In:
Frontiers in Public Health, Frontiers Media SA, Vol. 12 ( 2024-3-27)
Abstract:
To investigate the causal relationships between pneumoconiosis and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and gout. Methods The random-effects inverse variance weighted (IVW) approach was utilized to explore the causal effects of the instrumental variables (IVs). Sensitivity analyses using the MR-Egger and weighted median (WM) methods were did to investigate horizontal pleiotropy. A leave-one-out analysis was used to avoid the bias resulting from single-nucleotide polymorphisms (SNPs). Results There was no causal association between pneumoconiosis and SLE, RA or gout in the European population [OR = 1.01, 95% CI: 0.94–1.10, p = 0.74; OR = 1.00, 95% CI: 0.999–1.000, p = 0.50; OR = 1.00, 95% CI: 1.000–1.001, p = 0.55]. Causal relationships were also not found in pneumoconiosis due to asbestos and other mineral fibers and SLE, RA and gout [OR = 1.01, 95% CI: 0.96–1.07, p = 0.66; OR = 1.00, 95% CI: 1.00–1.00, p = 0.68; OR = 1.00, 95% CI: 1.00–1.00, p = 0.20]. Conclusion Our study suggests that pneumoconiosis may have no causal relationship with the three inflammatory immune diseases.
Type of Medium:
Online Resource
ISSN:
2296-2565
DOI:
10.3389/fpubh.2024.1373044
DOI:
10.3389/fpubh.2024.1373044.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2024
detail.hit.zdb_id:
2711781-9
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