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  • 1
    Online Resource
    Online Resource
    Noninvasive 3D-CT simulation versus glue injection to localize small pulmonary nodules prior to anatomical segmentecomy: A randomized controlled trial
    Oxford University Press (OUP) ; 2023
    In:  Interdisciplinary CardioVascular and Thoracic Surgery
    Details
    In: Interdisciplinary CardioVascular and Thoracic Surgery, Oxford University Press (OUP)
    Abstract: This study aimed to investigate whether adding glue-injection to three-dimensional computed tomography bronchography and angiography (3D-CTBA) has extra benefits to facilitate anatomical segmentectomy for pulmonary nodules. METHODS We conducted a randomized controlled trial. The patients undergoing thoracoscopic segmentectomy assisted with 3D-CTBA simulation were enrolled. Then they were divided into the 3D-CTBA group and the glue-labelling group who received additional CT-guided percutaneous glue (2-octyl cyanoacrylate) injection to label the nodules. The primary outcome was the resection rate of the nodules, and the secondary measures included the operation time, complications and thorax drainage. RESULTS A total of 173 patients were randomized into the 3D-CTBA group (89 patients) and glue-labelling group (84 patients) between January 2018 and March 2019. Before the segmentecomy, the patients using glue-labelling recorded 5 (6.0%) cases of pneumothorax, 2 (2.4%) cases of haemothorax, and 1 (1.2%) case of severe chest pain. All the surgical procedure was performed fluently and safely. The resection rate of the nodules was 100% in both groups. Furthermore, these patients demonstrated similar operation time [(141.5 ± 41.9) min vs (142.1 ± 38.9) min], estimated blood loss [(111.3 ± 74.0) mL vs (106.0 ± 63.8) mL] , duration of chest tube duration [(5.1 ± 3.0) days vs (5.0 ± 3.5) days], and total drainage volume [(872.3 ± 643.1) mL vs (826.7 ± 806.0) mL] , with a p value & gt;0.05 respectively. In addition, 6 (7.1%) patients in the glue-labelling group and 6 (6.7%) patients in the 3D-CTBA group reported air leakage ( & gt; 5 days) and chylothorax. CONCLUSIONS Noninvasive 3D-CTBA alone is probably sufficient to facilitate anatomical segmentectomy. The additional invasive glue-labelling could be avoided in selected patients who undergo intentional segmentectomy. Clinical trial registration The trial was registered under Chinese Clinical Trial Registry (ChiCTR). Identifier: ChiCTR1800018293. https://www.chictr.org.cn/showproj.html?proj=29345
    Type of Medium: Online Resource
    ISSN: 2753-670X
    URL: Article
    DOI: 10.1093/icvts/ivad156
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 3167862-2
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  • 2
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    Table_3.XLSX
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 12 ( 2021-7-5)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-7-5)
    Abstract: This study aimed to establish a prognostic risk model for lung adenocarcinoma (LUAD). We firstly divided 535 LUAD samples in TCGA-LUAD into high-, medium-, and low-immune infiltration groups by consensus clustering analysis according to immunological competence assessment by single-sample gene set enrichment analysis (ssGSEA). Profile of long non-coding RNAs (lncRNAs) in normal samples and LUAD samples in TCGA was used for a differential expression analysis in the high- and low-immune infiltration groups. A total of 1,570 immune-related differential lncRNAs in LUAD were obtained by intersecting the above results. Afterward, univariate COX regression analysis and multivariate stepwise COX regression analysis were conducted to screen prognosis-related lncRNAs, and an eight-immune-related-lncRNA prognostic signature was finally acquired (AL365181.2, AC012213.4, DRAIC, MRGPRG-AS1, AP002478.1, AC092168.2, FAM30A, and LINC02412). Kaplan–Meier analysis and ROC analysis indicated that the eight-lncRNA-based model was accurate to predict the prognosis of LUAD patients. Simultaneously, univariate COX regression analysis and multivariate COX regression analysis were undertaken on clinical features and risk scores. It was illustrated that the risk score was a prognostic factor independent from clinical features. Moreover, immune data of LUAD in the TIMER database were analyzed. The eight-immune-related-lncRNA prognostic signature was related to the infiltration of B cells, CD4+ T cells, and dendritic cells. GSEA enrichment analysis revealed significant differences in high- and low-risk groups in pathways like pentose phosphate pathway, ubiquitin mediated proteolysis, and P53 signaling pathway. This study helps to treat LUAD patients and explore molecules related to LUAD immune infiltration to deeply understand the specific mechanism.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2021.681277
    DOI: 10.3389/fgene.2021.681277.s001
    DOI: 10.3389/fgene.2021.681277.s002
    DOI: 10.3389/fgene.2021.681277.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 3
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    Tumor-promoting roles of HMMR in lung adenocarcinoma
    Elsevier BV ; 2023
    In:  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Vol. 826 ( 2023-01), p. 111811-
    Details
    In: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier BV, Vol. 826 ( 2023-01), p. 111811-
    Type of Medium: Online Resource
    ISSN: 0027-5107
    URL: Article
    DOI: 10.1016/j.mrfmmm.2022.111811
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1491099-8
    SSG: 12
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  • 4
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    Is it necessary for clinical tumor volume including neck muscles in target volume delineation of nasopharyngeal carcinoma?
