In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 21, No. 6 ( 2017-06), p. 1106-1116
Abstract:
Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because of genetic susceptibility and environmental risk factors. To identify the genetic variants associated with MetS and metabolic components, we conducted a genome‐wide association study followed by replications in totally 12,720 participants from the north, north‐eastern and eastern China. In combined analyses, independent of the top known signal at rs651821 on APOA 5, we newly identified a secondary triglyceride‐associated signal at rs180326 on BUD 13 ( P combined = 2.4 × 10 −8 ). Notably, by an integrated analysis of the genotypes and the serum levels of APOA 5, BUD 13 and triglyceride, we observed that BUD 13 was another potential mediator, besides APOA 5, of the association between rs651821 and serum triglyceride. rs671 ( ALDH 2 ), an east Asian‐specific common variant, was found to be associated with MetS ( P combined = 9.7 × 10 −22 ) in Han Chinese. The effects of rs671 on metabolic components were more prominent in drinkers than in non‐drinkers. The replicated loci provided information on the genetic basis and mechanisms of MetS and metabolic components in Han Chinese.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2017.21.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2076114-4
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