In:
Acta Medica Scandinavica, Wiley, Vol. 195, No. 1-6 ( 1974-01-12), p. 365-373
Abstract:
Abstract. In 10 patients hemodynamics and renal function have been examined before and during i.v. infusion of dopamine. Oxygen consumption was unchanged, but cardiac output increased significantly on account of a significant reduction of arteriovenous oxygen difference during infusion. On an average cardiac output rose by a significant increase in heart rate and a slight rise in stroke volume. The pressures in the pulmonary artery, wedge position and end‐diastolic pressure in the left ventricle were essentially unchanged, but the systolic pressure in the left ventricle increased significantly. Systemic arteriolar resistance fell significantly, pulmonary arteriolar resistance revealed a trend to reduction. A very significant increase in dp/dt was found. Renal extraction of PAH fell slightly, PAH clearance increased significantly, while the clearance of inulin showed only a minimal rise. Renal plasma and blood flow, and the excretion of sodium in the urine, all increased significantly. There was a slight rise in urine flow and reabsorption of sodium. The results indicate that dopamine may have a favourable effect in shock, also in patients with oliguria.
Type of Medium:
Online Resource
ISSN:
0001-6101
DOI:
10.1111/joim.1974.195.issue-1-6
DOI:
10.1111/j.0954-6820.1974.tb08154.x
Language:
English
Publisher:
Wiley
Publication Date:
1974
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