In:
The Journal of Immunology, The American Association of Immunologists, Vol. 84, No. 3 ( 1960-03-01), p. 325-332
Abstract:
A report is made on the effects of x-irradiation (500 r) on the anaphylactic response of mice sensitized with bovine albumin-adjuvant emulsion and challenged with bovine albumin solution. X-irradiation given 1/12, 2, 4, 6 or 8 days before or 2, 4 or 6 days following sensitization failed to enhance the anaphylactic sensitivity when the interval between sensitization and challenge was 7 days. X-irradiation given 1/12, 2, 4, 6, 8, 10, 12 or 14 days before or 2, 4, 6 or 8 days after sensitization depressed the anaphylactic sensitivity of mice challenged 10 days after sensitization as measured by mortality incidence and changes in rectal temperatures. In general, a depressive effect of x-irradiation on the anaphylactic response was observed in mice exposed 2, 4, 6, 8 or 10 days prior to or 2 days following sensitization when challenge was made 14, 21, 28, 35 or 42 days postsensitization. An enhancement of susceptibility to fatal anaphylaxis was discernible in sensitized animals receiving x-irradiation 4 days or more following sensitization when the interval between sensitization and challenge was 14, 21 or 28 days. No effect of x-ray on mortality incidence or change in rectal temperature was observed when the interval was 35 or 42 days.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.84.3.325
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1960
detail.hit.zdb_id:
1475085-5
detail.hit.zdb_id:
3056-9
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