-κB-pathway-associated proteins were detected by Western blot. In contrast with OTA, ASTA significantly raised the expression of Nrf2, HO-1, and MnSOD, while the expression of other proteins (Keap1, TLR4, and NF-κB) was significantly decreased. These results indicate that ASTA exerted protective effects against OTA-induced oxidative damage and inflammation in the lung by regulating the Nrf2 and NF-κB pathways.
    Materialart: Online-Ressource
    ISSN: 2072-6651
    URL: Article
    DOI: 10.3390/toxins11090540
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2019
    ZDB Id: 2518395-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-03-04), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-03-04), p. 1-11
    Kurzfassung: This study assessed the protective mechanism of astaxanthin (ASX) against ochratoxin A- (OTA-) induced cardiac injury in mice. Four groups of mice were established: control group (0.1 mL olive   oil + 0.1   mL NaHCO 2 ), OTA group (0.1 mL OTA 5 mg/kg body weight), ASX group (0.1 mL ASX 100 mg/kg body weight), and ASX + OTA group (0.1 mL ASX 100 mg/kg body weight, 2 h later, 0.1 mL OTA 5 mg/kg body weight). The test period lasted for 27 days (7 days of dosing, 2 days of rest). Electrocardiogram, body weight, heart weight, tissue pathology, oxidative markers (malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)), biochemical markers (creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and lactate dehydrogenase (LDH)), electron microscopy, TUNEL, and Western blot tests were used to examine the effects of OTA on myocardial injury and ASX detoxification. The results showed that OTA exposure significantly decreased both body weight and heart weight. OTA induced a decrease in heart rate in mice and decreased tissue concentrations of SOD, CAT, and GSH, while increasing serum concentrations of cardiac enzymes (CK, CK-MB, and LDH) and tissue MDA. ASX improved heart rate, cardiac enzymes, and antioxidant levels in mice. The results of tissue pathology and TUNEL assay showed that ASX protects against OTA-induced myocardial injury. In addition, Western blot results showed that the OTA group upregulated Keap1, Bax, Caspase3, and Caspase9, while it downregulated Nrf2, HO-1, and Bcl-2 protein expression. ASX played a protective role by changing the expression of Keap1, Nrf2, HO-1, Bax, Bcl-2, Caspase3, and Caspase9 proteins. These results indicate that the protective mechanism of ASX on the myocardium works through the Keap1-Nrf2 signaling pathway and mitochondria-mediated apoptosis pathway. This study provides a molecular rationale for the mechanism underlying OTA-induced myocardial injury and the protective effect of ASX on the myocardium.
    Materialart: Online-Ressource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/7639109
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2455981-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Recent advances of nanomaterial-based anti-angiogenic therapy in tumor vascular normalization and immunotherapy
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-11-29)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-11-29)
    Kurzfassung: Anti-angiogenesis therapy and immunotherapy are the first-line therapeutic strategies for various tumor treatments in the clinic, bringing significant advantages for tumor patients. Recent studies have shown that anti-angiogenic therapy can potentiate immunotherapy, with many clinical trials conducted based on the combination of anti-angiogenic agents and immune checkpoint inhibitors (ICIs). However, currently available clinical dosing strategies and tools are limited, emphasizing the need for more improvements. Although significant progress has been achieved, several big questions remained, such as how to achieve cell-specific targeting in the tumor microenvironment? How to improve drug delivery efficiency in tumors? Can nanotechnology be used to potentiate existing clinical drugs and achieve synergistic sensitization effects? Over the recent few years, nanomedicines have shown unique advantages in antitumor research, including cell-specific targeting, improved delivery potentiation, and photothermal effects. Given that the applications of nanomaterials in tumor immunotherapy have been widely reported, this review provides a comprehensive overview of research advances on nanomaterials in anti-angiogenesis therapy, mainly focusing on the immunosuppressive effects of abnormal tumor vessels in the tumor immune microenvironment, the targets and strategies of anti-angiogenesis nanomedicines, and the potential synergistic effects and molecular mechanisms of anti-angiogenic nanomedicines in combination with immunotherapy, ultimately providing new perspectives on the nanomedicine-based synergy between anti-angiogenic and immunotherapy.
    Materialart: Online-Ressource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.1039378
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2649216-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    DataSheet_1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Immunology Vol. 14 ( 2023-4-27)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-4-27)
    Kurzfassung: Obesity is often accompanied by lower 25(OH)D levels, whereas these two parameters exhibit opposite effects on bone health. It is uncertain what are the effects of lower 25(OH)D levels in obesity on bone health in elderly Chinese people. Methods A nationally representative cross-sectional analysis of China Community-based Cohort of Osteoporosis (CCCO) was performed from 2016 to 2021, which consisted of 22,081 participants. Demographic data, disease history, Body mass index (BMI), bone mineral density (BMD), the levels of the biomarkers of vitamin D status and those of bone metabolism markers were measured for all participants (N = 22,081). The genes (rs12785878, rs10741657, rs4588, rs7041, rs2282679 and rs6013897) related to 25(OH)D transportation and metabolism were performed in a selected subgroup (N = 6008). Results Obese subjects exhibited lower 25(OH)D levels (p & lt; 0.05) and higher BMD (p & lt; 0.001) compared with those of normal subjects following adjustment. The genotypes and allele frequency of rs12785878, rs10741657, rs6013897, rs2282679, rs4588 and rs7041 indicated no significant differences among three BMI groups following correction by the Bonferroni’s method (p & gt; 0.05). The levels of total 25(OH)D (ToVD) were significantly different among the GC1F, GC1S and GC2 haplotype groups (p & lt; 0.05). Correlation analysis indicated that ToVD levels were significantly correlated with parathyroid hormone levels, BMD, risk of osteoporosis (OP) and the concentration levels of other bone metabolism markers (p & lt; 0.05). Generalized varying coefficient models demonstrated that the increasing BMI, ToVD levels and their interactions were positively associated with BMD outcomes (p & lt; 0.001), whereas the reduced levels of ToVD and BMI increased the risk of OP, which was noted notably for the subjects with reduced ToVD levels (less than 20.69 ng/ml) combined with decreased BMI (less than 24.05 kg/m 2 ). Conclusion There was a non-linear interaction of BMI and 25(OH)D. And higher BMI accompanied by decreased 25(OH)D levels is associated with increased BMD and decreased incidence of OP, optimal ranges exist for BMI and 25(OH)D levels. The cutoff value of BMI at approximately 24.05 kg/m 2 combined with an approximate value of 25(OH)D at 20.69 ng/ml are beneficial for Chinese elderly subjects.
