In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 64, No. suppl_1 ( 2014-09)
Abstract:
Background: A low-sodium (Na), high-potassium (K) diet is recommended to suppress blood pressure elevation, but determining the absolute amounts of Na and K in a diet is difficult. A novel portable device was developed to allow easy measurement of urinary Na/K ratio on the spot. In this study, our aims were 1): to observe the changes of urinary Na/K ratio in subjects on low- and high-Na diet and 2): to determine if there are differences in urinary Na/K ratio between subjects with and without salt sensitivity. Methods: Healthy volunteers (14 subjects) ingested standardized low- (3 g NaCl /day) and high-Na (20 g NaCl/day) meals for 7 days each. Urinary Na/K ratio was measured at each voiding using a prototype device (Omron Healthcare). Collection of blood and 24-hour urine was conducted at the end of each diet period (unrestricted (NS), low-salt (LS), and high-salt (HS)). Those with mean blood pressure difference (LS vs. HS) ≥ 5% were determined as salt-sensitive (SS) and others salt-resistant (SR). Results: Urinary Na/K ratio reached a plateau approximately 3 days after each change in the Na level of the diet. Urinary Na/K ratio of spot urine correlated well with Na/K ratio of 24-hour urine. Average urinary Na/K ratio was 3.9 ± 1.9 on the last day of NS, 0.8 ± 0.3 on LS, and 6.9 ± 2.1 on HS. The variation of urinary Na/K ratio was small during the LS diet period. The change in urinary Na/K ratio of SS group tended to be slower than that of SR. This device may also be useful in diabetic and proteinuric patients as Na/K ratio was affected minimally by experimental glucose and protein addition. Conclusion: Using an easy-to-use device, measurements of urinary Na/K ratio keenly reflected the sodium level of the diet.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/hyp.64.suppl_1.072
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2014
detail.hit.zdb_id:
2094210-2
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