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  • 1
    In: Pediatric Transplantation, Wiley, Vol. 27, No. 5 ( 2023-08)
    Abstract: Posttransplant lymphoproliferative disease (PTLD) is a serious complication after pediatric liver transplantation (pLT), which may lead to death. 18 F‐FDG PET/CT is rarely considered in PTLD after pLT and lacks clear diagnostic guidelines, especially in the differential diagnosis of nondestructive PTLD. The aim of this study was to find a quantifiable 18 F‐FDG PET/CT index to identify nondestructive PTLD after pLT. Methods This retrospective study collected the data of patients who underwent pLT, postoperative lymph node biopsy, and 18 F‐FDG PET/CT at Tianjin First Central Hospital from January 2014 to December 2021. Quantitative indexes were established using lymph node morphology and the maximum standardized uptake value (SUVmax). Results A total of 83 patients met the inclusion criteria and were included in this retrospective study. To distinguish between PTLD‐negative cases and nondestructive PTLD cases, according to the receiver operating characteristic curve, (the shortest diameter of the lymph node at the biopsy site [SDL]/the longest diameter of the lymph node at the biopsy site [LDL] )*(SUVmax at the biopsy site [SUVmaxBio]/SUVmax of the tonsils [SUVmaxTon] ) had the maximum area under the curve (0.923; 95% confidence interval: 0.834–1.000), and the cutoff value was 0.264 according to the maximum value of Youden's index. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 93.6%, 94.7%, 97.8%, 85.7%, and 93.9%, respectively. Conclusions (SDL/LDL)*(SUVmaxBio/SUVmaxTon) has good sensitivity, specificity, positive predictive and negative predictive values, and accuracy, and can be used as a good quantitative index for the diagnosis of nondestructive PTLD.
    Type of Medium: Online Resource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008614-3
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  • 2
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 11 ( 2023-4-11)
    Abstract: Donor shortage is an important limitation of liver transplantation (LT). Split liver transplantation (SLT) may increase the sources of donors and reduce the problem of organ shortage. However, there are no standard criteria of the selection of SLT donor, especially regarding the donor age. Methods We retrospectively analyzed the clinical data of children who received initial SLT between January 2015 and December 2021. Based on the age of donors, the patients were divided into groups A (1–10 years old; n  = 26), B (10–45 years old; n  = 87), and C (45–55 years old; n  = 27). The short-term ( & lt;1 year after SLT) outcomes of the recipients were analyzed. Results A total of 140 patients received SLT from 122 donors. The 1-, 3- and 12-month patient survival rates in group A were 100.0%, and the graft survival rates were 92.3%. The 1-, 3- and 12-month survival rates of patient and graft in group B were 97.7%, 96.6%, and 95.0%, respectively, and in group C were 85.2%, 85.2%, and 81.1%, respectively. The patient survival rate was significantly lower in group C than in groups A and B ( p  = 0.0082). There was no significant difference in graft survival between the three groups ( p  = 0.0545). Conclusions Similar results were obtained for pediatric SLT with donors & lt;10 years old and 10–45 years old. Pediatric SLT can be performed with older donors (45–55 years) after strict donor selection and selection of appropriate recipients.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711999-3
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  • 3
    In: Liver Transplantation, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 6 ( 2023-06), p. 607-617
    Type of Medium: Online Resource
    ISSN: 1527-6465
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2002186-0
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Pediatrics Vol. 10 ( 2022-6-3)
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 10 ( 2022-6-3)
