In:
Chemistry – A European Journal, Wiley, Vol. 23, No. 63 ( 2017-11-13), p. 15917-15921
Abstract:
The first stereoselective total synthesis of the natural product pyrronazol B, which contains a chlorinated pyrrole–oxazole–pyrone framework, has been achieved. Genome sequencing of the myxobacterial producer strain Nannocystis pusilla Ari7 led to the identification of the putative biosynthetic gene cluster. The proposed biosynthetic pathway was supported by feeding experiments with stable isotopes of three biosynthetic building blocks, namely l ‐proline, l ‐serine, and l ‐methionine.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201703782
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1478547-X
Permalink