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  • 1
    Online Resource
    Online Resource
    Antiphospholipid syndrome as a cause of ischemic brain stroke in a 20-year-old woman with secondary mood, personality disorders and anorexia nervosa traits – case report
    Termedia Sp. z.o.o. ; 2019
    In:  Neuropsychiatria i Neuropsychologia Vol. 14, No. 3-4 ( 2019), p. 92-99
    Details
    In: Neuropsychiatria i Neuropsychologia, Termedia Sp. z.o.o., Vol. 14, No. 3-4 ( 2019), p. 92-99
    Type of Medium: Online Resource
    ISSN: 1896-6764
    Uniform Title: Zespół antyfosfolipidowy jako przyczyna udaru niedokrwiennego mózgu u 20-letniej kobiety z towarzyszącymi wtórnymi zaburzeniami nastroju, osobowości oraz cechami jadłowstrętu psychicznego – opis przypadku
    URL: Article
    DOI: 10.5114/nan.2019.89794
    Language: Polish
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2019
    detail.hit.zdb_id: 3031700-9
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  • 2
    Online Resource
    Online Resource
    Correlations between negative symptoms, physical activity and metabolic syndrome in patients with schizophrenia – a literature review
    Termedia Sp. z.o.o. ; 2022
    In:  Neuropsychiatria i Neuropsychologia Vol. 17, No. 3-4 ( 2022), p. 125-131
    Details
    In: Neuropsychiatria i Neuropsychologia, Termedia Sp. z.o.o., Vol. 17, No. 3-4 ( 2022), p. 125-131
    Type of Medium: Online Resource
    ISSN: 1896-6764
    Uniform Title: Przegląd wyników badań na temat zależności pomiędzy objawami negatywnymi, aktywnością fizyczną i zespołem metabolicznym u chorych na schizofrenię
    URL: Article
    DOI: 10.5114/nan.2022.124689
    Language: Polish
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2022
    detail.hit.zdb_id: 3031700-9
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  • 3
    Online Resource
    Online Resource
    Effects of Combined Dietary Chromium(III) Propionate Complex and Thiamine Supplementation on Insulin Sensitivity, Blood Biochemical Indices, and Mineral Levels in High-Fructose-Fed Rats
    Springer Science and Business Media LLC ; 2012
    In:  Biological Trace Element Research Vol. 150, No. 1-3 ( 2012-12), p. 350-359
    Details
    In: Biological Trace Element Research, Springer Science and Business Media LLC, Vol. 150, No. 1-3 ( 2012-12), p. 350-359
    Type of Medium: Online Resource
    ISSN: 0163-4984 , 1559-0720
    URL: Article
    DOI: 10.1007/s12011-012-9515-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2012
    detail.hit.zdb_id: 2072581-4
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Laparoscopic sleeve gastrectomy: a study of efficiency in treatment of metabolic syndrome components, comorbidities and influence on certain biochemical markers
    Termedia Sp. z.o.o. ; 2020
    In:  Videosurgery and Other Miniinvasive Techniques Vol. 15, No. 1 ( 2020), p. 136-147
    Details
    In: Videosurgery and Other Miniinvasive Techniques, Termedia Sp. z.o.o., Vol. 15, No. 1 ( 2020), p. 136-147
    Type of Medium: Online Resource
    ISSN: 1895-4588
    URL: Article
    DOI: 10.5114/wiitm.2019.84718
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2020
    detail.hit.zdb_id: 2596147-0
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  • 5
    Online Resource
    Online Resource
    European Validation of the Self-Evaluation of Negative Symptoms (SNS): A Large Multinational and Multicenter Study
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychiatry Vol. 13 ( 2022-1-31)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-1-31)
    Abstract: Negative symptoms are usually evaluated with scales based on observer ratings and up to now self-assessments have been overlooked. The aim of this paper was to validate the Self-evaluation of Negative Symptoms (SNS) in a large European sample coming from 12 countries. We wanted to demonstrate: (1) good convergent and divergent validities; (2) relationships between SNS scores and patients' functional outcome; (3) the capacity of the SNS compared to the Brief Negative Symptom Scale (BNSS) to detect negative symptoms; and (4) a five-domain construct in relation to the 5 consensus domains (social withdrawal, anhedonia, alogia, avolition, blunted affect) as the best latent structure of SNS. Methods Two hundred forty-five subjects with a DSM-IV diagnosis of schizophrenia completed the SNS, the Positive and Negative Syndrome Scale (PANSS), the BNSS, the Calgary Depression Scale for Schizophrenia (CDSS), and the Personal and Social Performance (PSP) scale. Spearman's Rho correlations, confirmatory factor analysis investigating 4 models of the latent structure of SNS and stepwise multiple regression were performed. Results Significant positive correlations were observed between the total score of the SNS and the total scores of the PANSS negative subscale ( r = 0.37; P & lt; 0.0001) and the BNSS ( r = 0.43; p & lt; 0.0001). SNS scores did not correlate with the level of insight, parkinsonism, or the total score of the PANSS positive subscale. A positive correlation was found between SNS and CDSS ( r = 0.35; p & lt; 0.0001). Among the 5 SNS subscores, only avolition subscores entered the regression equation explaining a lower functional outcome. The 1-factor and 2-factor models provided poor fit, while the 5-factor model and the hierarchical model provided the best fit, with a small advantage of the 5-factor model. The frequency of each negative dimension was systematically higher using the BNSS and the SNS vs. the PANSS and was higher for alogia and avolition using SNS vs. BNSS. Conclusion In a large European multicentric sample, this study demonstrated that the SNS has: (1) good psychometric properties with good convergent and divergent validities; (2) a five-factor latent structure; (3) an association with patients' functional outcome; and (4) the capacity to identify subjects with negative symptoms that is close to the BNSS and superior to the PANSS negative subscale.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    DOI: 10.3389/fpsyt.2022.826465
