In:
ChemistrySelect, Wiley, Vol. 2, No. 27 ( 2017-09-21), p. 8666-8672
Abstract:
Two β‐carboline rhenium(I) complexes, fac‐ [Re(CO) 3 (dppz)(nHo)]O 3 SCF 3 and fac ‐[Re(CO) 3 (nHo) 2 Cl] where dppz=dipyrido[3, 2‐a:2′,3′‐c] phenazine and nHo=9H‐pyrido[3, 4‐b]indole (norharmane), have been synthesized. These complexes were fully characterized by structural X‐ray diffraction, 1 H and 13 C NMR, UV‐vis absorption and FT‐IR spectroscopy and mass spectrometry. Ground state geometry optimization was carried out in vacuo with the PBE0 hybrid functional using the LanL2DZ basis set. The characterization was complemented with TD‐DFT calculations using several hybrid functionals. Cellular uptake and cytotoxic effect of both complexes against human lung carcinoma (A549) cells were evaluated. For comparative purpose, two related fac ‐[Re(CO) 3 (L)(nHo)] + complexes (L=bpy and phen) were included in the biological studies. The anti‐proliferative effect of the compounds was rationalized in terms of the different extension of the ligands π‐system.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201701961
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2844262-3
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