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  • 1
    Online Resource
    Online Resource
    Development of Drosophila wing sensory neurons in mutants with missing or modified cell surface molecules
    The Company of Biologists ; 1993
    In:  Development Vol. 117, No. 4 ( 1993-04-01), p. 1251-1260
    Details
    In: Development, The Company of Biologists, Vol. 117, No. 4 ( 1993-04-01), p. 1251-1260
    Abstract: The neurons of the sensory receptors on the wing of Drosophila melanogaster have highly characteristic axon projections in the central nervous system (CNS). The morphology of these projections was studied in flies bearing mutations that affect cell surface molecules thought to be important in axon guidance. The animals used were mutant for the fasciclinI (fasI), fasciclinII (fasII), fasciclinIII (fasIII) and neurally altered carbohy - drate (nac) genes. Axon populations were visualized by staining with DiI and light-reacting the dye with diaminobenzidine to yield permanent preparations. The fasI, fasII and fasIII mutants as well as the nac mutant display altered axonal trajectories in the CNS. One phenotype seen in fasII mutants and in animals mutant for both fasI and fasIII was extra branching within the axon projection pattern. A second phenotype observed was a reduction or complete loss of one of the tracts, apparently due to the axons shifting to a neigh-boring tract. This was seen in the most extreme form in nac mutants and to a lesser degree in fasIII mutants. To determine if the mutations discussed here affected axon guidance, wing discs were analyzed using the anti- body 22C10 to label sensory neurons in the wing during metamorphosis. Both misrouting of axons and the appearance of ectopic neurons in the wing were observed. In the fasI;fasIII, the fasII and the nac mutants, there was misrouting of sensory axons in the developing wing. In addition, the fasII and nac mutants displayed ectopic sensory neurons in the wing. This implies that the cell surface molecules missing (fasci - clins) or modified (by the nac gene product), in these mutants may play a role in both neurogenesis and axon guidance.
    Type of Medium: Online Resource
    ISSN: 0950-1991 , 1477-9129
    URL: Article
    DOI: 10.1242/dev.117.4.1251
    Language: English
    Publisher: The Company of Biologists
    Publication Date: 1993
    detail.hit.zdb_id: 2007916-3
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  • 2
    Online Resource
    Online Resource
    A New Model for Olfactory Placode Development
    S. Karger AG ; 2004
    In:  Brain, Behavior and Evolution Vol. 64, No. 3 ( 2004), p. 126-140
    Details
    In: Brain, Behavior and Evolution, S. Karger AG, Vol. 64, No. 3 ( 2004), p. 126-140
    Abstract: The peripheral nervous system of vertebrate animals arises primarily from the interaction of cranial neural crest and sensory placodes. Placodes are described as thickenings of ectoderm that arise through cell division during neural tube formation. The olfactory sensory system is one component of the peripheral nervous system that arises from paired sensory placodes during development. The olfactory placodes give rise to the primary sensory neurons, support cells and basal cells of the olfactory epithelium. Recent evidence from work in zebrafish and chick suggests that the olfactory and auditory placodes arise from large fields of cells that converge to form the sensory placode. The olfactory placodes arise from within the neural plate, and cell division is apparent only after the sensory placodes are morphologically distinct. As the olfactory placode is forming, its precursors must segregate from their neighboring fields which will give rise to the adenohypophyseal placode, cranial neural crest, and telencephalon. Analysis has shown that the endocrine cells thought to arise from the olfactory placode originate in the neighboring adenohypophyseal and cranial neural crest domains. The borders separating the domains are plastic, where cells sort as they move, and cell fate is dependent on the identity of neighbors once the cells have converged to form the sensory placode. Thus there is degeneracy built into the system such that cells accommodate changes in the environment until cell migrations controlling the formation of the sensory placodes are complete.
