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  • 1
    Online Resource
    Online Resource
    Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
    Springer Science and Business Media LLC ; 2011
    In:  Nature Genetics Vol. 43, No. 7 ( 2011-7), p. 690-694
    Details
    In: Nature Genetics, Springer Science and Business Media LLC, Vol. 43, No. 7 ( 2011-7), p. 690-694
    Type of Medium: Online Resource
    ISSN: 1061-4036 , 1546-1718
    URL: Article
    DOI: 10.1038/ng.851
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 1494946-5
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Data_Sheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 8 ( 2022-1-3)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2022-1-3)
    Abstract: Backgrounds: Anticoagulation in sepsis-associated disseminated intravascular coagulation (DIC) remains uncertain. The aim of this study was to investigate whether unfractioned heparin (UFH) could improve clinical outcomes in patients with sepsis-induced coagulopathy (SIC). Methods: Septic patients with SIC were identified from the Medical Information Mart for Intensive Care (MIMIC)-III database. Cox-proportional hazards model, logistic regression model and linear regression were used to assess the associations between UFH administration and 28-day mortality, hospital mortality, occurrence of bleeding complications and length of stay, respectively. Propensity score matching (PSM) analysis was used to match the imbalance between patients in the UFH group and the control group. Patients were further stratified according to SIC score and Simplified Acute Physiology Score II (SAPS II). Results: A total of 1,820 septic patients with SIC were included in the data analysis. After PSM, 652 pairs of patients were matched between the patients in the UFH group and the control group. UFH was significantly associated with reduced 28-day mortality (HR, 0.323, 95% CI, 0.258–0.406; p & lt; 0.001) and hospital mortality (HR, 0.380, 95% CI, 0.307–0.472; p & lt; 0.001) without increasing the risks of intracranial hemorrhage (OR, 1.480, 95% CI, 0.955–2.294; p = 0.080) or gastrointestinal bleeding (OR, 1.094, 95% CI, 0.503–2.382; p = 0.820). For subgroup analysis, it didn't change the favorable results of UFH on mortality and UFH didn't increase the risk of hemorrhage in patients with severe disease. Conclusions: The analysis of MIMIC-III database indicated that anticoagulant therapy with UFH may be associated with a survival benefit in patients with SIC.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2021.773339
    DOI: 10.3389/fmed.2021.773339.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 3
    Online Resource
    Online Resource
    Usefulness of procalcitonin clearance to predict mortality in abdominal sepsis
    SAGE Publications ; 2020
    In:  European Journal of Inflammation Vol. 18 ( 2020-01), p. 205873922094263-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 18 ( 2020-01), p. 205873922094263-
    Abstract: To evaluate the plasma levels and clearance of procalcitonin (PCTc) as prognostic biomarkers for patients with abdominal sepsis. A retrospective study of 103 patients with abdominal sepsis was conducted in our intensive care unit (ICU) from 2016 to 2018. Procalcitonin (PCT) plasma levels were measured at the time of diagnosis of abdominal sepsis and daily over the next 5 days. PCTc was calculated from day 3 to day 5. The prognostic accuracy of PCTc was expressed as the area under the receiver operating characteristic curve (AUROC). The Kaplan–Meier method was used to compare the survival curves by log-rank test. Logistic regression analysis was used to predict the 28-day mortality. The primary outcome was 28-day mortality since admission to ICU. Serum PCT levels from day 1 to day 5 did not differ significantly between survivors and non-survivors, while PCTc on day 5 was statistically significantly higher in survivors than that in non-survivors (86.4% vs 38.7%, P  〈  0.001). The cutoff value for PCTc-day 5 was 70%, with AUROC of 0.726, sensitivity of 64.6%, and specificity of 78.3%. The 28-day mortality was significantly lower among those with PCTc-day 5 〉 70% compared with those with PCTc-day 5 〈 70% (9.1% vs 38.3%, log-rank test, P  〈  0.001), and odds ratio (OR) was 0.16 (95% confidence interval (CI): 0.05–0.48, P  〈  0.001). The ability to decrease PCT by at least 70% on day 5 was an independent predictor of 28-day mortality after admission to ICU with moderate accuracy.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739220942631
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2584683-8
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  • 4
    Online Resource
    Online Resource
    Biodegradation of the sulfonylurea herbicide chlorimuron-ethyl by the strain Pseudomonas sp. LW3
    Oxford University Press (OUP) ; 2009
    In:  FEMS Microbiology Letters Vol. 296, No. 2 ( 2009-07), p. 203-209
    Details
    In: FEMS Microbiology Letters, Oxford University Press (OUP), Vol. 296, No. 2 ( 2009-07), p. 203-209
    Type of Medium: Online Resource
    ISSN: 0378-1097 , 1574-6968
    URL: Issue
