In:
Small, Wiley, Vol. 18, No. 1 ( 2022-01)
Abstract:
Fluorophores with emission in the second near‐infrared (NIR‐II) window have displayed salient advantages for biomedical applications. However, exploration of new luminogens with high NIR‐II fluorescent brightness is still challenging. Herein, based on the “ring‐fusion” strategy, a series of heteroatom‐inserted rigid‐planar cores is proposed to achieve the bathochromic NIR‐II fluorophores with aggregation‐induced emission (AIE) performance. Interestingly, one of the representative fluorophores, 4,4′‐(5,5′‐([1,2,5]thiadiazolo[3,4‐ i ]dithieno[2,3‐a:3′,2′‐ c ]phenazine‐8,12‐diyl)bis(4‐octylthiophene‐5,2‐diyl))bis( N , N ‐diphenylaniline) (TTQiT), enjoys a maximum emission beyond 1100 nm because of the efficiently narrowed energy bandgap by electron‐rich sulfur‐atom‐inserted core, which is verified by theoretical calculation. Taking advantage of the bright NIR‐II emission of TTQiT nanoparticles, the desirable in vivo NIR‐II imaging with high signal‐to‐background ratios is successfully performed and a long‐term stem cell tracking in the detection of acute lung injury is further realized. Therefore, it is anticipated that this work will provide a promising molecular engineering strategy to enrich the scope of NIR‐II fluorophores for catering to diverse demands in biomedical applications.
Type of Medium:
Online Resource
ISSN:
1613-6810
,
1613-6829
DOI:
10.1002/smll.202105362
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2168935-0
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