    Type of Medium: Online Resource
    ISSN: 0006-8977 , 1421-9743
    URL: Article
    DOI: 10.1159/000079742
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1482032-8
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    SSG: 5,2
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  • 3
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    Online Resource
    Image_2.jpeg
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-5-27)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-5-27)
    Abstract: In the vertebrate olfactory tract new neurons are continuously produced throughout life. It is widely believed that neurogenesis contributes to learning and memory and can be regulated by immune signaling molecules. Proteins originally identified in the immune system have subsequently been localized to the developing and adult nervous system. Previously, we have shown that olfactory imprinting, a specific type of long-term memory, is correlated with a transcriptional response in the olfactory organs that include up-regulation of genes associated with the immune system. To better understand the immune architecture of the olfactory organs we made use of cell-specific fluorescent reporter lines in dissected, intact adult brains of zebrafish to examine the association of the olfactory sensory neurons with neutrophils and blood-lymphatic vasculature. Surprisingly, the olfactory organs contained the only neutrophil populations observed in the brain; these neutrophils were localized in the neural epithelia and were associated with the extensive blood vasculature of the olfactory organs. Damage to the olfactory epithelia resulted in a rapid increase of neutrophils both within the olfactory organs as well as the central nervous system. Analysis of cell division during and after damage showed an increase in BrdU labeling in the neural epithelia and a subset of the neutrophils. Our results reveal a unique population of neutrophils in the olfactory organs that are associated with both the olfactory epithelia and the lymphatic vasculature suggesting a dual olfactory-immune function for this unique sensory system.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.881702
    DOI: 10.3389/fimmu.2022.881702.s001
    DOI: 10.3389/fimmu.2022.881702.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 4
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    Online Resource
    Corrigendum: The olfactory tract: Basis for future evolution in response to rapidly changing ecological niches
    Frontiers Media SA ; 2023
    In:  Frontiers in Neuroanatomy Vol. 17 ( 2023-3-23)
    Details
    In: Frontiers in Neuroanatomy, Frontiers Media SA, Vol. 17 ( 2023-3-23)
    Type of Medium: Online Resource
    ISSN: 1662-5129
    URL: Article
    DOI: 10.3389/fnana.2023.1153062
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2452969-2
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  • 5
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    Online Resource
    Changes in Olfactory Receptor Expression Are Correlated With Odor Exposure During Early Development in the zebrafish ( Danio rerio )
    Oxford University Press (OUP) ; 2016
    In:  Chemical Senses Vol. 41, No. 4 ( 2016-05), p. 301-312
    Details
    In: Chemical Senses, Oxford University Press (OUP), Vol. 41, No. 4 ( 2016-05), p. 301-312
    Type of Medium: Online Resource
    ISSN: 0379-864X , 1464-3553
    URL: Article
    DOI: 10.1093/chemse/bjw002
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2016
    detail.hit.zdb_id: 1494617-8
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  • 6
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    Online Resource
    Zebrafish Preference for Light or Dark Is Dependent on Ambient Light Levels and Olfactory Stimulation
    Mary Ann Liebert Inc ; 2011
    In:  Zebrafish Vol. 8, No. 1 ( 2011-03), p. 17-22
    Details
    In: Zebrafish, Mary Ann Liebert Inc, Vol. 8, No. 1 ( 2011-03), p. 17-22
    Type of Medium: Online Resource
    ISSN: 1545-8547 , 1557-8542
    URL: Article
    DOI: 10.1089/zeb.2010.0671
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2011
    detail.hit.zdb_id: 2156020-1
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  • 7
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    Zebrafish Invade Valparaiso: Third Meeting and Symposium of the Latin American Zebrafish Network
    Mary Ann Liebert Inc ; 2014
    In:  Zebrafish ( 2014-11-05)
    Details
    In: Zebrafish, Mary Ann Liebert Inc, ( 2014-11-05)
    Type of Medium: Online Resource
    ISSN: 1545-8547 , 1557-8542
    URL: Article
    DOI: 10.1089/zeb.2014.1050.REV
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2014
    detail.hit.zdb_id: 2156020-1
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  • 8
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    Online Resource
