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  • 1
    Online Resource
    Online Resource
    Quantum interference between spin-orbit split partial waves in the F + HD → HF + D reaction
    American Association for the Advancement of Science (AAAS) ; 2021
    In:  Science Vol. 371, No. 6532 ( 2021-02-26), p. 936-940
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 371, No. 6532 ( 2021-02-26), p. 936-940
    Abstract: The effect of electron spin-orbit interactions on chemical reaction dynamics has been a topic of much research interest. Here we report a combined experimental and theoretical study on the effect of electron spin and orbital angular momentum in the F + HD → HF + D reaction. Using a high-resolution imaging technique, we observed a peculiar horseshoe-shaped pattern in the product rotational-state–resolved differential cross sections around the forward-scattering direction. The unusual dynamics pattern could only be explained properly by highly accurate quantum dynamics theory when full spin-orbit characteristics were considered. Theoretical analysis revealed that the horseshoe pattern was largely the result of quantum interference between spin-orbit split–partial-wave resonances with positive and negative parities, providing a distinctive example of how spin-orbit interaction can effectively influence reaction dynamics.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.abf4205
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2021
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Breakdown of the Born-Oppenheimer Approximation in the F+ o -D 2 → DF + D Reaction
    American Association for the Advancement of Science (AAAS) ; 2007
    In:  Science Vol. 317, No. 5841 ( 2007-08-24), p. 1061-1064
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 317, No. 5841 ( 2007-08-24), p. 1061-1064
    Abstract: The reaction of F with H 2 and its isotopomers is the paradigm for an exothermic triatomic abstraction reaction. In a crossed-beam scattering experiment, we determined relative integral and differential cross sections for reaction of the ground F( 2 P 3/2 ) and excited F*( 2 P 1/2 ) spin-orbit states with D 2 for collision energies of 0.25 to 1.2 kilocalorie/mole. At the lowest collision energy, F* is ∼1.6 times more reactive than F, although reaction of F* is forbidden within the Born-Oppenheimer (BO) approximation. As the collision energy increases, the BO-allowed reaction rapidly dominates. We found excellent agreement between multistate, quantum reactive scattering calculations and both the measured energy dependence of the F*/F reactivity ratio and the differential cross sections. This agreement confirms the fundamental understanding of the factors controlling electronic nonadiabaticity in abstraction reactions.
    Type of Medium: Online Resource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1144984
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: American Association for the Advancement of Science (AAAS)
    Publication Date: 2007
    detail.hit.zdb_id: 128410-1
    detail.hit.zdb_id: 2066996-3
    detail.hit.zdb_id: 2060783-0
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    A First-in-Human Trial of GLS4, a Novel Inhibitor of Hepatitis B Virus Capsid Assembly, following Single- and Multiple-Ascending-Oral-Dose Studies with or without Ritonavir in Healthy Adult Volunteers
    American Society for Microbiology ; 2019
    In:  Antimicrobial Agents and Chemotherapy Vol. 64, No. 1 ( 2019-12-20)
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 64, No. 1 ( 2019-12-20)
    Abstract: GLS4 is a novel inhibitor of the hepatitis B virus (HBV) capsid assembly with inhibitory activities against nucleot(s)ide-resistant HBV strains. This study investigated the pharmacokinetics, safety, and tolerability of GLS4 and the effects of food and ritonavir in healthy adults. GLS4 was administered in a single-ascending-dose study over 1 to 240 mg and multiple-ascending-dose study that ranged from 30 mg once daily to 180 mg three times daily. The drug interaction study included sequential design (day 1 for 120 mg GLS4 alone, day 5 for 100 mg ritonavir alone, followed by 9 days of both drugs) and a placebo control (9 days of both 240 mg GLS4 and 100 mg ritonavir). The results showed that the steady-state trough concentration of multiple dosing of GLS4 alone was significantly lower than the 90% effective concentration of 55.7 ng/ml, even with increasing dosing frequency and dosage. An initial dose of 100 mg ritonavir significantly boosted plasma concentration at 24 h of 120 mg GLS4 from 2.40 to 49.8 ng/ml (geometric mean ratio, 20.7; 90% confidence interval, 17.0 to 25.3), while a milder effect was observed on the area under the curve from 0 to 24 h, with a 7.42-fold increase, and on the maximum concentration, with a 4.82-fold increase. The pharmacokinetics change in GLS4 persisted after 9 days of chronic dosing, with a trough concentration of 182 ng/ml. Both single and multiple doses of GLS4 up to 240 mg with or without ritonavir were well tolerated. These results support the investigation of a novel HBV treatment regimen containing GLS4 with 100 mg ritonavir added solely to enhance GLS4 concentrations in plasma. (This study was registered at the China Platform for Registry and Publicity of Drug Clinical Trials [ http://www.chinadrugtrials.org.cn ] under numbers CTR20132137 and CTR20150230.)
