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  • 1
    Online-Ressource
    Online-Ressource
    Recognition by Tryptophanyl-tRNA Synthetases of Discriminator Base on tRNATrp from Three Biological Domains
    Elsevier BV ; 2002
    In:  Journal of Biological Chemistry Vol. 277, No. 16 ( 2002-04), p. 14343-14349
    Details
    In: Journal of Biological Chemistry, Elsevier BV, Vol. 277, No. 16 ( 2002-04), p. 14343-14349
    Materialart: Online-Ressource
    ISSN: 0021-9258
    URL: Article
    DOI: 10.1074/jbc.M111745200
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2002
    ZDB Id: 2141744-1
    ZDB Id: 1474604-9
    SSG: 12
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  • 2
    Online-Ressource
    Online-Ressource
    3D-QSAR Model of Flavonoids Binding at Benzodiazepine Site in GABA A Receptors
    American Chemical Society (ACS) ; 2001
    In:  Journal of Medicinal Chemistry Vol. 44, No. 12 ( 2001-06-01), p. 1883-1891
    Details
    In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 44, No. 12 ( 2001-06-01), p. 1883-1891
    Materialart: Online-Ressource
    ISSN: 0022-2623 , 1520-4804
    URL: Article
    DOI: 10.1021/jm000557p
    Sprache: Englisch
    Verlag: American Chemical Society (ACS)
    Publikationsdatum: 2001
    ZDB Id: 1491411-6
    SSG: 15,3
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  • 3
    Online-Ressource
    Online-Ressource
    Inhibitor-Induced Shift-Downs in Escherichia coli
    American Society for Microbiology ; 1969
    In:  Journal of Bacteriology Vol. 100, No. 2 ( 1969-11), p. 956-961
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 100, No. 2 ( 1969-11), p. 956-961
    Kurzfassung: A shift-down response in Escherichia coli cells has been brought about by moderate concentrations of azide or cyanide. Early events of the response included a preferential inhibition of ribonucleic acid relative to deoxyribonucleic acid synthesis, a degradation of polyribosomes, and an inhibition of protein synthesis followed by a transient relief. These changes were entirely comparable to those observed with nutrient-induced shift-downs. The influences of various nutrient supplements on an azide shift-down were examined, and methionine was found to relieve effectively the inhibition of ribonucleic acid synthesis in some strains of cells.
    Materialart: Online-Ressource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/jb.100.2.956-961.1969
    Sprache: Englisch
    Verlag: American Society for Microbiology
    Publikationsdatum: 1969
    ZDB Id: 1481988-0
    SSG: 12
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  • 4
    Online-Ressource
    Online-Ressource
    Nature of Ribosome-Bound β-Galactosidase
    American Society for Microbiology ; 1971
    In:  Journal of Bacteriology Vol. 105, No. 2 ( 1971-02), p. 498-503
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 105, No. 2 ( 1971-02), p. 498-503
    Kurzfassung: Properties of the ribosome-bound β-galactosidase were examined in Escherichia coli cells after prolonged induction. This fraction of enzyme was not chased from ribosomes by removal of inducer, or by treatments with hydroxylamine, puromycin, chloramphenicol, and azide. However, the metabolic turnover of this fraction could be demonstrated by means of a pulsed exposure to the phenylalanine analogue β-2-thienylalanine, and this fraction was enriched in heavy forms relative to the soluble enzyme. These observations indicated a tight coupling of the release of ribosome-bound enzyme to nascent enzyme synthesis, and it is suggested that the ribosome-bound enzyme is related to an intermediate stage in the assembly of quarternary enzyme structures.
    Materialart: Online-Ressource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/jb.105.2.498-503.1971
    Sprache: Englisch
    Verlag: American Society for Microbiology
    Publikationsdatum: 1971
    ZDB Id: 1481988-0
    SSG: 12
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  • 5
    Online-Ressource
    Online-Ressource
    QUANTITATIVE CHROMATOGRAPHIC METHODS: PART 6. IMPROVED PROCEDURE FOR DETERMINATION OF AMINO COMPOUNDS ON PAPER CHROMATOGRAMS
    Canadian Science Publishing ; 1961
    In:  Canadian Journal of Biochemistry and Physiology Vol. 39, No. 2 ( 1961-02-01), p. 427-437
    Details
    In: Canadian Journal of Biochemistry and Physiology, Canadian Science Publishing, Vol. 39, No. 2 ( 1961-02-01), p. 427-437
    Kurzfassung: A procedure is described for the quantitative determination of amino compounds separated by paper chromatography. The procedure is of general applicability, and more specifically has been extensively applied to the standard P-E-PP and P-E-T chromatograms. Recovery data from these chromatograms have been obtained, and the various factors influencing the accuracy of analysis are discussed.
