In:
Indoor and Built Environment, SAGE Publications, Vol. 12, No. 4 ( 2003-08), p. 231-233
Abstract:
A birth cohort study (LARS - Leipzig Allergy Risk Children Study) was used to investigate the influence of indoor mould exposure on T cell function in early childhood. T cell cytokines (IFN-γ, IL-4) were analysed in a sub-group of the LARS cohort (birth: n = 39, 6 months: n = 11, 12 months: n = 50, 36 months: n = 33). Mould burden was assessed by analysis of questionnaires completed at the birth of the child and measurement of indoor mould spores was carried out when the children were 3 years old. Children whose parents reported mould burden or dampness in their dwellings at the time of birth showed lower amounts of IFN-γ producing Th1 cells during the first year of life (significant at 12 months) in comparison to unexposed children. The capacity to produce IL-4 was not altered, however. When the children were 3 years old, an association between measured indoor mould and suppressed Th1 reactivity was observed. The data suggest that indoor mould exposure is associated with reduced Th1 reactivity in early childhood.
Type of Medium:
Online Resource
ISSN:
1420-326X
,
1423-0070
DOI:
10.1177/1420326X03035167
Language:
English
Publisher:
SAGE Publications
Publication Date:
2003
detail.hit.zdb_id:
1482713-X
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