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.01686-19
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2019
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    2D deblending using the multi-scale shaping scheme
    Elsevier BV ; 2018
    In:  Journal of Applied Geophysics Vol. 148 ( 2018-01), p. 44-54
    Details
    In: Journal of Applied Geophysics, Elsevier BV, Vol. 148 ( 2018-01), p. 44-54
    Type of Medium: Online Resource
    ISSN: 0926-9851
    URL: Article
    DOI: 10.1016/j.jappgeo.2017.10.014
    RVK:
    UA 4543
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 1496997-X
    SSG: 16,13
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  • 5
    Online Resource
    Online Resource
    Application of fatty acids as antiviral agents against tobacco mosaic virus
    Elsevier BV ; 2017
    In:  Pesticide Biochemistry and Physiology Vol. 139 ( 2017-06), p. 87-91
    Details
    In: Pesticide Biochemistry and Physiology, Elsevier BV, Vol. 139 ( 2017-06), p. 87-91
    Type of Medium: Online Resource
    ISSN: 0048-3575
    URL: Article
    DOI: 10.1016/j.pestbp.2017.05.005
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1471454-1
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Synthesis, and biological evaluation of pyrazole matrine derivatives as an insecticide against Spodoptera frugiperda
    Elsevier BV ; 2023
    In:  Pesticide Biochemistry and Physiology Vol. 194 ( 2023-08), p. 105489-
    Details
    In: Pesticide Biochemistry and Physiology, Elsevier BV, Vol. 194 ( 2023-08), p. 105489-
    Type of Medium: Online Resource
    ISSN: 0048-3575
    URL: Article
    DOI: 10.1016/j.pestbp.2023.105489
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1471454-1
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Type 1 5′-deiodinase activity is inhibited by oxidative stress and restored by alpha-lipoic acid in HepG2 cells
    Elsevier BV ; 2016
    In:  Biochemical and Biophysical Research Communications Vol. 472, No. 3 ( 2016-04), p. 496-501
    Details
    In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 472, No. 3 ( 2016-04), p. 496-501
    Type of Medium: Online Resource
    ISSN: 0006-291X
    URL: Article
    DOI: 10.1016/j.bbrc.2016.02.119
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 1461396-7
    SSG: 12
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    Online Resource
  • 8
    Online Resource
    Online Resource
    Besieged privacy in social networking services
    Inderscience Publishers ; 2016
    In:  International Journal of Electronic Security and Digital Forensics Vol. 8, No. 3 ( 2016), p. 224-
    Details
    In: International Journal of Electronic Security and Digital Forensics, Inderscience Publishers, Vol. 8, No. 3 ( 2016), p. 224-
    Type of Medium: Online Resource
    ISSN: 1751-911X , 1751-9128
    URL: Article
    DOI: 10.1504/IJESDF.2016.077447
    Language: English
    Publisher: Inderscience Publishers
    Publication Date: 2016
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  • 9
    Online Resource
    Online Resource
    Identification of the Phytoplasma Associated with Wheat Blue Dwarf Disease in China
    Scientific Societies ; 2010
    In:  Plant Disease Vol. 94, No. 8 ( 2010-08), p. 977-985
    Details
    In: Plant Disease, Scientific Societies, Vol. 94, No. 8 ( 2010-08), p. 977-985
    Abstract: Wheat blue dwarf disease (WBD) was first reported in China in the 1960s. It has caused severe losses on several occasions in winter wheat (Triticum aestivum) in northwestern China, and the nature of the pathogenic agent has been unknown. Here we have shown that WBD was caused by a 16SrI-C phytoplasma transmitted by Psammotettix striatus. This finding was based on molecular diagnostics, insect transmission trials, and host-range determination. Portions of the 16S rRNA and ribosomal protein (rp) genes, rpsS (rps19), rplV (rpl22), and rpsC (rps3), were amplified from DNA samples of WBD-infected wheat seedlings by polymerase chain reaction (PCR) utilizing phytoplasma specific primer pairs. The nucleotide sequences of these amplicons showed high identity to these genes from phytoplasma strains in the aster yellows group (16SrI). Pairwise nucleotide sequence identities of WBD 16S rDNA compared to representative genes of 16SrI group strains ranged from 98.9 to 99.9%, whereas compared to 17 other phytoplasma groups (16SrII to 16SrXVIII), sequence identity ranged from 88.6 to 96.0%. Similarly, the sequence identities of rps19, rpl22, and rps3 between WBD