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  • 1
    Online Resource
    Online Resource
    GW25-e1584 COL4A1 gene polymorphism is related to arterial pulse wave velocity in healthy Han Chinese subjects
    Elsevier BV ; 2014
    In:  Journal of the American College of Cardiology Vol. 64, No. 16 ( 2014-10), p. C18-
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 64, No. 16 ( 2014-10), p. C18-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/j.jacc.2014.06.089
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1468327-1
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  • 2
    Online Resource
    Online Resource
    Neuropsychiatric symptoms of patients with systemic lupus erythematosus caused by intracisternal deposited lupus IgG through meningitis
    The American Association of Immunologists ; 2017
    In:  The Journal of Immunology Vol. 198, No. 1_Supplement ( 2017-05-01), p. 55.3-55.3
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 198, No. 1_Supplement ( 2017-05-01), p. 55.3-55.3
    Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by high levels of autoantibodies and multi-organ tissue damage. Although neuropsychiatric symptoms are frequent in patients with SLE, its pathogenesis remains unclear. In this study, we investigated pathogenesis of neuropsychiatric symptoms in SLE patients. We analyzed the medical records of 1131 patients with SLE and conducted animal experiments. We found that fifty-nine patients showed NPSLE clinical manifestation including headaches, seizure disorder, cognitive dysfunction, cerebrovascular disease, etc. Lupus-prone mice spontaneously develop meningitis and apoptosis of neurons. IgG is a major contributor in meningitis. This meningitis depends on the dose of IgG, but is not associated with the kind of autoantibody and disease activity. Monocyte/macrophage and TNF play important role in the development of this meningitis. Lupus IgG induces the apoptosis of neurons directly. The deposited IgG in brain tissue exerts an important role in the pathogenesis of NPSLE. This finding will promote the development of an effective therapeutic strategy for NPSLE patients.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.198.Supp.55.3
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2017
    detail.hit.zdb_id: 1475085-5
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  • 3
    Online Resource
    Online Resource
    Value of the triglyceride glucose index combined with body mass index in identifying non-alcoholic fatty liver disease in patients with type 2 diabetes
    Springer Science and Business Media LLC ; 2022
    In:  BMC Endocrine Disorders Vol. 22, No. 1 ( 2022-12)
    Details
    In: BMC Endocrine Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12)
    Abstract: The triglyceride glucose index combined with body mass index is a new index that reflects the degree of insulin resistance. In this cross-sectional study, we aimed to explore the predictive value of the triglyceride glucose-body mass index (TyG-BMI) in relation to the occurrence of non-alcoholic fatty liver disease (NAFLD) in the Chinese population with type 2 diabetes (T2D). Methods We selected 826 patients with T2D who were hospitalized at the Department of Endocrinology and Metabolism of Karamay People’s Hospital from September 2016 to October 2018 for this research. The height, weight, fasting blood glucose, serum insulin, and lipid profiles of the subjects were collected. The liver ultrasound showed any degree of echogenic enhancement of liver tissue and the liver appeared brighter than the renal cortex on ultrasound were considered to be NAFLD. The logistic regression analysis was performed to estimate associations between the triglyceride glucose index (TyG), TyG-BMI index, insulin resistance index (HOMA-IR) and the ratio of the triglycerides to high-density lipoprotein-cholesterol with a diagnosis of NAFLD. The receiver operating characteristic curve method was used to analyze its predictive value for NAFLD. Results Results of the logistic regression analysis showed that the odds ratios of NAFLD were 6.535 (3.70–11.53) and 4.868 (2.576–9.200) for the TyG-BMI before and after correction,respectively( P   〈  0.001). The area under the curve (AUC) for TyG-BMI was 0.727 (0.691–0.764), which was the highest among all the other parameters studied. Conclusion Compared with the TyG index, the TG/HDL-C and HOMA-IR, the TyG-BMI was a more effective predictor of NAFLD in T2D.
    Type of Medium: Online Resource
    ISSN: 1472-6823
    URL: Article
    DOI: 10.1186/s12902-022-00993-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2091323-0
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  • 4
    Online Resource
    Online Resource
    Association between the lean nonalcoholic fatty liver disease and risk of incident type 2 diabetes in a healthy population of Northwest China: a retrospective cohort study with a 2-year follow-up period
    Frontiers Media SA ; 2023
    In:  Frontiers in Endocrinology Vol. 14 ( 2023-6-26)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 14 ( 2023-6-26)
    Abstract: We aimed to explore the metabolic features of lean nonalcoholic fatty liver disease (Lean-NAFLD) and its association with the risk of incident type 2 diabetes in young and middle-aged people. Methods We conducted a retrospective cohort study of 3001 participants who were enrolled in a health check-up program from January 2018 to December 2020 in the Health Management Center of Karamay People’s Hospital. The age, sex, height, weight, body mass index (BMI), blood pressure, waist circumference (WC), fasting plasma glucose (FPG), lipid profiles, serum uric acid and alanine aminotransferase (ALT) of the subjects were collected. The cutoff point of BMI for lean nonalcoholic fatty liver disease is & lt;25 kg/m 2 . A COX proportional hazard regression model was used to analyze the risk ratio of lean nonalcoholic fatty liver disease to type 2 diabetes mellitus. Results Lean NAFLD participants had many metabolic abnormalities, such as overweight and obesity with nonalcoholic fatty liver disease. Compared with lean participants without nonalcoholic fatty liver disease, the fully adjusted hazard ratio (HR) for lean participants with nonalcoholic fatty liver disease was 3.83 (95% CI 2.02-7.24, p & lt;0.01). In the normal waist circumference group (man & lt;90cm, woman & lt;80 cm), compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 1.93 (95% CI 0.70-5.35, p & gt;0.05) and 4.20 (95% CI 1.44-12.22, p & lt;0.05), respectively. For excess waist circumference (man≥90 cm, woman ≥80 cm) compared with lean participants without NAFLD, the adjusted hazard ratios (HRs) of incident type 2 diabetes for lean participants with NAFLD and overweight or obese participants with NAFLD were 3.88 (95% CI 1.56-9.66, p & lt;0.05) and 3.30 (95% CI 1.52-7.14, p & lt;0.05), respectively. Conclusion Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    DOI: 10.3389/fendo.2023.1173757
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2592084-4
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