In:
Angewandte Chemie, Wiley, Vol. 128, No. 28 ( 2016-07-04), p. 8173-8176
Abstract:
A stereoselective Koenigs–Knorr glycosylation reaction under the catalysis of urea is described. This method is characterized by urea‐mediated hydrogen‐bond activation and subsequent glycosylation with glycosyl chlorides or bromides. Excellent yields and high anomeric selectivity can be achieved in most cases. Moreover, the low α‐stereoselectivity of glycosylations observed when using perbenzylated glucosyl donors can be greatly improved by the addition of tri‐(2,4,6‐trimethoxyphenyl)phosphine (TTMPP).
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v128.28
DOI:
10.1002/ange.201600142
Language:
English
Publisher:
Wiley
Publication Date:
2016
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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