In:
Dementia and Geriatric Cognitive Disorders Extra, S. Karger AG, Vol. 5, No. 1 ( 2015-3-13), p. 107-115
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt of 30 and 70°). Cardiac output, end-diastolic volume, total peripheral resistance, heart rate variability (HRV), systolic blood pressure variability (SBPV), and baroreceptor sensitivity were calculated. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 At 70° tilt, the HRV indices differed significantly, with higher high-frequency (HF) variability as well as lower low-frequency (LF) variability and LF/HF ratios in the patients. The patients had significantly lower SBPV in the LF range at 30° tilt. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The results indicate a poorer sympathetic response to orthostatic stress in MCI and mild AD.
Type of Medium:
Online Resource
ISSN:
1664-5464
Language:
English
Publisher:
S. Karger AG
Publication Date:
2015
detail.hit.zdb_id:
2621464-7
Permalink