    URL: Article
    DOI: 10.1111/fml.2009.296.issue-2
    DOI: 10.1111/j.1574-6968.2009.01638.x
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2009
    detail.hit.zdb_id: 1501716-3
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Development and validation of a nomogram to predict the risk of renal replacement therapy among acute kidney injury patients in intensive care unit
    Springer Science and Business Media LLC ; 2023
    In:  Clinical and Experimental Nephrology
    Details
    In: Clinical and Experimental Nephrology, Springer Science and Business Media LLC
    Abstract: There are no universally accepted indications to initiate renal replacement therapy (RRT) among patients with acute kidney injury (AKI). This study aimed to develop a nomogram to predict the risk of RRT among AKI patients in intensive care unit (ICU). Methods In this retrospective cohort study, we extracted AKI patients from Medical Information Mart for Intensive Care III (MIMIC-III) database. Patients were randomly divided into a training cohort (70%) and a validation cohort (30%). Multivariable logistic regression based on Akaike information criterion was used to establish the nomogram. The discrimination and calibration of the nomogram were evaluated by Harrell’s concordance index ( C -index) and Hosmer–Lemeshow (HL) test. Decision curve analysis (DCA) was performed to evaluate clinical application. Results A total of 7413 critically ill patients with AKI were finally enrolled. 514 (6.9%) patients received RRT after ICU admission. 5194 (70%) patients were in the training cohort and 2219 (30%) patients were in the validation cohort. Nine variables, namely, age, hemoglobin, creatinine, blood urea nitrogen and lactate at AKI detection, comorbidity of congestive heart failure, AKI stage, and vasopressor use were included in the nomogram. The predictive model demonstrated satisfying discrimination and calibration with C -index of 0.938 (95% CI, 0.927–0.949; HL test, P  = 0.430) in training set and 0.935 (95% CI, 0.919–0.951; HL test, P  = 0.392) in validation set. DCA showed a positive net benefit of our nomogram. Conclusion The nomogram developed in this study was highly accurate for RRT prediction with potential application value.
    Type of Medium: Online Resource
    ISSN: 1342-1751 , 1437-7799
    URL: Article
    DOI: 10.1007/s10157-023-02383-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1499111-1
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  • 6
    Online Resource
    Online Resource
    The efficacy of extracorporeal membrane oxygenation in liver transplantation from non-heart-beating donors : A systemic review and meta-analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Medicine Vol. 98, No. 9 ( 2019-03), p. e14722-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 98, No. 9 ( 2019-03), p. e14722-
    Abstract: A systematic review and meta-analysis was made to see whether extracorporeal membrane oxygenation (ECMO) in liver transplantation could improve non-heart-beating donors (NHBDs) recipients’ outcomes compared with donors after brain death (DBDs) recipients. Methods: We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials for eligible studies. The study eligible criteria are cohort or case–control studies using ECMO in all NHBDs; studies involved a comparison group of DBDs; and studies evaluated 1-year graft and patient survival rate in NHBDs and DBDs groups. Results: Four studies with 704 patients fulfilled the inclusion criteria. The pooled odds ratio (OR) of 1-year patient survival rate in NHBDs recipients compared with DBDs recipients was 0.8 (95% confidence interval [CI], 0.41–1.55). The pooled OR of 1-year graft survival rate in NHBDs recipients compared with DBDs recipients was 0.46 (95% CI, 0.26–0.81). NHBDs recipients were at greater risks to the occurrence of primary nonfunction (PNF) (OR = 7.12, 95% CI, 1.84–27.52) and ischemic cholangiopathy (IC) (OR = 9.46, 95% CI, 2.76–32.4) than DBDs recipients. Conclusions: ECMO makes 1-year patient survival acceptable in NHBDs recipients. One-year graft survival rate was lower in NHBDs recipients than in DBDs recipients. Compared with DBDs recipients, the risks to develop PNF and IC were increased among NHBDs recipients.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000014722
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2049818-4
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  • 7
    Online Resource
    Online Resource
    Data_Sheet_1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Nutrition Vol. 10 ( 2023-3-23)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 10 ( 2023-3-23)
