In:
Clinical Chemistry and Laboratory Medicine, Walter de Gruyter GmbH, Vol. 47, No. 3 ( 2009-01-01)
Abstract:
: Metabolomic studies have been applied to disease biomarkers selection. With the metabolomic technique, gas chromatography/mass spectrometry (GC/MS), human serum metabolites can be detected and identified. The purpose of this study was to investigate the serum metabolic profile of hepatitis B virus (HBV) infected cirrhosis patients and to detect disease biomarkers. : HBV infected non-cirrhosis male subjects (n=20) and HBV infected cirrhosis male patients (n=20) participated in this experiment. Serum metabolome was detected through chemical derivatization followed by GC/MS. The high-flux metabolomic data were analyzed by stepwise discriminant analysis. : Out of the 41 metabolites detected in serum, we selected metabolites, including acetic acid, sorbitol, D-lactic acid, hexanoic acid, 1-naphthalenamine, butanoic acid, phosphoric acid, D-glucitol, and glucose, which in combination with each other could segregate the two groups. The error count was 0% for the non-cirrhosis group and 25% for the cirrhosis group. : This technique can be used to select biomarkers for hepatic cirrhosis. Clin Chem Lab Med 2009;47:305–10.
Type of Medium:
Online Resource
ISSN:
1437-4331
,
1434-6621
DOI:
10.1515/CCLM.2009.083
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2009
detail.hit.zdb_id:
1492732-9
SSG:
15,3
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