    Wiley ; 2021
    In:  Laryngoscope Investigative Otolaryngology Vol. 6, No. 6 ( 2021-12), p. 1353-1357
    Details
    In: Laryngoscope Investigative Otolaryngology, Wiley, Vol. 6, No. 6 ( 2021-12), p. 1353-1357
    Abstract: To calculate the shrinkage of the neck muscles and dosimetric changes and to clarify the necessity of covering part of the muscle in neck node region delineation for patients with nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy. Methods In total, 44 patients with NPC were enrolled. Distances between the lateral border of the neck muscles and longitudinal midline were measured on every selected slice. This process was repeated three times, and the mean values of the three distances of planning computed tomography (CT) images and repeated CT images were adopted (labeled d 1 and d 2). The mean value of the differences between d 1 and d 2 was regarded as the medial shrinkage of the neck muscles. The initial clinical target volume of cervical lymph nodes (CTV‐n) was shifted medially with the value of shrinkage, yielding a new CTV‐n. Doses that covered 95% of the planning tumor volume (PTV) (D95), 99% of the PTV (D99), mean dose (Dmean), and maximum dose (Dmax) were used to calculate the dosimetric variation between the initial and new CTV‐n. Comparisons were performed using the paired samples t test. Results The median d 1 was 3.81 cm (range: 1.19‐8.20 cm), and the median d 2 was 3.68 cm (range: 0.94‐9.59 cm), with a statistically significant difference ( P   〈  .001). The mean difference between d 1 and d 2 was 1.5 ± 3.1 mm ( SD ). The D95 and D99 of PTV of initial CTV‐n decreased by 0.38% and 0.62% ( P   〈  .001 and P   〈  .001, respectively). Conclusion Patients with NPC experienced medial shrinkage of the neck muscles by 1.5 mm, and the consequent dose variation was negligible. It is unnecessary to cover part of the muscles in the delineation of the CTV‐n.
