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  • 1
    Online Resource
    Online Resource
    What is the meaning of a nonresolved viral nucleic acid test–reactive minipool?
    Wiley ; 2015
    In:  Transfusion Vol. 55, No. 2 ( 2015-02), p. 395-404
    Details
    In: Transfusion, Wiley, Vol. 55, No. 2 ( 2015-02), p. 395-404
    Abstract: This study aimed at analyzing the prevalence of hepatitis B virus ( HBV ) DNA among hepatitis  B surface antigen ( HB s A g)–negative donations by cobas T aq S creen MPX test ( R oche M olecular S ystems) and discussing the meaning of a reactive minipool ( MP ) that does not resolve to an individual donation ( ID )–reactive result. Study Design and Methods Nucleic acid amplification testing ( NAT ) was performed in 12 C hinese blood centers on 826,044 serologic negative donations in MP s of six. MP ‐reactive pools that were resolved to ID ‐reactive donations were confirmed by R oche T aq M an viral load assays. Antibody to hepatitis  B surface antigen and antibody to hepatitis  B core antigen (anti‐ HB c) results were also analyzed. Cycle threshold ( C t) values of reactive MP s were analyzed in relation to the probability of pool resolution. Results A total of 1267 of 137,674 pools were reactive, of which 839 donations were reactive by ID ‐ NAT . The MP 6 HBV NAT –yield rate lay between 1 in 1600 and 1 in 1000. At MP C t values equal or below 37, the probability of pool resolution was approximately 80%. The prevalence of anti‐ HB c in ID ‐reactive donations was 81%. The proportion of reactive pools that could not be resolved was 36%. The prevalence of anti‐ HB c in donations implicated in nonresolved MP s was significantly higher than those in nonreactive MP s (48% vs. 37%, p = 0.016). Conclusion The anti‐ HB c data suggest that approximately 10% of nonresolved MP s contain HBV DNA from a low‐viral‐load occult carrier. We consider ID ‐ NAT resolution testing in duplicate to minimize HBV transmission risk associated with transfusing nonreactive donations implicated in reactive MP s.
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    URL: Article
    DOI: 10.1111/trf.v55.2
    DOI: 10.1111/trf.12818
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2018415-3
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  • 2
    Online Resource
    Online Resource
    Molecular phylogeny of Chinese Stephania (Menispermaceae) and reassessment of the subgeneric and sectional classifications
    CSIRO Publishing ; 2015
    In:  Australian Systematic Botany Vol. 28, No. 4 ( 2015), p. 246-
    Details
    In: Australian Systematic Botany, CSIRO Publishing, Vol. 28, No. 4 ( 2015), p. 246-
    Abstract: Many species of Stephania Lour. are used traditionally in South-east Asia as medicinal plants. Understanding and predicting their therapeutic properties could be improved, provided that the evolutionary relationships among lineages are clarified. We present the first molecular phylogeny of the genus Stephania, focusing on the species occurring in China on the basis of nuclear (internal transcribed spacer, ITS) and chloroplast (trnL–F) markers sequenced from 29 species of Stephania. Our results showed that S. subgenus Stephania and S. subgenus Tuberiphania are not monophyletic, owing to the phylogenetic placement of a single species (S. mashanica). The relationships with the third subgenus, S. subgenus Botryodiscia, are not resolved. None of the sections in our analyses is monophyletic. Our study calls for further phylogenetic investigations including more accessions from the whole distribution area of the genus. A taxonomic revision of the genus Stephania, which would reassess the appropriateness of the macromorphological characters used so far to distinguish among subgenera (e.g. flower merism, size and aspect of the rootstock and main root), and sections (e.g. inflorescence morphology, sessiliflorous or not), is much needed.
