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  • 1
    Online Resource
    Online Resource
    Semantic decisions in adolescents with autism spectrum disorders - functional magnetic resonance imaging study
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2022
    In:  Psychiatria Polska Vol. 56, No. 5 ( 2022-10-31), p. 1079-1092
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 56, No. 5 ( 2022-10-31), p. 1079-1092
    Abstract: Goal: to assess fMRI activation during semantic tasks in adolescents with ASD. Methods Material: 44 right-handed male adolescents aged 12-19 (mean 14.3 ± 2.0) - 31 with autism spectrum disorders who met DSM-IV-TR criteria for Asperger's syndrome and 13 neurotypical adolescents matched according to age and handiness. Method: Functional testing (fMRI) was performed during semantic decisions tasks and phonological decisions in three categories of tasks: concrete nouns, verbs with plural meanings, words describing states of mind, as a control condition. Statistical analyzes were performed at the level of p 〈 0.05 with FWE (family-wise error) correction and p 〈 0.001. Results Results: lower BOLD signal was demonstrated in many brain areas including precuneus, posterior cingulate gyrus, angular gyrus, parahippocampal gyrus, regardless of task category and processing method in the ASD group. The smallest differences in semantic processing were found for concrete nouns and the greatest ones for words describing states of mind. Conclusions Conclusions: the presence of different activation patterns in the ASD group suggests that far more than just the areas traditionally attributed to language processing, are involved in semantic deficits in ASD.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Decyzje semantyczne u nastolatków z zaburzeniami ze spektrum autyzmu - badanie czynnościowym rezonansem magnetycznym
    URL: Article
    DOI: 10.12740/PP/OnlineFirst/133032
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2022
    detail.hit.zdb_id: 2833968-X
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  • 2
    Online Resource
    Online Resource
    Morphometric evaluations based on Voxel Based Morphometry on adolescents with autism spectrum disorders.
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2022
    In:  Psychiatria Polska Vol. 56, No. 5 ( 2022-10-31), p. 1049-1059
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 56, No. 5 ( 2022-10-31), p. 1049-1059
    Abstract: Goal: to evaluate changes in the grey matter volume using the VBM method in a group of adolescents with ASD, who met the criteria for Asperger’s Syndrome. Methods Material and methods: Morphometric evaluations based on Voxel Based Morphometry (VBM) were performed on 37 male adolescents aged 12 to 19 (M = 14.3 ± 2.0), with autism spectrum disorders, who met the DSM-IV-TR criteria for Asperger’s Syndrome and 15 neurotypical adolescents matched by age. Significance was set at p 〈 0.007 without FWE correction and p 〈 0.05 with FWE correction. Results Results: the decrease in the volume of the grey matter was observed in ASD group including the pre- and postcentral gyrus, the superior and middle frontal gyrus, the inferior and superior parietal lobule, the praecuneus, the anterior and posterior cingulate cortex, the fusiform gyrus, the parahippocampal gyrus, the lingual gyrus, the middle occipital region, the cuneus and the angular gyrus, the regions of calcarine sulcus and the cerebellum. The majority of changes was localized bilaterally. Conclusions Conclusions: the decrease in the volume of grey matter observed in ASD group can be related functionally with the characteristics of deficits observed in autism spectrum disorders which highlights the role of abnormal organization of numerous CNS structures in the genesis of symptoms observed in cognitive and behavioural domains.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Badania morfometryczne oparte o pomiar voksela (Voxel Based Morphometry) u nastolatków z zaburzeniami ze spektrum autyzmu
    URL: Article
    DOI: 10.12740/PP/OnlineFirst/132704
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2022
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  • 3
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    Online Resource
    Adolescent Outcome of Child ADHD in Primary Care Setting : Stability of Diagnosis
    SAGE Publications ; 2013
    In:  Journal of Attention Disorders Vol. 17, No. 8 ( 2013-11), p. 655-659
    Details
    In: Journal of Attention Disorders, SAGE Publications, Vol. 17, No. 8 ( 2013-11), p. 655-659
    Abstract: Objective: The aim of the study was to assess the functioning of patients with ADHD 6 to 7 years after the diagnosis. One objective was to determine the stability of diagnosis, symptoms decline, subtype change, remission, and change of diagnosis. Method: In all, 101 participants were chosen for testing. All were interviewed for the presence of ADHD and social, academic, and peer functioning, and completed Youth Self-Report. The caregivers completed a Wender Utah Rating Scale and Child Behavior Checklist, and were asked to assess the social, academic, and peer functioning of their offspring. Results: A total of 56% ( n = 57) still met the criteria for ADHD and 24.7% ( n = 25) still met the criteria for hyperkinetic disorder (HKD). Subtype migration was observed. In all, 7.7% ( n = 14) were rediagnosed with Asperger’s syndrome, 2.2% ( n = 4) received a diagnosis of bipolar disorder, 2.2% ( n = 4) were diagnosed with mental retardation, 1 with schizophrenia, and 1 with genetic disorder. Conclusion: The reliability of diagnosis was high. The rates of all subtypes of ADHD decreased. More measures need to be taken in terms of differential diagnosis of ADHD and Asperger’s Syndrome.
