In:
Advanced Healthcare Materials, Wiley, Vol. 7, No. 10 ( 2018-05)
Abstract:
In this work, a novel ruthenium complex loaded monolayer layered double hydroxide (LDH) (denoted as Ru(C‐bpy) 2 /mLDH) as supramolecular nanosensor is synthesized, which is greatly exclusive to the hypoxic tumor microenvironment. The Ru(C‐bpy) 2 /mLDH ultrathin sheet displays not only enhanced luminescence lifetime compared to the parent Ru(C‐bpy) 2 alone, but also improved oxygen responsibility under an excitation of 488 or 800 nm. Moreover, the Ru(C‐bpy) 2 /mLDH is possessed of two‐photon fluorescence imaging ability under the 800 nm irradiation. In addition, the Ru(C‐bpy) 2 /mLDH can generate singlet oxygen with a high yield (φ ∆ ) of 0.28 under the 520 nm irradiation, while the φ ∆ of Ru(C‐bpy) 2 is 0.19. Therefore, the Ru(C‐bpy) 2 /mLDH can be applied as a supramolecular theranostic agent with light‐switchable cancer imaging and photodynamic therapy properties.
Type of Medium:
Online Resource
ISSN:
2192-2640
,
2192-2659
DOI:
10.1002/adhm.201701123
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2645585-7
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