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  • 1
    Online Resource
    Online Resource
    Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of Pancreatology Vol. 4, No. 2 ( 2021-06-7), p. 49-66
    Details
    In: Journal of Pancreatology, Ovid Technologies (Wolters Kluwer Health), Vol. 4, No. 2 ( 2021-06-7), p. 49-66
    Abstract: The incidence of pancreatic cancer has been rising worldwide, and its clinical diagnosis and treatment remain a great challenge. To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years, Chinese Pancreatic Association, the Chinese Society of Surgery, Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China (2014) after reviewing evidence-based and problem-oriented literature published during 2015–2021, mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer, conversion strategies for locally advanced pancreatic cancer, treatment of pancreatic cancer with oligo metastasis, adjuvant and neoadjuvant therapy, standardized processing of surgical specimens and evaluation of surgical margin status, systemic treatment for unresectable pancreatic cancer, genetic testing, as well as postoperative follow up of patients with pancreatic cancer. Forty recommendation items were finally proposed based on the above issues, and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation, Assessment, Development, and Evaluation system. This guideline aims to standardize the clinical diagnosis and therapy, especially surgical treatment of pancreatic cancer in China, and further improve the prognosis of patients with pancreatic cancer.
    Type of Medium: Online Resource
    ISSN: 2096-5664 , 2577-3577
    URL: Article
    DOI: 10.1097/JP9.0000000000000072
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2964149-4
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  • 2
    Online Resource
    Online Resource
    Table_1.xlsx
    Frontiers Media SA ; 2020
    In:  Frontiers in Genetics Vol. 11 ( 2020-6-23)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 11 ( 2020-6-23)
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2020.00612
    DOI: 10.3389/fgene.2020.00612.s001
    DOI: 10.3389/fgene.2020.00612.s002
    DOI: 10.3389/fgene.2020.00612.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2606823-0
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  • 3
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    Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition)
    S. Karger AG ; 2022
    In:  Liver Cancer Vol. 11, No. 6 ( 2022), p. 511-526
    Details
    In: Liver Cancer, S. Karger AG, Vol. 11, No. 6 ( 2022), p. 511-526
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Hepatocellular carcinoma (HCC) is one of the most common malignancies in China. Most HCC patients are first diagnosed at an advanced stage, and systemic treatments are the mainstay of treatment. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 In recent years, immune checkpoint inhibitors have made a breakthrough in the systemic treatment of middle-advanced HCC, breaking the single therapeutic pattern of molecular-targeted agents. To better guide the clinical treatment for effective and safe use of immunotherapeutic drugs, the Chinese Association of Liver Cancer and Chinese Medical Doctor Association has gathered multidisciplinary experts and scholars in relevant fields to formulate the “Chinese Clinical Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021)” based on current clinical studies and clinical medication experience for reference in China. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 The consensus contained 17 recommendations, including the preferred regimen for first- and second-line immunotherapy, evaluation and monitoring before/during/after treatment, management of complications, precautions for special patients, and potential population for immunotherapy.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000526038
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2666925-0
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  • 4
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    Guidelines for Diagnosis and Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus in China (2021 Edition)
    S. Karger AG ; 2022
    In:  Liver Cancer Vol. 11, No. 4 ( 2022), p. 315-328
    Details
    In: Liver Cancer, S. Karger AG, Vol. 11, No. 4 ( 2022), p. 315-328
    Abstract: Portal vein tumor thrombus (PVTT) is very common and it plays a major role in the prognosis and clinical staging of hepatocellular carcinoma (HCC). We have published the first version of the guideline in 2016 and revised in 2018. Over the past several years, many new evidences for the treatment of PVTT become available, especially for the advent of new targeted drugs and immune checkpoint inhibitors which have further improved the prognosis of PVTT. So, the Chinese Association of Liver Cancer and Chinese Medical Doctor Association revised the 2018 version of the guideline to adapt to the development of PVTT treatment. Future treatment strategies for HCC with PVTT in China would depend on new evidences from more future clinical trials.