    Materialart: Online-Ressource
    ISSN: 0576-5544
    URL: Article
    DOI: 10.1139/o61-041
    Sprache: Englisch
    Verlag: Canadian Science Publishing
    Publikationsdatum: 1961
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  • 6
    Online-Ressource
    Online-Ressource
    Recognition of 'Early' and 'Late' Biosynthetic Classes of Ribosomal Proteins in Escherichia coli
    Canadian Science Publishing ; 1971
    In:  Canadian Journal of Biochemistry Vol. 49, No. 12 ( 1971-12-01), p. 1276-1278
    Details
    In: Canadian Journal of Biochemistry, Canadian Science Publishing, Vol. 49, No. 12 ( 1971-12-01), p. 1276-1278
    Kurzfassung: When cells of a pyrimidine-requiring strain of Escherichia coli were starved of uridine, there occurred a sequential turn-off in the synthesis of different ribosomal proteins. This observation provided a basis for distinguishing between ribosomal proteins exhibiting an 'early' turn-off from those exhibiting a 'late' turn-off. Both the 'early' and 'late' classes were represented on both the 30 S and 50 S subunits, but the 30 S subunit was enriched in 'early' ribosomal proteins relative to the 50 S subunit.
    Materialart: Online-Ressource
    ISSN: 0008-4018
    URL: Article
    DOI: 10.1139/o71-184
    Sprache: Englisch
    Verlag: Canadian Science Publishing
    Publikationsdatum: 1971
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  • 7
    Online-Ressource
    Online-Ressource
    Low-affinity interaction of ethanol with the fluorescent complex between horse liver alcohol dehydrogenase and auramine O
    Canadian Science Publishing ; 1976
    In:  Canadian Journal of Biochemistry Vol. 54, No. 3 ( 1976-03-01), p. 287-290
    Details
    In: Canadian Journal of Biochemistry, Canadian Science Publishing, Vol. 54, No. 3 ( 1976-03-01), p. 287-290
    Kurzfassung: Quenching of the fluorescence of the complex between horse liver alcohol dehydrogenase (alcohol:NAD + oxidoreductase (EC 1.1.1.1)) and auramine O complex is inconsistent with a simple competitive displacement of auramine O by ethanol. Instead, the action of ethanol requires an explanation in terms of a solvent effect, or the formation of an enzyme – auramine O – ethanol ternary complex. The latter complex would have to be the low-affinity variety similar to the enzyme–NADH–ethanol ternary complex encountered in the kinetic system.
    Materialart: Online-Ressource
    ISSN: 0008-4018
    URL: Article
    DOI: 10.1139/o76-042
    Sprache: Englisch
    Verlag: Canadian Science Publishing
    Publikationsdatum: 1976
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  • 8
    Online-Ressource
    Online-Ressource
    KINETIC FORMULATIONS FOR ENZYMIC REACTIONS INVOLVING TWO SUBSTRATES
    Canadian Science Publishing ; 1962
    In:  Canadian Journal of Biochemistry and Physiology Vol. 40, No. 6 ( 1962-06-01), p. 763-804
    Details
    In: Canadian Journal of Biochemistry and Physiology, Canadian Science Publishing, Vol. 40, No. 6 ( 1962-06-01), p. 763-804
    Kurzfassung: The general mechanism for enzymic group-transfer reactions is shown to be of considerable complexity. In order to deal with this complexity, an analysis has been made of the structure of steady-state rate equations, which permits the establishment of direct relationships between specified features of mechanism and of rate behavior. This has opened up the possibility of a featurewise approach for the progressive elucidation of complex enzymic mechanisms. In particular, a theoretical basis has been provided for the comprehensive consideration and systematic differentiation of mechanisms of enzymic group-transfer reactions.