    Food and Conspecific Chemical Cues Modify Visual Behavior of Zebrafish, Danio rerio
    Mary Ann Liebert Inc ; 2012
    In:  Zebrafish Vol. 9, No. 2 ( 2012-06), p. 68-73
    Details
    In: Zebrafish, Mary Ann Liebert Inc, Vol. 9, No. 2 ( 2012-06), p. 68-73
    Type of Medium: Online Resource
    ISSN: 1545-8547 , 1557-8542
    URL: Article
    DOI: 10.1089/zeb.2012.0734
    Language: English
    Publisher: Mary Ann Liebert Inc
    Publication Date: 2012
    detail.hit.zdb_id: 2156020-1
    SSG: 12
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  • 9
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    Online Resource
    Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons
    The Company of Biologists ; 2015
    In:  Biology Open Vol. 4, No. 9 ( 2015-09-15), p. 1077-1086
    Details
    In: Biology Open, The Company of Biologists, Vol. 4, No. 9 ( 2015-09-15), p. 1077-1086
    Abstract: Gonadotropin-releasing hormone (GnRH) is a hypothalamic decapeptide essential for fertility in vertebrates. Human male patients lacking GnRH and treated with hormone therapy can remain fertile after cessation of treatment suggesting that new GnRH neurons can be generated during adult life. We used zebrafish to investigate the neurogenic potential of the adult hypothalamus. Previously we have characterized the development of GnRH cells in the zebrafish linking genetic pathways to the differentiation of neuromodulatory and endocrine GnRH cells in specific regions of the brain. Here, we developed a new method to obtain neural progenitors from the adult hypothalamus in vitro. Using this system, we show that neurospheres derived from the adult hypothalamus can be maintained in culture and subsequently differentiate glia and neurons. Importantly, the adult derived progenitors differentiate into neurons containing GnRH and the number of cells is increased through exposure to either testosterone or GnRH, hormones used in therapeutic treatment in humans. Finally, we show in vivo that a neurogenic niche in the hypothalamus contains GnRH positive neurons. Thus, we demonstrated for the first time that neurospheres can be derived from the hypothalamus of the adult zebrafish and that these neural progenitors are capable of producing GnRH containing neurons.
    Type of Medium: Online Resource
    ISSN: 2046-6390
    URL: Article
    DOI: 10.1242/bio.010447
    Language: English
    Publisher: The Company of Biologists
    Publication Date: 2015
    detail.hit.zdb_id: 2632264-X
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  • 10
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    Online Resource
    Video_5.MP4
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 8 ( 2021-1-18)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 8 ( 2021-1-18)
    Abstract: The immune system of vertebrates is characterized by innate and adaptive immunity that function together to form the natural defense system of the organism. During development innate immunity is the first to become functional and is mediated primarily by phagocytic cells, including macrophages, neutrophils, and dendritic cells. In the olfactory sensory system, the same sensory neurons in contact with the external environment have their first synapse within the central nervous system. This unique architecture presents a potential gateway for the entry of damaging or infectious agents to the nervous system. Here we used zebrafish as a model system to examine the development of the olfactory organ and to determine whether it shares immune characteristics of a host defense niche described in other tissues. During early development, both neutrophils and macrophages appear coincident with the generation of the primitive immune cells. The appearance of neutrophils and macrophages in the olfactory organs occurs as the blood and lymphatic vascular system is forming in the same region. Making use of the neurogenic properties of the olfactory organ we show that damage to the olfactory sensory neurons in larval zebrafish triggers a rapid immune response by local and non-local neutrophils. In contrast, macrophages, although present in greater numbers, mount a slower response to damage. We anticipate our findings will open new avenues of research into the role of the olfactory-immune response during normal neurogenesis and damage-induced regeneration and contribute to our understanding of the formation of a potential host defense immune niche in the peripheral nervous system.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcell.2020.604030
    DOI: 10.3389/fcell.2020.604030.s001
    DOI: 10.3389/fcell.2020.604030.s002
    DOI: 10.3389/fcell.2020.604030.s003
    DOI: 10.3389/fcell.2020.604030.s004
    DOI: 10.3389/fcell.2020.604030.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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