In:
BMC Cancer, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2013-12)
Abstract:
Whether the 7th edition of American Joint Committee on Cancer (AJCC) TNM staging system (AJCC-7) is a successful revision remains debatable. We aimed to compare the predictive capacity of the AJCC-7 for colorectal cancer with the 6th edition of the AJCC TNM staging system (AJCC-6). Methods The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) dataset consisting of 158,483 records was used in this study. We evaluated the predictive capacity of the two editions of the staging system using Harrell’s C index and Bayesian Information Criterion (BIC). Results There was a significant prognostic difference between patients at stage IIB and IIC (P 〈 0.001). Stage III patients with similar prognoses were adequately sub-grouped in the same stage according to AJCC-7. The Harrell’s C index revealed a value of 0.7692 for AJCC-7, which was significantly better than 0.7663 for AJCC-6 (P 〈 0.001). BIC analysis provided consistent results (P 〈 0.001). Conclusions This study demonstrates that AJCC-7 is superior to the AJCC-6 staging system in predictive capacity.
Type of Medium:
Online Resource
ISSN:
1471-2407
DOI:
10.1186/1471-2407-13-123
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2013
detail.hit.zdb_id:
2041352-X
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