    Materialart: Online-Ressource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2023.1162175
    DOI: 10.3389/fimmu.2023.1162175.s001
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2023
    ZDB Id: 2606827-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    High‐Performance Aqueous Zinc–Ion Battery Based on Layered H 2 V 3 O 8 Nanowire Cathode
    Wiley ; 2017
    In:  Small Vol. 13, No. 47 ( 2017-12)
    Details
    In: Small, Wiley, Vol. 13, No. 47 ( 2017-12)
    Kurzfassung: Rechargeable aqueous zinc–ion batteries have offered an alternative for large‐scale energy storage owing to their low cost and material abundance. However, developing suitable cathode materials with excellent performance remains great challenges, resulting from the high polarization of zinc ion. In this work, an aqueous zinc–ion battery is designed and constructed based on H 2 V 3 O 8 nanowire cathode, Zn(CF 3 SO 3 ) 2 aqueous electrolyte, and zinc anode, which exhibits the capacity of 423.8 mA h g −1 at 0.1 A g −1 , and excellent cycling stability with a capacity retention of 94.3% over 1000 cycles. The remarkable electrochemical performance is attributed to the layered structure of H 2 V 3 O 8 with large interlayer spacing, which enables the intercalation/de‐intercalation of zinc ions with a slight change of the structure. The results demonstrate that exploration of the materials with large interlayer spacing is an effective strategy for improving electrochemical stability of electrodes for aqueous Zn ion batteries.
    Materialart: Online-Ressource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v13.47
    DOI: 10.1002/smll.201702551
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2168935-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-4-19), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-4-19), p. 1-15
    Kurzfassung: Background. Chronic hyperglycemia-induced inflammation is recognized as the most important pathophysiological process in diabetic kidney disease (DKD). As maresin 1 (MaR1) is an extensive anti-inflammatory lipid mediator, the present study investigated the protective role of MaR1 in the pathogenesis of DKD and its clinical relevance. Methods. Serum MaR1 concentrations were analyzed in 104 subjects with normal glucose tolerant, type 2 diabetes (T2DM), or DKD. Streptozotocin (STZ) together with high fat diet was used to induce male C57BL/6 J mice into diabetic mice which were treated with MaR1. Human renal tubule epithelial cells (HK-2 cells) were treated by high glucose for glucotoxicity cell model and transfected with LGR6 siRNA for knockdown with MaR1 added，and detected oxidative stress and inflammatory related factors. Results. Serum MaR1 concentrations were significant decreased in T2DM with or without kidney disease compared with normal participant and were lowest in patients with DKD. Serum MaR1 concentrations were negatively correlated with hemoglobin A1c (HbA1c), duration of diabetes, urinary albumin to creatinine ratio (UACR), neutrophil, and neutrophil-lymphocyte ratio and were positively correlated with high-density lipoprotein-cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR). In mouse model, MaR1 injection alleviated hyperglycemia, UACR and the pathological progression of DKD. Interestingly, the renal expression of LGR6 was down-regulated in DKD and high glucose treated HK-2 cells but up-regulated by MaR1 treatment. Mechanistically, MaR1 alleviated inflammation via LGR6-mediated cAMP-SOD2 antioxidant pathway in DKD mice and high glucose treated HK-2 cells. Conclusions. Our study demonstrates that decreased serum MaR1 levels were correlated with the development of DKD. MaR1 could alleviate DKD and glucotoxicity-induced inflammation via LGR6-mediated cAMP-SOD2 antioxidant pathway. Thus, our present findings identify MaR1 as a predictor and a potential therapeutic target for DKD.
    Materialart: Online-Ressource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/7177889
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2455981-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Constructing a small core–multishell nanostructure for Ho-based red upconversion emission
    Royal Society of Chemistry (RSC) ; 2021
    In:  Journal of Materials Chemistry C Vol. 9, No. 12 ( 2021), p. 4385-4392
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 9, No. 12 ( 2021), p. 4385-4392
    Materialart: Online-Ressource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/D1TC00115A
    Sprache: Englisch
    Verlag: Royal Society of Chemistry (RSC)
    Publikationsdatum: 2021
    ZDB Id: 2702245-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    A novel upconversion core–multishell nanoplatform for a highly efficient photoswitch
    Royal Society of Chemistry (RSC) ; 2020
    In:  Journal of Materials Chemistry C Vol. 8, No. 10 ( 2020), p. 3483-3490
    Details
    In: Journal of Materials Chemistry C, Royal Society of Chemistry (RSC), Vol. 8, No. 10 ( 2020), p. 3483-3490
    Materialart: Online-Ressource
    ISSN: 2050-7526 , 2050-7534
    URL: Article
    DOI: 10.1039/C9TC06840F
    Sprache: Englisch
    Verlag: Royal Society of Chemistry (RSC)
    Publikationsdatum: 2020
    ZDB Id: 2702245-6
    Standort Signatur Einschränkungen Verfügbarkeit
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