    Type of Medium: Online Resource
    ISSN: 1030-1887
    URL: Article
    DOI: 10.1071/SB14023
    Language: English
    Publisher: CSIRO Publishing
    Publication Date: 2015
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Patient-Reported Outcome-Based Symptom Management Versus Usual Care After Lung Cancer Surgery: A Multicenter Randomized Controlled Trial
    American Society of Clinical Oncology (ASCO) ; 2022
    In:  Journal of Clinical Oncology Vol. 40, No. 9 ( 2022-03-20), p. 988-996
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, No. 9 ( 2022-03-20), p. 988-996
    Abstract: We aimed to evaluate the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in the early period after lung cancer surgery. METHODS Before surgery, patients with clinically diagnosed lung cancer were randomly assigned 1:1 to receive postoperative PRO-based symptom management or usual care. All patients reported symptoms on MD Anderson Symptom Inventory-Lung Cancer presurgery, daily postsurgery, and twice a week after discharge for up to 4 weeks via an electronic PRO system. In the intervention group, treating surgeons responded to overthreshold electronic alerts driven by any of the five target symptom scores (score ≥ 4 on a 0-10 scale for pain, fatigue, disturbed sleep, shortness of breath, and coughing). The control group patients received usual care and no alerts were generated. The primary outcome was the number of symptom threshold events (any target symptom with a score of ≥ 4) at discharge. Per-protocol analyses were conducted. RESULTS Of the 166 participants, 83 were randomly allocated to each group. At discharge, the intervention group reported fewer symptom threshold events than the control group (median [interquartile range], 0 [0-2] v 2 [0-3]; P = .007). At 4 weeks postdischarge, this difference was maintained between the intervention and control groups (median [interquartile range] , 0 [0-0] v 0 [0-1] ; P = .018). The intervention group had a lower complication rate than the control group (21.5% v 40.6%; P = .019). Surgeons spent a median of 3 minutes managing an alert. CONCLUSION PRO-based symptom management after lung cancer surgery showed lower symptom burden and fewer complications than usual care for up to 4 weeks postdischarge.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.21.01344
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2022
    detail.hit.zdb_id: 2005181-5
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  • 4
    Online Resource
    Online Resource
    Changes in Mobile Health Apps Usage Before and After the COVID-19 Outbreak in China: Semilongitudinal Survey
    JMIR Publications Inc. ; 2023
    In:  JMIR Public Health and Surveillance Vol. 9 ( 2023-2-22), p. e40552-
    Details
    In: JMIR Public Health and Surveillance, JMIR Publications Inc., Vol. 9 ( 2023-2-22), p. e40552-
    Abstract: Mobile health (mHealth) apps are rapidly emerging technologies in China due to strictly controlled medical needs during the COVID-19 pandemic while continuing essential services for chronic diseases. However, there have been no large-scale, systematic efforts to evaluate relevant apps. Objective We aim to provide a landscape of mHealth apps in China by describing and comparing digital health concerns before and after the COVID-19 outbreak, including mHealth app data flow and user experience, and analyze the impact of COVID-19 on mHealth apps. Methods We conducted a semilongitudinal survey of 1593 mHealth apps to study the app data flow and clarify usage changes and influencing factors. We selected mHealth apps in app markets, web pages from the Baidu search engine, the 2018 top 100 hospitals with internet hospitals, and online shopping sites with apps that connect to smart devices. For user experience, we recruited residents from a community in southeastern China from October 2019 to November 2019 (before the outbreak) and from June 2020 to August 2020 (after the outbreak) comparing the attention of the population to apps. We also examined associations between app characteristics, functions, and outcomes at specific quantiles of distribution in download changes using quantile regression models. Results Rehabilitation medical support was the top-ranked functionality, with a median 1.44 million downloads per app prepandemic and a median 2.74 million downloads per app postpandemic. Among the top 10 functions postpandemic, 4 were related to maternal and child health: pregnancy preparation (ranked second; fold change 4.13), women's health (ranked fifth; fold change 5.16), pregnancy (ranked sixth; fold change 5.78), and parenting (ranked tenth; fold change 4.03). Quantile regression models showed that rehabilitation (P75, P90), pregnancy preparation (P90), bodybuilding (P50, P90), and vaccination (P75) were positively associated with an increase in downloads after the outbreak. In the user experience survey, the attention given to health information (prepandemic: 249/375, 66.4%; postpandemic: 146/178, 82.0%; P=.006) steadily increased after the outbreak. Conclusions mHealth apps are an effective health care approach gaining in popularity among the Chinese population following the COVID-19 outbreak. This research provides direction for subsequent mHealth app development and promotion in the postepidemic era, supporting medical model reformation in China as a reference, which may provide new avenues for designing and evaluating indirect public health interventions such as health education and health promotion.
    Type of Medium: Online Resource
    ISSN: 2369-2960
    URL: Article
    DOI: 10.2196/40552
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2023
    detail.hit.zdb_id: 2874192-4
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  • 5
    Online Resource
    Online Resource
    Using rootstock to increase watermelon fruit yield and quality at low potassium supply: A comprehensive analysis from agronomic, physiological and transcriptional perspective
    Elsevier BV ; 2018
    In:  Scientia Horticulturae Vol. 241 ( 2018-11), p. 144-151
    Details
    In: Scientia Horticulturae, Elsevier BV, Vol. 241 ( 2018-11), p. 144-151
    Type of Medium: Online Resource
    ISSN: 0304-4238
    URL: Article
    DOI: 10.1016/j.scienta.2018.06.091
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2016351-4
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Identification and Characterization of Two Novel Noda-like Viruses from Rice Plants Showing the Dwarfing Symptom