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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  • 6
    Online Resource
    Online Resource
    Antioxidant and Cytotoxic Potential of Carlina vulgaris Extract and Bioactivity-Guided Isolation of Cytotoxic Components
    MDPI AG ; 2023
    In:  Antioxidants Vol. 12, No. 9 ( 2023-09-01), p. 1704-
    Details
    In: Antioxidants, MDPI AG, Vol. 12, No. 9 ( 2023-09-01), p. 1704-
    Abstract: Carlina vulgaris is a poorly understood plant in the context of biological activity, despite its widespread application in ethnomedicine in numerous European countries. The aim of this study was to assess the cytotoxic potential of the plant against human colorectal adenocarcinoma (HT29) and to isolate the plant components linked to this effect. Ultra-high performance liquid chromatography with a high-resolution/quadrupole time-of-flight mass spectrometer (UHPLC–HR/QTOF/MS–PDA) was used for the phytochemical characterization of the extract. Liquid–liquid extraction and preparative chromatography were employed for fractionation purposes. Our investigation demonstrated that the ethyl acetate fraction from C. vulgaris showed significant cytotoxicity, and a bioactivity-guided approach led to the isolation of oxylipins, including traumatic acid, pinellic acid, and 9,10-dihydroxy-8-oxsooctadec-12-enic acid. The structures of the compounds were confirmed by nuclear magnetic resonance spectroscopy. Among these compounds, the last one exhibited significant cytotoxicity, though without selectivity, and traumatic acid was characterized by mild cytotoxicity. The cytotoxicity was linked to intracellular reactive oxygen species generation.
    Type of Medium: Online Resource
    ISSN: 2076-3921
    URL: Article
    DOI: 10.3390/antiox12091704
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2704216-9
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Stages of the clinical course of schizophrenia - staging concept
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2016
    In:  Psychiatria Polska Vol. 50, No. 4 ( 2016-8-30), p. 717-730
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 50, No. 4 ( 2016-8-30), p. 717-730
    Abstract: Clinical staging is a tool useful in medical sciences. It assumes the presence of three key elements. Firstly, pathologic indices are progressing in subsequent stages. Secondly, the patients in the individual stages present similar pathological changes. Thirdly, treatment should be most effective in the earlier stages. Such model is particularly well established in the treatment of malignancies. Staging is useful here to define prognosis, to evaluate the results of treatment, facilitate the exchange and comparison of information among treatment centres. There is much data describing a similar model for mental illnesses including schizophrenia. There are two theories supporting the staging model for schizophrenia: the neurodevelopmental hypothesis and allostatic load concept. Both theories make a theoretical premise for creating the staging model for schizophrenia. We can describe at least three stages in the development of a schizophrenic illness: the prodrome, the first episode and chronic phase. Each stage is reflected by anatomical and functional changes in the brain. Therefore, a clinical staging model can describe a development of schizophrenia over time, to help selecting adequate treatments that are particularly relevant to a given stage and to show the relations between known biological markers and psychosocial risk factors and the stage of the illness.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Etapy przebiegu schizofrenii - koncepcja stagingu
    URL: Article
    DOI: 10.12740/PP/58723
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2016
    detail.hit.zdb_id: 2833968-X
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  • 8
    Online Resource
    Online Resource
    Dysfunctions of the retina and other elements of the visual system in schizophrenia
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2020
    In:  Psychiatria Polska Vol. 54, No. 4 ( 2020-8-31), p. 673-686
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 54, No. 4 ( 2020-8-31), p. 673-686
    Abstract: Schizophrenia is an illness with a large variety of symptoms, significant variability of the individual course, and still not fully explained etiology. It is suggested that genetic, infectious and immunological factors may be involved, and neurodevelopmental, neurodegenerative and neurotransmitter hypotheses have been proposed. Detection of the measurable and reproducible biological indicators of the clinical picture and the course, referred to as biomarkers, may be essential to elucidate the etiopathogenic mechanism of the illness. For schizophrenia, this function may be performed by the retina of the eye and other elements of the visual pathway. The observed abnormalities are of a structural and functional nature. They concern virtually the entire visual system, and, in accordance with the neurodevelopmental theory of schizophrenia, arise at the early stages of brain formation. What is essential – the specific structure of the human eye, its translucency, lack of myelin and low concentration of glial cells provide excellent opportunities for non-invasive assessment of the microstructure and function of the central nervous system. The following paper discusses the most important changes in the visual apparatus observed in patients with schizophrenia. Particular attention was paid to retinal vascular changes, anomalies in the electroretinogram and optical coherence tomography, structural and functional disorders of cortical centers and neurochemical disorders in the cells of the visual pathway.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Zaburzenia funkcji siatkówki i innych elementów układu wzrokowego w schizofrenii