    Type of Medium: Online Resource
    ISSN: 1087-0547 , 1557-1246
    URL: Article
    DOI: 10.1177/1087054712437583
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2188086-4
    SSG: 5,2
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  • 4
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    Online Resource
    Overweight in Boys With ADHD Is Related to Candidate Genes and Not to Deficits in Cognitive Functions
    SAGE Publications ; 2018
    In:  Journal of Attention Disorders Vol. 22, No. 12 ( 2018-10), p. 1158-1172
    Details
    In: Journal of Attention Disorders, SAGE Publications, Vol. 22, No. 12 ( 2018-10), p. 1158-1172
    Abstract: Objective: The aim of the study was to assess the relationship of overweight, the polymorphisms of selected candidate genes, and deficits in the executive functions among children with ADHD. Method: We examined 109 boys with ADHD aged between 7 and 17 years. The study indicated variants of 14 polymorphisms in eight candidate genes. We applied seven neuropsychological tests to evaluate the executive functions. Overweight was diagnosed on the basis of the guidelines of the International Obesity Task Force. Results: Analyses revealed significant association between DRD4 rs1800955, SNAP25 rs363039 and rs363043, 5HTR2A rs17288723, and overweight in boys with ADHD. There were no significant differences in the level of neuropsychological test results between patients with overweight and without overweight. Conclusion: Overweight in boys with ADHD is associated with polymorphisms in three candidate genes: DRD4, SNAP25, and 5HTR2A, but not through conditioning deficits in cognitive functions.
    Type of Medium: Online Resource
    ISSN: 1087-0547 , 1557-1246
    URL: Article
    DOI: 10.1177/1087054716676364
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2188086-4
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  • 5
    Online Resource
    Online Resource
    Psychiatric, behavioral and emotional disorders in Polish children and adolescents with perinatal HIV infection
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2021
    In:  Psychiatria Polska Vol. 55, No. 6 ( 2021-12-31), p. 1387-1404
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 55, No. 6 ( 2021-12-31), p. 1387-1404
    Abstract: The aims of the study were to evaluate the prevalence of psychiatric, behavioral and emotional disorders in children and adolescents with perinatal HIV infection and to establish their possible relationships with clinical and sociodemographic variables. Methods 56 children with perinatal HIV infection (PHIV+ group), 24 healthy children perinatally HIV-exposed but uninfected (PHEU) and 43 healthy children of uninfected parents (HIV-nA), aged 6–18 years, were assessed. The Child Behavior Checklist (CBCL/4–18), completed by parents, and the Youth Self-Report (YSR) were used to assess behavioral and emotional disorders, while the semi-structured diagnostic interview K-SADS-PL was used to assess the symptoms of psychiatric disorders. Results Higher prevalence of psychiatric disorders was found in the PHIV+ group and the PHEU group compared to the HIV-nAgroup. Anxiety disorders and affective disorders were diagnosed most often. Prevalence of symptoms of emotional and behavioral disorders in the PHIV+ group and in the PHEU group was associated with similar sociodemographic variables (male, not living with the biological caregiver, the experience of stressful life events). Psychiatric disorders were noted more often among PHIV+ subjects whose ARV treatment was started after 12 months of age. Positive correlations were observed between the results of some YSR and CBCL/4–18 problem scales and CD4 counts at the time of the study, higher logarithm of viral load at the start of ARV treatment and at the time of HIV diagnosis. Conclusions The prevalence of psychiatric disorders in PHIV+ group and the PHEU group is higher in comparison with HIV-nAgroup. Amore serious course of HIV infection and its severity before treatment are associated with the severity of internalizing problems.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Zaburzenia psychiczne, behawioralne i emocjonalne u dzieci i młodzieży z wrodzonym zakażeniem HIV w Polsce
    URL: Article
    DOI: 10.12740/PP/OnlineFirst/121980
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2021
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  • 6
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    Online Resource