    Materialart: Online-Ressource
    ISSN: 0576-5544
    URL: Article
    DOI: 10.1139/o62-089
    Sprache: Englisch
    Verlag: Canadian Science Publishing
    Publikationsdatum: 1962
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  • 9
    Online-Ressource
    Online-Ressource
    Descent of Bacteria and Eukarya From an Archaeal Root of Life
    SAGE Publications ; 2020
    In:  Evolutionary Bioinformatics Vol. 16 ( 2020-01), p. 117693432090826-
    Details
    In: Evolutionary Bioinformatics, SAGE Publications, Vol. 16 ( 2020-01), p. 117693432090826-
    Kurzfassung: The 3 biological domains delineated based on small subunit ribosomal RNAs (SSU rRNAs) are confronted by uncertainties regarding the relationship between Archaea and Bacteria, and the origin of Eukarya. The similarities between the paralogous valyl-tRNA and isoleucyl-tRNA synthetases in 5398 species estimated by BLASTP, which decreased from Archaea to Bacteria and further to Eukarya, were consistent with vertical gene transmission from an archaeal root of life close to Methanopyrus kandleri through a Primitive Archaea Cluster to an Ancestral Bacteria Cluster, and to Eukarya. The predominant similarities of the ribosomal proteins (rProts) of eukaryotes toward archaeal rProts relative to bacterial rProts established that an archaeal parent rather than a bacterial parent underwent genome merger with bacteria to generate eukaryotes with mitochondria. Eukaryogenesis benefited from the predominantly archaeal accelerated gene adoption (AGA) phenotype pertaining to horizontally transferred genes from other prokaryotes and expedited genome evolution via both gene-content mutations and nucleotidyl mutations. Archaeons endowed with substantial AGA activity were accordingly favored as candidate archaeal parents. Based on the top similarity bitscores displayed by their proteomes toward the eukaryotic proteomes of Giardia and Trichomonas, and high AGA activity, the Aciduliprofundum archaea were identified as leading candidates of the archaeal parent. The Asgard archaeons and a number of bacterial species were among the foremost potential contributors of eukaryotic-like proteins to Eukarya.
    Materialart: Online-Ressource
    ISSN: 1176-9343 , 1176-9343
    URL: Article
    DOI: 10.1177/1176934320908267
    Sprache: Englisch
    Verlag: SAGE Publications
    Publikationsdatum: 2020
    ZDB Id: 2227610-5
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  • 10
    Online-Ressource
    Online-Ressource
    Kinetic Mechanism for the Major Isoenzyme of Horse Liver Alcohol Dehydrogenase
    Canadian Science Publishing ; 1972
    In:  Canadian Journal of Biochemistry Vol. 50, No. 12 ( 1972-12-01), p. 1385-1413
    Details
    In: Canadian Journal of Biochemistry, Canadian Science Publishing, Vol. 50, No. 12 ( 1972-12-01), p. 1385-1413
    Kurzfassung: The reaction mechanism for the major isoenzyme C 1 of the alcohol dehydrogenase (EC 1.1.1.1) of horse liver has been established through kinetic analysis utilizing direct correlations between rate and mechanistic features. The mechanism consists of random sequences of reaction of the enzyme with ethanol and NAD, and an obligatory sequence of reaction with NADH and acetaldehyde. At high concentrations of ethanol or NADH, excess-ethanol and excess-NADH pathways become evident involving the formation of an enzyme/NADH/ethanol complex. Even after dissociation of NADH from this complex the enzyme/ethanol complex remains imprinted with an altered conformation and differs from the regular binary complex formed under conditions of low ethanol concentrations. A range of elementary rate constants pertaining to the binding and dissociation of reactants from binary as well as ternary complexes of the mechanism has been estimated by means of a combination of algebraic analysis, curve simulation, and sensitivity analysis.
    Materialart: Online-Ressource
    ISSN: 0008-4018
    URL: Article
    DOI: 10.1139/o72-182
    Sprache: Englisch
    Verlag: Canadian Science Publishing
    Publikationsdatum: 1972
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