    Abstract: Late-onset acute cellular rejection (LACR) is a special type of acute rejection (AR) only rarely studied after pediatric liver transplantation (pLT). Our study aimed to explore the influencing factors of LACR after pLT and establish a nomogram to provide an individualized prediction of LACR after pLT. Materials and Methods Data from 640 children who underwent pLT at Tianjin First Central Hospital from January 2016 to December 2019 were collected as part of this retrospective study. The nomogram was then established through the results of the multivariable analysis. Results Forty-one patients experienced LACR & gt; 1 ≤ 2 years after pLT. Cold ischemia time, donor-specific antibodies (DSAs), and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.834 (95% confidence interval, 0.755–0.912). Ten-fold cross-validation showed that the accuracy of the nomogram was about 76%. Sixty-three patients experienced LACR & gt; 2 years after pLT. Child–Pugh grade, cold ischemic time, DSAs, early acute cellular rejection, and tacrolimus concentration were independent influencing factors, and a nomogram was established with an AUC value of 0.827 (95% confidence interval, 0.774–0.881). Ten-fold cross-validation showed that the accuracy of the nomogram was about 80.9%. Conclusion We established nomograms to predict the incidence of LACR & gt; 1 ≤ 2 and & gt; 2 years after pLT, respectively. The verification results showed that nomograms had good accuracy and clinical practicability.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711999-3
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  • 5
    In: Surgery, Elsevier BV, Vol. 173, No. 2 ( 2023-02), p. 537-543
    Type of Medium: Online Resource
    ISSN: 0039-6060
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2018278-8
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  • 6
    In: Advanced Functional Materials, Wiley, Vol. 30, No. 12 ( 2020-03)
    Abstract: NiPS 3 , one of the most promising catalysts among transition metal trichalcogenidophosphates (MTPs) in hydrogen evolution reaction (HER) electrocatalysis, is still inhibited by its unsatisfactory activity originating from its semiconducting nature and inert basal plane. Here, it is proposed, for the first time, to engineer the basal surface activity of NiPS 3 by nonmetal heteroatom doping, and predict that the degree to which the valance band of NiPS 3 is filled dominates not only the electrical conductivity of the catalyst, but also the strength of hydrogen adsorption at its surface. Direct experimental evidence is offered that in all the single nonmetal doping samples, C‐doped NiPS 3 exhibits the optimum activity owing to its moderate filled state of valance band and that C, N codoping even shows Pt‐like activity with an ultralow overpotential of 53.2 mV to afford 10 mA cm −2 current density and a high exchange current density of 0.7 mA cm −2 in 1 m KOH. The findings that less valance electrons of dopants than substitutional atoms are of pivotal importance for improving HER activity of NiPS 3 catalyst pave the way for readily designing novel MTPs of ever high performance to replace the incumbent Pt‐based catalysts.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 7
    In: Journal of Sensors, Hindawi Limited, Vol. 2022 ( 2022-5-4), p. 1-18
    Abstract: This paper proposed an effective method, the overflow control strategy, for identifying and controlling the frequent overflow of signalized intersections based on the unmanned aerial vehicle (UAV) remote sensing and vehicle trajectory data that provide multi-dimensional vehicle dynamic data. This strategy can effectively control the overflow intersection and restore normal operation as soon as possible. The strategy was implemented as follows. First, UAV remote sensing was used to quickly find the overflow precursor at the intersection. Second, by using moving trajectory data, the second-flow model of the road section was constructed, and overflow identification indexes were established. Third, considering the traffic demand of controlled intersection and non-overflow phase from the global perspective, the queue length model of the non-overflow phase based on moving trajectory data was established and overflow identification indexes were taken as the objective function to design overflow control strategy set. Finally, according to the sampling rate requirement of moving trajectory data and the field traffic survey, the Changping District in Beijing, which meets the requirements, is selected as the case study for simulation and verification. Usually, when overflow occurs, total delay time and the average number of stop cycles at intersections are relatively high. However, by taking the proposed method, overflow at intersections was identified quickly, and a control strategy was implemented immediately, which alleviated the overflow and eventually eliminated it. The results show that the method proposed in this paper can accurately detect the occurrence of overflow, restrain and eliminate the overflow eventually.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397931-8