    Depression and smoking – widespread health problems among 14-year-old adolescents in Poland. The results of the SOPKARD-Junior survey
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2021
    In:  Psychiatria Polska Vol. 55, No. 1 ( 2021-2-28), p. 113-125
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 55, No. 1 ( 2021-2-28), p. 113-125
    Abstract: Assessment of prevalence and co-prevalence of depression and substance abuse among Sopot youth. Methods In the years 2006–2007, 316 subjects participated in a psychological examination as part of the SOPKARD-Junior program. The assessment was made using the Beck Depression Inventory, the Krakow Depression Inventory and a proprietary questionnaire evaluating the frequency of psychoactive substance use. Adolescents with depressive symptoms in the questionnaire study underwent a psychiatric examination. The SOPKARD-Junior program is a multidisciplinary epidemiologic study that comprehensively assesses the health of the population of 14-year-old junior secondary school students in Sopot. Results Symptoms of depression were detected in 29.4% of subjects: 37.4% of girls (G) and 20.9% of boys (B) (p 〈 0.05). In the psychiatric examination, an episode of depression was diagnosed in 4.1% of students (G: 5.5%; B: 2.6%). The rates of substance use (occasional or regular) were: cigarettes – 20.2 % of students (G: 24% and B: 16.4%; p 〈 0.05), alcohol – 45.9% (G: 50.9% and B: 40.5%; p 〈 0.05), and illicit drugs – 6.3% (G: 6.2% and B: 6.6%; n.s.). Teenagers with depressive symptoms smoke cigarettes and drink alcohol significantly more often than those without depressive symptoms (smoking rates:30.1% vs. 16.1%; p 〈 0.05; alcohol drinking rates: 61.3% vs. 39.5%; p 〈 0.05). Conclusions (1) Significant prevalence of depressive symptoms was detected among the adolescents in the study. (2) Girls smoke cigarettes and drink alcohol significantly more frequently than boys. (3) The occurrence of depressive symptoms in adolescents almost doubles the risk of tobacco and alcohol use.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Depresja i palenie papierosów – powszechne problemy zdrowotne wśród polskich 14-latków. Wyniki badania SOPKARD-Junior
    URL: Article
    DOI: 10.12740/PP/111218
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2021
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  • 7
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    Online Resource
    The prevalence of mental disorders among children and youth staying in residential institutions, children’s homes – a review of epidemiological studies
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2018
    In:  Psychiatria Polska Vol. 52, No. 2 ( 2018-4-30), p. 345-353
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 52, No. 2 ( 2018-4-30), p. 345-353
    Abstract: Emergence of mental health problems in childhood can seriously affect further development of a man and thus hamper his adaptation to adult life. Children in residential institutions may be particularly vulnerable at risk of abnormal mental development, this includes so-called ‘children’s homes’. In the article we present an overview of the few studies carried out so far in the European residential institutions, including children’s homes, over the years 1940–2011 in the UK, Germany, Romania, and Poland. Firstly, we briefly describe a classic research carried out in the world in the 1940s among children from children’s homes. Secondly, we present a study conducted in the UK among children and youth from different age groups staying in residential institutions, including children’s homes. Then we focus on studies carried out among children and adolescents form German residential institutions and on a group of preschool children from Romanian children’s homes. At the end of the article we describe the first epidemiological study carried out in Poland on the population of children and young people staying in children’s homes in Warsaw. The review of researches shows that children from day-care facilities are a population with a high prevalence of psychiatric disorder. Children and youth staying in residential institutions probably require specialized psychiatric, psychological and psychotherapeutic care.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Rozpowszechnienie zaburzeń psychicznych wśród dzieci i młodzieży przebywających w placówkach opiekuńczo-wychowawczych, domach dziecka – przegląd badań epidemiologicznych
    URL: Article
    DOI: 10.12740/PP/75738