    Type of Medium: Online Resource
    ISSN: 2378-8038 , 2378-8038
    URL: Issue
    URL: Article
    DOI: 10.1002/lio2.v6.6
    DOI: 10.1002/lio2.691
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2851702-7
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  • 5
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    The clinical significance of preoperative serum triglyceride, high-density lipoprotein, and low-density lipoprotein levels in lung squamous cell carcinoma
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-10-07)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-10-07)
    Abstract: To evaluate the prognostic role of the preoperative plasma lipid profile, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in patients with lung squamous cell carcinoma (LUSC) who underwent complete resection. Clinical data, including preoperative plasma profile levels, were retrospectively collected and reviewed in 300 patients with LUSC who underwent radical lung resection between 2016 and 2017. The overall survival (OS) and disease-free survival (DFS) were assessed by the Kaplan–Meier method and the Cox proportional hazards regression model. TG ≤ 1.35, HDL-C ≤ 1.17, and LDL-C ≤ 2.32 were deemed as independent preoperative risk factors for OS, and HDL-C ≤ 1.17 was an independent preoperative risk factor for DFS. In the multivariate analyses involving OS and DFS, a decreased HDL-C level was significantly associated with worse OS (HR, 0.546; 95% CI, 0.380–0.784, P = 0.001) and DFS (HR, 0.644; 95% CI, 0.422–0.981, P = 0.041). Additionally, an increased TG (HR, 0.546; 95% CI, 0.366–0.814, P = 0.003) or LDL-C (HR, 0.652; 95% CI, 0.456–0.933, P = 0.019) level was significantly associated with better OS. In patients with LUSC, decreased levels of HDL-C may predict worse outcomes for both DFS and OS, while increased TG or LDL-C levels may predict better OS.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-18589-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 6
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    Synthesis and aggregation behavior of amphiphilic nanostructures composed of carbosilane dendrimer with peripheral poly(ethylene glycol) moieties
    Wiley ; 2014
    In:  Polymer International Vol. 63, No. 10 ( 2014-10), p. 1875-1880
    Details
    In: Polymer International, Wiley, Vol. 63, No. 10 ( 2014-10), p. 1875-1880
    Abstract: Dendritic amphiphiles as novel building blocks are very important for self‐assembling in the supramolecular chemistry area. In this work, a carbosilane dendrimer with hexamethylene as the branching unit ( G1 ) was first synthesized as a hydrophobic core and then linked with poly(ethylene glycol) ( PEG ) units as the periphery by a hydrosilylation reaction to prepare an amphiphilic dendrimer ( G1‐PEG ) with a yield of 27%. The aggregation behavior of G1‐PEG in water was studied with surface tension, dynamic light scattering and transmission electron microscopy methods. The surface tension data showed that the critical aggregation concentration of such dendrimers in water is approximately 0.75 g L −1 . The results of dynamic light scattering and transmission electron microscopy indicated that the aggregate size of G1‐PEG dendrimers in water is related to the concentration. Small micelles of about 10 nm were found at high concentration, large vesicles of about 100 nm were observed at low concentration, and a mixture of micelles and vesicles was found at middle concentrations. The encapsulation of G1‐PEG to a fluorescence probe verified the existence of a hydrophobic microenvironment in the aggregates at high concentrations of the amphiphilic dendrimer. © 2014 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0959-8103 , 1097-0126
    URL: Issue
    URL: Article
    DOI: 10.1002/pi.2014.63.issue-10
    DOI: 10.1002/pi.4725
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2004753-8
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  • 7
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    Construction of a prognostic risk assessment model for lung adenocarcinoma based on Integrin β family‐related genes
    Wiley ; 2022
    In:  Journal of Clinical Laboratory Analysis Vol. 36, No. 6 ( 2022-06)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 36, No. 6 ( 2022-06)
    Abstract: Integrin β (ITGB) superfamily plays an essential role in the intercellular connection and signal transmission. It was exhibited that overexpressing of ITGB family members promotes the malignant progression of lung adenocarcinoma (LUAD), but the relationship between ITGB superfamily and the LUAD prognosis remains unclear. Methods In this study, the samples were assigned to different subgroups utilizing non‐negative matrix factorization clustering according to the expression of ITGB family members in LUAD. Kaplan–Meier (K‐M) survival analysis revealed the significant differences in the prognosis between different ITGB subgroups. Subsequently, we screened differentially expressed genes among different subgroups and conducted univariate Cox analysis, random forest feature selection, and multivariate Cox analysis. 