and 16SrI group strains varied from 96.6 to 99.7%, but only 60.3 to 65% between WBD and other phytoplasma groups. Phylogenetic analyses were carried out on sequences from 16S rRNA and ribosomal protein genes (rps19, rpl22, and rps3), respectively, and both results indicated that WBD phytoplasma was a member of the 16SrI group and most closely related to subgroup 16SrI-C. WBD-infected P. striatus were present in wheat fields with WBD, and phytoplasma infection was verified by PCR detection followed by DNA sequencing. Insect transmission trials confirmed that P. striatus transmitted the WBD phytoplasmal agent from infected wheat to healthy wheat seedlings and seven other different plant species in the greenhouse. A survey of various weed species near WBD-infected wheat fields found 10 plant species in seven families to be positive for the presence of WBD phytoplasma.
    Type of Medium: Online Resource
    ISSN: 0191-2917 , 1943-7692
    URL: Article
    DOI: 10.1094/PDIS-94-8-0977
    Language: English
    Publisher: Scientific Societies
    Publication Date: 2010
    detail.hit.zdb_id: 2042679-3
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  • 10
    Online Resource
    Online Resource
    Community Dynamics in Structure and Function of Honey Bee Gut Bacteria in Response to Winter Dietary Shift
    American Society for Microbiology ; 2022
    In:  mBio Vol. 13, No. 5 ( 2022-10-26)
    Details
    In: mBio, American Society for Microbiology, Vol. 13, No. 5 ( 2022-10-26)
    Abstract: Temperate honey bees ( Apis mellifera ) are challenged by low temperatures and abrupt dietary shifts associated with behavioral changes during winter. Case studies have revealed drastic turnover in the gut microbiota of winter bees, highlighted by the seasonal dominance of a non-core bacterium Bartonella . However, neither biological consequence nor underlying mechanism of this microbial turnover is clear. In particular, we ask whether such changes in gut profile are related to winter dietary shift and possibly beneficial to host and associated gut microbiome? Here, we integrated evidences from genomics, metagenomics, and metabolomics in three honey bee subspecies maintained at the same locality of northern China to profile both diversity and functional variations in gut bacteria across seasons. Our results showed that winter dominance of Bartonella was shared in all tested honey bee lineages. This seasonal change was likely a consequence of winter dietary shifts characterized by greatly reduced pollen consumption and accumulation of metabolic waste due to restricted excretion. Bartonella showed expanded genomic capacity in utilizing more diverse energy substrates, such as converting metabolic wastes lactate and ethanol into pyruvate, an energy source for self-utilization and possibly also for host and other symbionts. Furthermore, Bartonella was the only bacterium capable of both producing and secreting tryptophan and phenylalanine, whose metabolic products were detected in bee guts, even though all gut bacteria lacked relevant digestion enzymes. These results thus suggested a possible mechanism where the gut bacteria might benefit the host by supplementing them with essential amino acids lacking in a protein shortage diet. IMPORTANCE The abilities to survive winter and to adapt to major food changes are key traits that have enabled successful range expansion of the honey bees from the tropic to temperate climate. Our results highlighted a new possibility that gut bacteria may have played an important role in host survival of the severe winter condition. The non-core bacterium Bartonella is not only more adaptive to the winter diet but is also equipped with the capacity to provide the host with essential nutrients and important metabolic substrates. This overall host-bacterium profile is probably favored by natural selection, resulting in a consistent winter gut strategy across varied honey bee lineages. Conversely, when the hosts start to forage again, core bacteria maintained at low abundance during winter returned to their typical dominant status, thus completing the annual gut turnover. Our study suggests a new hypothesis where seasonal gut variations may improve the fitness of the honey bee, allowing them to explore more diverse climates.
    Type of Medium: Online Resource
    ISSN: 2150-7511
    URL: Article
    DOI: 10.1128/mbio.01131-22
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2557172-2
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