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2018
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  • 8
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    Online Resource
    ADHD and overweight in boys: cross-sectional study with birth weight as a controlled factor
    Springer Science and Business Media LLC ; 2015
    In:  European Child & Adolescent Psychiatry Vol. 24, No. 1 ( 2015-1), p. 41-53
    Details
    In: European Child & Adolescent Psychiatry, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2015-1), p. 41-53
    Type of Medium: Online Resource
    ISSN: 1018-8827 , 1435-165X
    URL: Article
    DOI: 10.1007/s00787-014-0531-1
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 1463026-6
    SSG: 5,2
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  • 9
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    Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome
    Springer Science and Business Media LLC ; 2023
    In:  Translational Psychiatry Vol. 13, No. 1 ( 2023-02-23)
    Details
    In: Translational Psychiatry, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-02-23)
    Abstract: Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK Biobank data and applied a Phenome Wide Association Study (PheWAS) approach to determine the association of disease risk with a wide range of phenotypes. A total of 57 traits were found to be significantly associated with TS polygenic risk, including multiple psychosocial factors and mental health conditions such as anxiety disorder and depression. Additional associations were observed with complex non-psychiatric disorders such as Type 2 diabetes, heart palpitations, and respiratory conditions. Cross-disorder comparisons of phenotypic associations with genetic risk for other childhood-onset disorders (e.g.: attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD] , and obsessive-compulsive disorder [OCD]) indicated an overlap in associations between TS and these disorders. ADHD and ASD had a similar direction of effect with TS while OCD had an opposite direction of effect for all traits except mental health factors. Sex-specific PheWAS analysis identified differences in the associations with TS genetic risk between males and females. Type 2 diabetes and heart palpitations were significantly associated with TS risk in males but not in females, whereas diseases of the respiratory system were associated with TS risk in females but not in males. This analysis provides further evidence of shared genetic and phenotypic architecture of different complex disorders.
    Type of Medium: Online Resource
    ISSN: 2158-3188
    URL: Article
    DOI: 10.1038/s41398-023-02341-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2609311-X
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  • 10
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    Online Resource
    Perinatal Risk Factors and ADHD in Children and Adolescents: A Hierarchical Structure of Disorder Predictors
    SAGE Publications ; 2018
    In:  Journal of Attention Disorders Vol. 22, No. 9 ( 2018-07), p. 855-863
    Details
    In: Journal of Attention Disorders, SAGE Publications, Vol. 22, No. 9 ( 2018-07), p. 855-863
    Abstract: Objective: The aim of the study was to hierarchically assess the predictive power of low and high birth weight, pre-term and post-term birth, and low Apgar score as the risk factors for ADHD. Method: The data of 132 boys diagnosed with ADHD and 146 boys from control group, aged 6 to 18 years, have been analyzed. The boys were categorized according to term of birth, birth weight, and Apgar score. CART method (Classification and Regression Trees) was used for assessment of the relationship between perinatal factors and the risk of ADHD. Results: Low Apgar score (21.97% vs. 13.01%) and post-term birth (12.12% vs. 0.68%) were more frequent in the sample than in the control group. CART method additionally indicated low birth weight as associated with the risk of ADHD. Among analyzed risk factors, Apgar score had the highest predictive value. Conclusion: The decreased Apgar score is the most important perinatal risk factor of ADHD. Research results also indicated a high significance of post-term birth in predicting the disorder.
    Type of Medium: Online Resource
    ISSN: 1087-0547 , 1557-1246
    URL: Article
    DOI: 10.1177/1087054716643389
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2188086-4
    SSG: 5,2
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