    Type of Medium: Online Resource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000523997
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2666925-0
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  • 5
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    Study on Sentinel Lymph Node and Its Lymphatic Drainage Pattern of Breast Cancer by Contrast‐Enhanced Ultrasound
    Wiley ; 2022
    In:  Journal of Ultrasound in Medicine Vol. 41, No. 11 ( 2022-11), p. 2727-2737
    Details
    In: Journal of Ultrasound in Medicine, Wiley, Vol. 41, No. 11 ( 2022-11), p. 2727-2737
    Abstract: Sentinel lymph node (SLN) and its lymphatic drainage pattern (LDP) of breast cancer were studied by contrast‐enhanced ultrasound (CEUS). Methods From July 2017 to December 2019, patients with SLN localization of breast cancer in Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital were selected. The sentinel lymph system of breast cancer was observed by CEUS before both operation and blue staining in the surgery. The location, number, and route of sentinel lymphatic channel (SLC) were recorded, along with the number, size, and the depth from skin of SLN. LDPs were summarized according to these basic characteristics of SLC and SLN. Results A total of 368 cases were included; 465 SLCs and 423 SLNs were detected. Most of the SLCs were originated from the outer upper quadrant of areola. Eleven LDPs were found, including 31 subtypes of LDPs. There were 6 cases of type A (1.63%), 15 cases of type B (4.08%), 223 cases of type C (57.88%), 38 cases of type D (10.33%), 2 cases of type E (0.54%), 3 cases of type F (0.82%), 50 cases of type G (13.59%), 30 cases of type H (8.15%), 2 cases of type I (0.54%), 6 cases of type J (1.63%), and 3 cases of type K (0.82%). Conclusions The most common LDP of breast cancer was one SLC originated from the upper quadrant of areola with one SLN. CEUS can identify the LDP before surgery to reduce the false negative rate of SLN biopsy.
    Type of Medium: Online Resource
    ISSN: 0278-4297 , 1550-9613
    URL: Issue
    URL: Article
    DOI: 10.1002/jum.v41.11
    DOI: 10.1002/jum.15957
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2067124-6
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  • 6
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    The value of contrast‐enhanced ultrasound in determining the location of sentinel lymph nodes in breast cancer
    Springer Science and Business Media LLC ; 2021
    In:  Cancer Imaging Vol. 21, No. 1 ( 2021-12)
    Details
    In: Cancer Imaging, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: This study aimed to explore the sentinel lymph node (SLN) identification rate in breast cancer by subcutaneous and intradermal injection of ultrasound contrast agent in the mammary areola region, compared to the results achieved with methylene blue (MB). Methods A total of 390 breast cancer patients with planned sentinel lymph node biopsy from our breast surgery department from July 2017 to February 2019 were enrolled. All patients were subjected to preoperative contrast-enhanced ultrasound (CEUS), that involved an intracutaneous injection of 1 mL ultrasonic contrast agent (UCA) at 3 and 6 o ‘clock, as well as a subcutaneous injection of 1 mL UCA at 9 and 12 o’clock. The enhanced lymph nodes along the enhanced lymphatic vessels from the mammary areola were traced. The number of enhanced lymph nodes were recorded, and an ultrasound-guided injection of 1:10 diluted carbon nanoparticles were used to mark all first site enhanced lymph nodes (i.e., SLNs). An intraoperative dye method (MB) was used to track the SLNs and the results were compared with the CEUS findings. Results Among the 390 cases of breast cancer, enhanced SLNs were observed in 373 patients after an injection of UCA with an identification rate of 95.64 % (373/390), compared to the identification rate of 92.05 % (359/390) using the intraoperative MB. The difference between the two methods was statistically significant ( P  = 0.016). And among the 390 patients, a total of 808 enhanced lymph nodes were traced by preoperative CEUS, with a median of 2 (1,3). A total of 971 blue-stained lymph nodes were traced using the intraoperative MB, with a median of 2 (2,3), indicating a statistically significant difference ( p   〈  0.001). Conclusions Intradermal and subcutaneous injections of UCA in the mammary areola region may have clinical application value for the identification and localization of SLNs in breast cancer patients. The identification rate is higher than that of blue dye method, which can be used as a new tracer of sentinel lymph node biopsy and complement other staining methods to improve the success rate.
    Type of Medium: Online Resource
    ISSN: 1470-7330
    URL: Article
    DOI: 10.1186/s40644-021-00397-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2104862-9
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  • 7
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    Mid-Cretaceous aeolian desert systems in the Yunlong area of the Lanping Basin, China: Implications for palaeoatmosphere dynamics and paleoclimatic change in East Asia
    Elsevier BV ; 2018
    In:  Sedimentary Geology Vol. 364 ( 2018-02), p. 121-140
    Details
    In: Sedimentary Geology, Elsevier BV, Vol. 364 ( 2018-02), p. 121-140
    Type of Medium: Online Resource
    ISSN: 0037-0738
    URL: Article
    DOI: 10.1016/j.sedgeo.2017.12.014
    RVK:
    RA 1000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 216739-6
    detail.hit.zdb_id: 2012818-6
    SSG: 13
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  • 8
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    Cretaceous mountain building processes triggered the aridification and drainage evolution in east Asia
    Geological Society of America ; 2023
    In:  Geological Society of America Bulletin ( 2023-09-11)
    Details
    In: Geological Society of America Bulletin, Geological Society of America, ( 2023-09-11)
    Abstract: Knowledge of the late Mesozoic topography and drainage system of the Tibetan Plateau is essential for understanding the Cenozoic tectonic dynamics of the plateau. However, systematic analyses of the pre-Cenozoic surface uplift history and sediment-routing systems of the Tibetan Plateau remain sparse. Here we present new results for paleocurrents and U-Pb detrital zircon geochronology from the Lanping Basin, a key junction in the southeastern (SE) Tibetan Plateau, and integrate multidisciplinary data sets to constrain sediment provenance and reconstruct paleotopography and its drainage system throughout the Cretaceous. Our results indicate that mid- to Late Cretaceous (ca. Albian−Santonian) tectonically induced surface uplift occurred in the SE Tibetan Plateau, leading to the build-up of an extensive topographic barrier, and resultant rain shadows in the interior of east Asia. Superimposition of this topographic pattern by uplands in the eastern margin of Asia meant that the Cretaceous topography of east Asia was characterized by an enclosed paleo-relief pattern that was high in both the east and west, with drainage from the east and west to the south, contrasting with previously proposed configurations. This topographic pattern interrupted the atmospheric circulation pattern and generated widespread intracontinental desertification and drainage network evolution in east Asia. Our study constrains a key part of the late Mesozoic growth of the Tibetan Plateau prior to the Cenozoic collision between India and Eurasia and will improve our understanding of the paleoclimate, atmospheric circulation, and modern drainage system evolution of the east Asian continent.
