In:
Chemistry – A European Journal, Wiley, Vol. 27, No. 30 ( 2021-05-26), p. 8040-8047
Abstract:
6‐Cyano‐7‐aminoquinoline (6CN−7AQ ) and 3‐cyano‐7‐aminoquinoline ( 3CN−7AQ ) were synthesized and found to exhibit intense emission with quantum yield as high as 63 % and 85 %, respectively, in water. Conversely, their derivatives 6‐cyano‐7‐azidoquinoline (6CN−7N 3 Q ) and 3‐cyano‐7‐azidoquinoline ( 3CN−7N 3 Q ) show virtually no emission, which makes them suitable to be used as recognition agents in azide reactions based on fluorescence recovery. Moreover, conjugation of 6CN−7AQ with a hydrophobic biomembrane‐penetration peptide PFVYLI renders a nearly non‐emissive 6CN−7AQ‐PFVYLI composite, which can be digested by proteinase K, recovering the highly emissive 6CN−7AQ with ∼200‐fold enhancement. The result provides an effective early confirmation for RT‐qPCR in viral detection.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202100413
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1478547-X
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