9‐feature genes (FAM83A, AKAP12, PKP2, CYP17A1, GJB3, TMPRSS11F, KRT81, MARCH4, and STC1) in the ITGB superfamily were selected to establish a prognostic assessment model for LAUD. Results In accordance with the median risk score, LUAD samples were divided into high‐ and low‐risk groups. The receiver operating characteristic (ROC) curve of LUAD patients’ survival was predicted via K‐M survival curve and principal component analysis dimensionality reduction. This model was found to have a favorable performance in LUAD prognostic assessment. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of differentially expressed genes between groups and Gene Set Enrichment Analysis (GSEA) of intergroup samples confirmed that the high‐ and low‐risk groups had evident differences mainly in the function of extracellular matrix (ECM) interaction. Risk score and univariate and multivariate Cox regression analyses of clinical factors showed that the prognostic model could be applied as an independent prognostic factor for LUAD. Then, we draw the nomogram of 1‐, 3‐, and 5‐year survival of LUAD patients predicted with the risk score and clinical factors. Calibration curve and clinical decision curve proved the favorable predictive ability of nomogram. Conclusion We constructed a LUAD prognostic risk model based on the ITGB superfamily, which can provide guidance for clinicians on their prognostic judgment.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v36.6
    DOI: 10.1002/jcla.24419
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001635-9
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  • 8
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    Image_1.tif
    Frontiers Media SA ; 2020
    In:  Frontiers in Bioengineering and Biotechnology Vol. 8 ( 2020-2-20)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 8 ( 2020-2-20)
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    URL: Article
    DOI: 10.3389/fbioe.2020.00075
    DOI: 10.3389/fbioe.2020.00075.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2719493-0
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  • 9
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    Zinc-Ion Storage Mechanism of Polyaniline for Rechargeable Aqueous Zinc-Ion Batteries
    MDPI AG ; 2022
    In:  Nanomaterials Vol. 12, No. 9 ( 2022-04-23), p. 1438-
    Details
    In: Nanomaterials, MDPI AG, Vol. 12, No. 9 ( 2022-04-23), p. 1438-
    Abstract: Aqueous multivalent ion batteries, especially aqueous zinc-ion batteries (ZIBs), have promising energy storage application due to their unique merits of safety, high ionic conductivity, and high gravimetric energy density. To improve their electrochemical performance, polyaniline (PANI) is often chosen to suppress cathode dissolution. Herein, this work focuses on the zinc ion storage behavior of a PANI cathode. The energy storage mechanism of PANI is associated with four types of protonated/non-protonated amine or imine. The PANI cathode achieves a high capacity of 74 mAh g−1 at 0.3 A g−1 and maintains 48.4% of its initial discharge capacity after 1000 cycles. It also demonstrates an ultrahigh diffusion coefficient of 6.25 × 10−9~7.82 × 10−8 cm−2 s−1 during discharging and 7.69 × 10−10~1.81 × 10−7 cm−2 s−1 during charging processes, which is one or two orders of magnitude higher than other reported studies. This work sheds a light on developing PANI-composited cathodes in rechargeable aqueous ZIBs energy storage devices.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano12091438
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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  • 10
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    The Synthesis of Manganese Hydroxide Nanowire Arrays for a High-Performance Zinc-Ion Battery
    MDPI AG ; 2022
    In:  Nanomaterials Vol. 12, No. 15 ( 2022-07-22), p. 2514-
    Details
    In: Nanomaterials, MDPI AG, Vol. 12, No. 15 ( 2022-07-22), p. 2514-
    Abstract: The morphology, microstructure as well as the orientation of cathodic materials are the key issues when preparing high-performance aqueous zinc-ion batteries (ZIBs). In this paper, binder-free electrode Mn(OH)2 nanowire arrays were facilely synthesized via electrodeposition. The nanowires were aligned vertically on a carbon cloth. The as-prepared Mn(OH)2 nanowire arrays were used as cathode to fabricate rechargeable ZIBs. The vertically aligned configuration is beneficial to electron transport and the free space between the nanowires can provide more ion-diffusion pathways. As a result, Mn(OH)2 nanowire arrays yield a high specific capacitance of 146.3 Ma h g−1 at a current density of 0.5 A g−1. They also demonstrates ultra-high diffusion coefficients of 4.5 × 10−8~1.0 × 10−9 cm2 s−1 during charging and 1.0 × 10−9~2.7 × 10−11 cm−2 s−1 during discharging processes, which are one or two orders of magnitude higher than what is reported in the studies. Furthermore, the rechargeable Zn//Mn(OH)2 battery presents a good capacity retention of 61.1% of the initial value after 400 cycles. This study opens a new avenue to boost the electrochemical kinetics for high-performance aqueous ZIBs.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    URL: Article
    DOI: 10.3390/nano12152514
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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