    Type of Medium: Online Resource
    ISSN: 0016-7606 , 1943-2674
    URL: Article
    DOI: 10.1130/B36763.1
    Language: English
    Publisher: Geological Society of America
    Publication Date: 2023
    detail.hit.zdb_id: 2028776-8
    detail.hit.zdb_id: 2008165-0
    detail.hit.zdb_id: 449720-X
    detail.hit.zdb_id: 1351-1
    SSG: 13
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  • 9
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    UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
    Springer Science and Business Media LLC ; 2024
    In:  Breast Cancer Research Vol. 26, No. 1 ( 2024-03-11)
    Details
    In: Breast Cancer Research, Springer Science and Business Media LLC, Vol. 26, No. 1 ( 2024-03-11)
    Abstract: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore the deubiquitination substrates of UCHL1 related to endocrine therapeutic responses and the mechanisms of UCHL1 dysregulation in TNBC. Methods Bioinformatics analysis was conducted using online open databases. TNBC representative MDA-MB-468 and SUM149 cells were used for in vitro and in-vivo studies. Co-immunoprecipitation was used to explore the interaction between UCHL1 and KLF5 and UCHL1-mediated KIF5 deubiquitination. CCK-8, colony formation and animal studies were performed to assess endocrine therapy responses. The regulatory effect of TET1/3 on UCHL1 promoter methylation and transcription was performed by Bisulfite sequencing PCR and ChIP-qPCR. Results UCHL1 interacts with KLF5 and stabilizes KLF5 by reducing its polyubiquitination and proteasomal degradation. The UCHL1-KLF5 axis collaboratively upregulates EGFR expression while downregulating ESR1 expression at both mRNA and protein levels in TNBC. UCHL1 knockdown slows the proliferation of TNBC cells and sensitizes the tumor cells to Tamoxifen and Fulvestrant. KLF5 overexpression partially reverses these trends. Both TET1 and TET3 can bind to the UCHL1 promoter region, reducing methylation of associated CpG sites and enhancing UCHL1 transcription in TNBC cell lines. Additionally, TET1 and TET3 elevates KLF5 protein level in a UCHL1-dependent manner. Conclusion UCHL1 plays a pivotal role in TNBC by deubiquitinating and stabilizing KLF5, contributing to endocrine therapy resistance. TET1 and TET3 promote UCHL1 transcription through promoter demethylation and maintain KLF5 protein level in a UCHL1-dependent manner, implying their potential as therapeutic targets in TNBC.
    Type of Medium: Online Resource
    ISSN: 1465-542X
    URL: Article
    DOI: 10.1186/s13058-024-01800-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2041618-0
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  • 10
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    Absolute frequency measurement of the 87 Sr optical lattice clock at NTSC using international atomic time
    IOP Publishing ; 2023
    In:  Metrologia Vol. 60, No. 1 ( 2023-02-01), p. 015008-
    Details
    In: Metrologia, IOP Publishing, Vol. 60, No. 1 ( 2023-02-01), p. 015008-
    Abstract: We report the absolute frequency measurement of the 5 s 2 1 S 0 → 5 s 5 p 3 P 0 transition in 87 Sr optical lattice clock (Sr1) at National Time Service Center. Its systematic frequency shifts are evaluated carefully with a total relative uncertainty of 5.1 × 10 − 17 . The measured absolute frequency is 429 228 004 229 872.91(18) Hz with a relative uncertainty of 4.1 × 10 − 16 , with reference to the ensemble of primary and secondary frequency standards published in the Circular T bulletin by BIPM through a global navigation satellite system link.
    Type of Medium: Online Resource
    ISSN: 0026-1394 , 1681-7575
    URL: Article
    DOI: 10.1088/1681-7575/acb05c
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 1460891-1
    SSG: 11
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