    Abstract: Malnutrition is associated with poor outcomes for geriatric patients in intensive care unit (ICU). It is important to identify patients at risk of malnutrition and provide individual nutrition support. The assessment of malnutrition risk is not easy for these patients due to their cognitive impairment. Geriatric nutrition risk index (GNRI) is a simple and objective scoring tool to evaluate the risk of malnutrition in elderly patients. In this study, we aimed to see whether GNRI score was appropriate to predict clinical outcomes among geriatric patients in the setting of ICU. Materials and methods Elderly patients with age ≥ 65 years were extracted from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Categories based on GNRI were classified as major risk (GNRI & lt;82), moderate risk (GNRI 82 to & lt;92), low risk (GNRI 92 to ≤98), and no risk (GNRI & gt;98). The primary outcome was all-cause hospital mortality. Multivariable Cox proportional hazards regression models and restricted cubic spline were used to investigate associations of GNRI with hospital mortality, respectively. A two-piecewise linear regression model was applied to examine the inflection point of GNRI on hospital mortality. To reduce selection bias, propensity score matching (PSM) was used in a 1:1 ratio. Results A total of 3,696 geriatric patients were finally included with median age 75 (69, 81) years. The prevalence of major risk was 28.6%. In the fully adjusted model, GNRI categories featured a negative trend with hospital mortality ( p for trend = 0.037). Restricted cubic spline analysis demonstrated an L-shaped relationship between GNRI and hospital mortality before and after matching. The inflection point was 78.7. At the left side of inflection point, GNRI levels were significantly negatively associated with hospital mortality (HR = 0.96, 95% CI: 0.94–0.98; p   & lt; 0.001) and featured no significant relations at the right side. Multiple linear regression also showed that GNRI was negatively associated with length of stay in hospital. Conclusion The major risk of malnutrition defined by GNRI was able to predict poor prognosis for geriatric patients admitted to ICU.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    URL: Article
    DOI: 10.3389/fnut.2023.1117054
    DOI: 10.3389/fnut.2023.1117054.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2776676-7
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  • 8
    Online Resource
    Online Resource
    Biotransformation of the Diphenyl Ether Herbicide Lactofen and Purification of a Lactofen Esterase from Brevundimonas sp. LY-2
    American Chemical Society (ACS) ; 2010
    In:  Journal of Agricultural and Food Chemistry Vol. 58, No. 17 ( 2010-09-08), p. 9711-9715
    Details
    In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 58, No. 17 ( 2010-09-08), p. 9711-9715
    Type of Medium: Online Resource
    ISSN: 0021-8561 , 1520-5118
    URL: Article
    DOI: 10.1021/jf101974y
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2010
    detail.hit.zdb_id: 1483109-0
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  • 9
    Online Resource
    Online Resource
    METFORMIN MITIGATES SEPSIS-ASSOCIATED PULMONARY FIBROSIS BY PROMOTING AMPK ACTIVATION AND INHIBITING HIF-1α–INDUCED AEROBIC GLYCOLYSIS
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Shock Vol. 61, No. 2 ( 2024-2), p. 283-293
    Details
    In: Shock, Ovid Technologies (Wolters Kluwer Health), Vol. 61, No. 2 ( 2024-2), p. 283-293
    Abstract: Recent research has revealed that aerobic glycolysis has a strong correlation with sepsis-associated pulmonary fibrosis (PF). However, at present, the mechanism and pathogenesis remain unclear. We aimed to test the hypothesis that the adenosine monophosphate-activated protein kinase (AMPK) activation and suppression of hypoxia-inducible factor 1α (HIF-1α)–induced aerobic glycolysis play a central role in septic pulmonary fibrogenesis. Cellular experiments demonstrated that lipopolysaccharide increased fibroblast activation through AMPK inactivation, HIF-1α induction, alongside an augmentation of aerobic glycolysis. By contrast, the effects were reversed by AMPK activation or HIF-1α inhibition. In addition, pretreatment with metformin, which is an AMPK activator, suppresses HIF-1α expression and alleviates PF associated with sepsis, which is caused by aerobic glycolysis, in mice. Hypoxia-inducible factor 1α knockdown demonstrated similar protective effects in vivo . Our research implies that targeting AMPK activation and HIF-1α–induced aerobic glycolysis with metformin might be a practical and useful therapeutic alternative for sepsis-associated PF.
    Type of Medium: Online Resource
    ISSN: 1073-2322
    URL: Article
    DOI: 10.1097/SHK.0000000000002275
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2011863-6
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  • 10
    Online Resource
    Online Resource
    Microbial Degradation of Fomesafen by a Newly Isolated Strain Pseudomonas zeshuii BY-1 and the Biochemical Degradation Pathway
    American Chemical Society (ACS) ; 2012
    In:  Journal of Agricultural and Food Chemistry Vol. 60, No. 29 ( 2012-07-25), p. 7104-7110
    Details
    In: Journal of Agricultural and Food Chemistry, American Chemical Society (ACS), Vol. 60, No. 29 ( 2012-07-25), p. 7104-7110
    Type of Medium: Online Resource
    ISSN: 0021-8561 , 1520-5118
    URL: Article
    DOI: 10.1021/jf3011307
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2012
    detail.hit.zdb_id: 1483109-0
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