    URL: Article
    DOI: 10.12740/PP/114952
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2020
    detail.hit.zdb_id: 2833968-X
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  • 9
    Online Resource
    Online Resource
    Polish version of the Self-evaluation of Negative Symptoms (SNS)
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2019
    In:  Psychiatria Polska Vol. 53, No. 3 ( 2019-6-30), p. 551-559
    Details
    In: Psychiatria Polska, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 53, No. 3 ( 2019-6-30), p. 551-559
    Abstract: The aim of the study was to create a Polish version of the Self-evaluation of NegativeSymptoms (SNS) scale, to assess its internal consistency, and to make correlations between the SNS scores and the Brief Negative Symptom Scale (BNSS) scores in the group of patients with schizophrenia. Material and Methods The procedure of Polish adaptation of the French-language version of the SNS scale, comprising 20 items organized in 5 subscales: asociality, blunted affect, alogia, avolition and anhedonia, was carried out. Psychometric tests were performed in 40 patients with paranoid schizophrenia (20 men and 20 women) with severity of symptoms on the Positive and Negative Syndrome Scale (PANSS) 56±16 points, receiving unchanged pharmacological treatment in the last 3 months Results The Polish version of the SNS scale was accepted by the author of the scale, Professor Sonia Dollfus. The reliability analysis showed high values of the Cronbach’s alpha coefficient for the whole scale (0.91) and for the subscales (0.61–0.85). The SNS and its subscales showed significant correlations with the total BNSS score and with the scores of the BNSS subscales, which confirms the validity of the scale Conclusions A statistically significant level of consistency of the whole scale and its individual domains with the results of the clinical assessment with the BNSS, speaks for the adequacy of the self – assessment of negative symptoms by a patient with schizophrenia. Good psychometric properties of the Polish version of the SNS obtained in the study can indicate its usefulness in the research on negative symptoms conducted in Poland.
    Type of Medium: Online Resource
    ISSN: 0033-2674 , 2391-5854
    Uniform Title: Polska wersja Skali Samooceny Objawów Negatywnych (Self-evaluation of Negative Symptoms – SNS)
    URL: Article
    DOI: 10.12740/PP/OnlineFirst/97352
    Language: Polish
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2019
    detail.hit.zdb_id: 2833968-X
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  • 10
    Online Resource
    Online Resource
    Emotion recognition and theory of mind in chronic schizophrenia: association with negative symptoms
    Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego ; 2017
    In:  Archives of Psychiatry and Psychotherapy Vol. 19, No. 4 ( 2017-12-18), p. 7-12
    Details
    In: Archives of Psychiatry and Psychotherapy, Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego, Vol. 19, No. 4 ( 2017-12-18), p. 7-12
    Abstract: Assessing a relationship between the negative symptoms and deficits in emotion recognition and theory of mind (ToM) as well as social functioning, in chronic schizophrenia patients. Subject or material and methods Twenty patients with schizophrenia (10 male, 10 female), aged 36+11 years, with mean duration of the illness of 13+9 years, were studied during improvement period, stabilized on medications for at least 3 months. For the assessment of symptoms, the Positive and Negative Symptoms Scale (PANSS) and the Brief Negative Symptoms Scale (BNSS) were used. Emotion recognition was measured by the Facial Emotion Identification Test (FEIT) and ToM - by the Reading Mind in the Eyes (R-MET) test. Patients' social functioning was evaluated by the Personal and Social Performance Scale (PSP). Results Significant correlations were obtained between the negative symptoms of PANSS and BNSS, and the results of FEIT and R-MET. Association between BNSS and FEIT was observed for anhedonia, distress, asociality, avolition, blunted affect, alogia, and with R-MET, for distress, emotional blunting and alogia. Both PANSS and BNSS negative symptoms significantly correlated with the results of PSP. Discussion The results correspond to those of recent studies showing a priority of negative over positive symptoms in determining deficits in social cognition and functioning in chronic schizophrenia. Conclusions All domains of negative symptoms assessed by the BNSS correlated with deficits in emotion recognition and of social functioning and some domains correlated with the measure of the ToM.
    Type of Medium: Online Resource
    ISSN: 1509-2046 , 2083-828X
    URL: Article
    DOI: 10.12740/APP/79878
    Language: Unknown
    Publisher: Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego
    Publication Date: 2017
    detail.hit.zdb_id: 2565784-7
    SSG: 5,2
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