    MDPI AG ; 2022
    In:  Viruses Vol. 14, No. 6 ( 2022-05-27), p. 1159-
    Details
    In: Viruses, MDPI AG, Vol. 14, No. 6 ( 2022-05-27), p. 1159-
    Abstract: Nodaviruses are small bipartite RNA viruses and are considered animal viruses. Here, we identified two novel noda-like viruses (referred to as rice-associated noda-like virus 1 (RNLV1) and rice-associated noda-like virus 2 (RNLV2)) in field-collected rice plants showing a dwarfing phenotype through RNA-seq. RNLV1 genome consists of 3335 nt RNA1 and 1769 nt RNA2, and RNLV2 genome consists of 3279 nt RNA1 and 1525 nt RNA2. Three conserved ORFs were identified in each genome of the two novel viruses, encoding an RNA-dependent RNA polymerase, an RNA silencing suppressor, and a capsid protein, respectively. The results of sequence alignment, protein domain prediction, and evolutionary analysis indicate that these two novel viruses are clearly different from the known nodaviruses, especially the CPs. We have also determined that the B2 protein encoded by the two new noda-like viruses can suppress RNA silencing in plants. Two reverse genetic systems were constructed and used to show that RNLV1 RNA1 can replicate in plant cells and RNLV1 can replicate in insect Sf9 cells. We have also found two unusual peptidase family A21 domains in the RNLV1 CP, and RNLV1 CP can self-cleave in acidic environments. These findings provide new knowledge of novel nodaviruses.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    URL: Article
    DOI: 10.3390/v14061159
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2516098-9
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  • 7
    Online Resource
    Online Resource
    End-to-End Super-Resolution for Remote-Sensing Images Using an Improved Multi-Scale Residual Network
    MDPI AG ; 2021
    In:  Remote Sensing Vol. 13, No. 4 ( 2021-02-12), p. 666-
    Details
    In: Remote Sensing, MDPI AG, Vol. 13, No. 4 ( 2021-02-12), p. 666-
    Abstract: Remote-sensing images constitute an important means of obtaining geographic information. Image super-resolution reconstruction techniques are effective methods of improving the spatial resolution of remote-sensing images. Super-resolution reconstruction networks mainly improve the model performance by increasing the network depth. However, blindly increasing the network depth can easily lead to gradient disappearance or gradient explosion, increasing the difficulty of training. This report proposes a new pyramidal multi-scale residual network (PMSRN) that uses hierarchical residual-like connections and dilation convolution to form a multi-scale dilation residual block (MSDRB). The MSDRB enhances the ability to detect context information and fuses hierarchical features through the hierarchical feature fusion structure. Finally, a complementary block of global and local features is added to the reconstruction structure to alleviate the problem that useful original information is ignored. The experimental results showed that, compared with a basic multi-scale residual network, the PMSRN increased the peak signal-to-noise ratio by up to 0.44 dB and the structural similarity to 0.9776.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    URL: Article
    DOI: 10.3390/rs13040666
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2513863-7
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  • 8
    Online Resource
    Online Resource
    CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis
    Springer Science and Business Media LLC ; 2023
    In:  Biochemical Genetics Vol. 61, No. 4 ( 2023-08), p. 1625-1644
    Details
    In: Biochemical Genetics, Springer Science and Business Media LLC, Vol. 61, No. 4 ( 2023-08), p. 1625-1644
    Abstract: CircRNAs are implicated in the development of several cancers. Nevertheless, the involvement of circ_0000118 in the development of cervical cancer (CC) remains unclear. Circ_0000118 levels in tumor tissues and cells were examined by qRT-PCR. The function of circ_0000118 in regulating the malignancy of CC cells was investigated using functional assays, including CCK-8, colony formation, transwell, and tube formation experiments. The functional interaction between circ_0000118 and microRNAs were validated by dual-luciferase activity assay and RNA precipitation experiments. In vivo mouse model was employed to assess the effect of circ_0000118 in the tumorigenesis of CC cells. Circ_0000118 was overexpressed in CC cells and tissues. Loss-of-function experiments demonstrated that circ_0000118 knockdown impaired the proliferation and tumor sphere formation, as well as the angiogenic potential of CC cells. RNA interaction experiments confirmed that circ_0000118 sponged miR-211-5p and miR-377-3p. AKT2 was found to be a target gene negatively modulated by miR-211-5p and miR-377-3p. AKT2 overexpression rescued the inhibition of circ_0000118 downregulation on CC cells. Our study suggested that circ_0000118 functions as an oncogenic factor in progression of CC by maintaining AKT2 level through targeting miR-211-5p and miR-377-3p as a ceRNA (competitive endogenous RNA), which provides novel therapeutic target in the management of CC.
    Type of Medium: Online Resource
    ISSN: 0006-2928 , 1573-4927
    URL: Article
    DOI: 10.1007/s10528-023-10332-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1496197-0
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    Fiscal spending and air pollution in Chinese cities: Identifying composition and technique effects
    Elsevier BV ; 2018
    In:  China Economic Review Vol. 47 ( 2018-02), p. 156-169
    Details
    In: China Economic Review, Elsevier BV, Vol. 47 ( 2018-02), p. 156-169
    Type of Medium: Online Resource
    ISSN: 1043-951X
    URL: Article
    DOI: 10.1016/j.chieco.2017.09.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2019641-6
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  • 10
    Online Resource
    Online Resource
    Quantification of plasmodesmata frequency under three-dimensional view using focused ion beam-scanning electron microscopy and image analysis
    Elsevier BV ; 2023
    In:  Micron Vol. 166 ( 2023-03), p. 103413-
    Details
    In: Micron, Elsevier BV, Vol. 166 ( 2023-03), p. 103413-
    Type of Medium: Online Resource
    ISSN: 0968-4328
    URL: Article
    DOI: 10.1016/j.micron.2023.103413
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1492133-9
    SSG: 11
    SSG: 12
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