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  • 1
    Online Resource
    Online Resource
    Predictors of heart failure symptoms in hereditary hemorrhagic telangiectasia patients with hepatic arteriovenous malformations
    Springer Science and Business Media LLC ; 2021
    In:  Orphanet Journal of Rare Diseases Vol. 16, No. 1 ( 2021-12)
    Details
    In: Orphanet Journal of Rare Diseases, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2021-12)
    Abstract: Hepatic arteriovenous malformations (AVMs) in hereditary hemorrhagic telangiectasia (HHT) patients are most commonly hepatic artery to hepatic venous shunts which can result in high-output heart failure. This condition can be debilitating and is a leading cause of liver transplantation in HHT patients. However, it is not known what characteristics can discriminate between asymptomatic patients and those who will develop heart failure symptoms. Results 176 patients with HHT were evaluated with computed tomography angiography (CTA) between April 2004 and February 2019 at our HHT Center of Excellence. 63/176 (35.8%) patients were found to have hepatic AVMs on CTA. 18 of these patients were excluded because of the presence of another condition which could confound evaluation of heart failure symptoms. In the remaining 45 patients included in our cohort, 25/45 (55.6%) patients were classified as asymptomatic and 20/45 (44.4%) were classified as symptomatic, and these groups were compared. In symptomatic patients, mean common hepatic artery (CHA) diameter was significantly higher (11.1 versus 8.4 mm) and mean hemoglobin levels were significantly lower (10.7 vs 12.6 g/dL). A stepwise multiple logistic regression analysis demonstrated that both CHA diameter and hemoglobin level were independent predictors of heart failure symptoms with ORs of 2.554 (95% CI 1.372–4.754) and 0.489 (95% CI 0.299–0.799), respectively. The receiver operator characteristic (ROC) curve of our analysis demonstrated an AUC of 0.906 (95% CI 0.816–0.996), sensitivity 80.0% (95% CI 55.7–93.4%), and specificity 75.0% (95% CI 52.9–89.4%). Conclusions CTA is an effective and easily reproducible method to evaluate hepatic involvement of HHT. Utilizing CTA, clinical, and laboratory data we determined CHA diameter and hemoglobin level were independent predictors of heart failure symptoms.
    Type of Medium: Online Resource
    ISSN: 1750-1172
    URL: Article
    DOI: 10.1186/s13023-021-02109-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2225857-7
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  • 2
    Online Resource
    Online Resource
    Contrast-enhanced ultrasound for abdominal image-guided procedures
    Springer Science and Business Media LLC ; 2023
    In:  Abdominal Radiology Vol. 48, No. 4 ( 2023-02-28), p. 1438-1453
    Details
    In: Abdominal Radiology, Springer Science and Business Media LLC, Vol. 48, No. 4 ( 2023-02-28), p. 1438-1453
    Type of Medium: Online Resource
    ISSN: 2366-0058
    URL: Article
    DOI: 10.1007/s00261-023-03804-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2845742-0
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  • 3
    Online Resource
    Online Resource
    Analysis of Spontaneous Eyelid Blink Dynamics Using a 240 Frames per Second Smartphone Camera
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Ophthalmic Plastic & Reconstructive Surgery Vol. 35, No. 5 ( 2019-09), p. 503-505
    Details
    In: Ophthalmic Plastic & Reconstructive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 35, No. 5 ( 2019-09), p. 503-505
    Abstract: To report initial results using a native 240 frames per second smartphone camera for 2-dimensional videographic analysis of eyelid dynamics during spontaneous blinking. Methods: Spontaneous blinking was prospectively recorded in volunteers using a smartphone camera recording at 240 frames per second in 720p. A standardized recording setup was used in which the smartphone was mounted on a tripod stand at 0.5 m in the Frankfort horizontal plane. Subjects viewed a nature documentary video in primary gaze while their spontaneous blinking was recorded for 3 minutes. Exclusion criteria included known eyelid malposition or ocular surface pathology, including dry eye syndrome, contact lens use, prior eyelid or intraocular surgery, prior periocular trauma, or craniofacial abnormality. Primary outcome measures were spontaneous interblink interval, blink rate in blinks per minute, percentage of incomplete blinks, and blink velocity. Results: The authors studied 10 subjects, 5 men and 5 women. Average age was 34 (range 19–58). Mean interblink interval was found to be 7.4 seconds (SD: 5.2, range: 1.9–17.6), corresponding to a mean blink rate of 13 blinks per minute (SD: 7.8, range: 3.4–32.0). Mean percentage of incomplete blinks was 49.8% (SD: 33.3, range: 0–100). Mean blink closure velocity was 93 mm/seconds (SD: 31, range: 40–160). These numbers are consistent with previously published results of spontaneous eyelid blink parameters. Conclusions: This study demonstrates that 240 frames per second videography native to modern smartphone cameras captures anatomic detail and blink dynamics with sufficient resolution and clarity to provide objective clinical information about spontaneous eyelid blink rate, dynamics, and function.