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  • 8
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 11 ( 2023-3-30)
    Abstract: There are subclinical cardiac abnormalities (SCA) in children with biliary atresia (BA). However, data on the consequences of these cardiac changes after liver transplantation (LT) remain controversial in the pediatric field. We aimed to determine the relationship between outcomes and the subclinical cardiac abnormalities in pediatric patients with BA based on two-dimensional echocardiography (2DE) parameters. Methods A total of 205 children with BA were enrolled in this study. The relationship between 2DE parameters and outcomes, including death and serious adverse events (SAE) after LT, was analyzed by regression analysis. Using receiver operator characteristic (ROC) curves to determine the optimal cut-off values of 2DE parameters for outcomes. Differences in the AUCs were compared using DeLong's test. The Kaplan -Meier method with log-rank testing was used to evaluate survival outcomes between groups. Results Left ventricular mass index (LVMI) and relative wall thickness (RWT) were found to be independently associated with SAE (OR: 1.112, 95% CI: 1.061 − 1.165, P   & lt; 0.001 and OR: 1.193, 95% CI: 1.078 − 1.320, P = 0.001, respectively). The cutoff value of LVMI for predicting the SAE was 68 g/m2.7 (AUC = 0.833, 95% CI 0.727-0.940, P  & lt; 0.001), and the cutoff value of RWT for predicting the SAE was 0.41 (AUC = 0.732, 95% CI 0.641-0.823, P  & lt; 0.001). The presence of subclinical cardiac abnormalities (LVMI  & gt; 68 g/m2.7, and/or RWT  & gt; 0.41) was associated with lower patient survival (1-year, 90.5% vs 100.0%; 3-year, 89.7% vs 100.0, log-rank P = 0.001). and higher incidence of SAE events. Conclusions Subclinical cardiac abnormalities were correlated with post-LT mortality and morbidity in children with BA. LVMI can predict the occurrence of death and serious adverse events after liver transplantation.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2711999-3
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  • 9
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 2013
    In:  Analytical Methods Vol. 5, No. 17 ( 2013), p. 4430-
    In: Analytical Methods, Royal Society of Chemistry (RSC), Vol. 5, No. 17 ( 2013), p. 4430-
    Type of Medium: Online Resource
    ISSN: 1759-9660 , 1759-9679
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2013
    detail.hit.zdb_id: 2515210-5
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  • 10
    In: Pediatric Transplantation, Wiley, Vol. 28, No. 1 ( 2024-02)
    Abstract: Liver transplantation (LT) is a serious cardiovascular stressor for patients with end‐stage liver disease (ESLD). Data on the effects of cardiovascular diseases on pediatric LT is limited. No study on LT for pediatric patients with ESLD combined with congenital heart disease (CHD) has been reported from mainland China. Methods A total of 1005 patients were included in this study. The Kaplan–Meier method with log‐rank testing was used to evaluate survival outcomes between groups. Univariable and multivariable Cox regression models were used to determine the risk factors for patient and graft survival. Results The most common indication for LT was biliary atresia (BA 90.3%). The prevalence of CHD was 3.8% (38). 42 CHD were found in 38 patients. The incidence of death and graft loss was more common in the CHD group than in the no‐CHD group (13.2% vs. 5.0%, p = .045 and 15.8% vs. 6.2%, p = .019, respectively). The 5‐year patient survival and graft survival in the CHD group versus the no‐CHD group was 86.8% versus 94.7% (log‐rank p = .022) and 84.2% versus 93.5% (log‐rank p = .015), respectively. No significant differences were observed in re‐transplantation, hepatic artery thrombosis (HAT), and portal vein thrombosis (PVT). After adjusting for age, BMI, etiology of LT, and other confounding factors, we can still find that the presence of CHD was associated with patient and graft survival after LT. Conclusion The presence of CHD was associated with higher mortality and lower graft survival after LT. If possible, the cardiac defects should be addressed prior to LT.
    Type of Medium: Online Resource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2008614-3
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