    Type of Medium: Online Resource
    ISSN: 0740-9303
    URL: Article
    DOI: 10.1097/IOP.0000000000001356
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2070654-6
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  • 4
    Online Resource
    Online Resource
    Ab initio investigation of the surface properties of dispenser B-type and scandate thermionic emission cathodes
    AIP Publishing ; 2009
    In:  Applied Physics Letters Vol. 94, No. 18 ( 2009-05-04)
    Details
    In: Applied Physics Letters, AIP Publishing, Vol. 94, No. 18 ( 2009-05-04)
    Abstract: Scandate cathodes (BaxScyOz on W) are important thermionic electron emission materials whose emission mechanism remains unclear. Ab initio modeling is used to investigate the surface properties of both scandate and traditional B-type (Ba–O on W) cathodes. We demonstrate that the Ba–O dipole surface structure believed to be present in active B-type cathodes is not thermodynamically stable, suggesting that a nonequilibrium steady state dominates the active cathode’s surface structure. We identify a stable, low work function BaxScyOz surface structure, which may be responsible for some scandate cathode properties and demonstrate that multicomponent surface coatings can lower cathode work functions.
    Type of Medium: Online Resource
    ISSN: 0003-6951 , 1077-3118
    URL: Article
    DOI: 10.1063/1.3129193
    RVK:
    UA 1000
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2009
    detail.hit.zdb_id: 211245-0
    detail.hit.zdb_id: 1469436-0
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  • 5
    Online Resource
    Online Resource
    An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT-Bleed study
    Ferrata Storti Foundation (Haematologica) ; 2020
    In:  Haematologica Vol. 106, No. 8 ( 2020-07-16), p. 2161-2169
    Details
    In: Haematologica, Ferrata Storti Foundation (Haematologica), Vol. 106, No. 8 ( 2020-07-16), p. 2161-2169
    Abstract: Hereditary hemorrhagic telangiectasia (HHT, Osler-Weber-Rendu disease) is a rare multisystem vascular disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Bevacizumab, an anti-vascular endothelial growth factor antibody, may be effective to treat bleeding in HHT. This international, multicenter, retrospective study evaluated the use of systemic bevacizumab to treat HHT-associated bleeding and anemia at 12 HHT treatment centers. Hemoglobin, epistaxis severity score, red cell units transfused, and intravenous iron infusions before and after treatment were evaluated using paired means testing and mixed-effects linear models. 238 HHT patients received bevacizumab for a median of 12 (range, 1-96) months. Compared with pretreatment, bevacizumab increased mean hemoglobin by 3.2 g/dL (95% CI, 2.9-3.5 g/dL) [mean hemoglobin 8.6 (8.5, 8.8) g/dL versus 11.8 (11.5, 12.1) g/dL, p
    Type of Medium: Online Resource
    ISSN: 1592-8721 , 0390-6078
    URL: Article
    DOI: 10.3324/haematol.2020.261859
    Language: Unknown
    Publisher: Ferrata Storti Foundation (Haematologica)
    Publication Date: 2020
    detail.hit.zdb_id: 2186022-1
    detail.hit.zdb_id: 2030158-3
    detail.hit.zdb_id: 2805244-4
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