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  • 1
    Online Resource
    Online Resource
    Extended lamivudine consolidation therapy in hepatitis B e antigen-positive chronic hepatitis B patients improves sustained hepatitis B e antigen seroconversion
    Informa UK Limited ; 2010
    In:  Scandinavian Journal of Gastroenterology Vol. 45, No. 1 ( 2010-01), p. 75-81
    Details
    In: Scandinavian Journal of Gastroenterology, Informa UK Limited, Vol. 45, No. 1 ( 2010-01), p. 75-81
    Type of Medium: Online Resource
    ISSN: 0036-5521 , 1502-7708
    URL: Article
    DOI: 10.3109/00365520903394550
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2010
    detail.hit.zdb_id: 1492631-3
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  • 2
    Online Resource
    Online Resource
    Chronic Obstructive Pulmonary Disease Increases the Risk of Hip Fracture: A Nationwide Population-Based Cohort Study
    Springer Science and Business Media LLC ; 2016
    In:  Scientific Reports Vol. 6, No. 1 ( 2016-03-18)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-03-18)
    Abstract: Hip fractures can lead to functional disability and high mortality rates among elderly patients. The aim of this study was to investigate whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture. A retrospective population-based 4-year cohort study was conducted using case–control matched analysis of data from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). Patients with a diagnosis of COPD between January 1, 2004 and December 31, 2007 were enrolled. A 2-stage approach and data from the National Health Interview Survey 2005 were applied to adjust for missing confounders in the LHID2005 cohort. Hazard ratios (HRs) and adjusted HRs were estimated hip fracture risk for the COPD. We enrolled 16,239 patients in the COPD cohort and 48,747 (1:3) patients in non-COPD cohort. The hip fracture incidences were 649 per 100,000 person-years in the study cohort and 369 per 100,000 person-years in non-COPD cohort. The hip fracture HR during the follow-up period was 1.78 ( P   〈  0.001) and the adjusted hip fracture HR was 1.57 ( P   〈  0.001) after adjustment for covariates by using the 2-stage approach method. Patients with COPD were at hip fracture risk and fracture-prevention strategies are essential for better quality of care.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep23360
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 3
    Online Resource
    Online Resource
    Changes in Intraocular Pressure after Transepithelial Photorefractive Keratectomy and Femtosecond Laser In Situ Keratomileusis
    Hindawi Limited ; 2021
    In:  Journal of Ophthalmology Vol. 2021 ( 2021-3-10), p. 1-10
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2021 ( 2021-3-10), p. 1-10
    Abstract: Purpose. To investigate the changes in intraocular pressure (IOP) and biomechanically corrected IOP (bIOP) in patients undergoing transepithelial photorefractive keratectomy (TPRK) and femtosecond laser in situ keratomileusis (FS-LASIK) and to determine the effects of preoperative biomechanical factors on IOP and bIOP changes after FS-LASIK and TPRK. Design. A retrospective comparative study. Methods. We retrospectively investigated the IOP and corneal biomechanical changes in 93 eyes undergoing FS-LASIK and 104 eyes undergoing TPRK in a clinical setting. Preoperative and postoperative data on ophthalmic and Corvis ST examinations, in vivo Young’s modulus, and noncontact tonometry were analyzed. Marginal linear regression models with generalized estimating equations were used for intragroup and intergroup comparisons of IOP and bIOP changes. Results. In the univariate model, IOP reduction after FS-LASIK was 2.49 mmHg higher than that after TPRK. In addition, bIOP reduction after FS-LASIK was 1.85 mmHg higher than that after TPRK. In the multiple regression model, we revealed that IOP reduction after FS-LASIK was 1.75 mmHg higher than that after TPRK. Additionally, bIOP reduction after FS-LASIK was 1.64 mmHg higher than that after TPRK. Postoperative changes in bIOP were less than those in IOP. In addition, Young’s modulus and CBI had no significant effect on postoperative IOP and bIOP changes. We establish a biomechanically predictive model using the available data to predict postoperative IOP and bIOP changes after TPRK and FS-LASIK. Conclusions. Reductions in IOP and bIOP after FS-LASIK were 1.75 mmHg and 1.64 mmHg, respectively, more than those after TPRK, after adjustment for confounders. We revealed that the type of refractive surgery and peak distance (PD) were significant predictors of postoperative IOP and bIOP changes. By contrast, depth of ablation showed a significant effect on only IOP changes.
    Type of Medium: Online Resource
    ISSN: 2090-0058 , 2090-004X
    URL: Article
    DOI: 10.1155/2021/5592195
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2546525-9
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  • 4
    Online Resource
    Online Resource
    Antireflective and Self-Cleaning Properties of SiO2-MgF2/TiO2 Double-Layer Films Prepared by Sol-Gel Method at Low Calcination Temperature
    Springer Science and Business Media LLC ; 2017
    In:  MRS Advances Vol. 2, No. 14 ( 2017-03), p. 777-782
    Details
    In: MRS Advances, Springer Science and Business Media LLC, Vol. 2, No. 14 ( 2017-03), p. 777-782
    Type of Medium: Online Resource
    ISSN: 2059-8521
    URL: Article
    DOI: 10.1557/adv.2017.110
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2858562-8
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  • 5
    Online Resource
    Online Resource
    Long-term neurotoxic effects of dimethylamine borane intoxication
    Elsevier BV ; 2012
    In:  Journal of the Neurological Sciences Vol. 319, No. 1-2 ( 2012-8), p. 147-151
    Details
    In: Journal of the Neurological Sciences, Elsevier BV, Vol. 319, No. 1-2 ( 2012-8), p. 147-151
    Type of Medium: Online Resource
    ISSN: 0022-510X
    URL: Article
    DOI: 10.1016/j.jns.2012.05.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 1500645-1
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  • 6
    Online Resource
    Online Resource
    Balance and gait performance in older adults with early-stage cognitive impairment
    Edizioni Minerva Medica ; 2021
    In:  European Journal of Physical and Rehabilitation Medicine Vol. 57, No. 4 ( 2021-09)
    Details
    In: European Journal of Physical and Rehabilitation Medicine, Edizioni Minerva Medica, Vol. 57, No. 4 ( 2021-09)
    Type of Medium: Online Resource
    ISSN: 1973-9087 , 1973-9095
    URL: Article
    DOI: 10.23736/S1973-9087.20.06550-8
    Language: English
    Publisher: Edizioni Minerva Medica
    Publication Date: 2021
    detail.hit.zdb_id: 2485892-4
    SSG: 31
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  • 7
    Online Resource
    Online Resource
    996 Disease Characteristics of Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  American Journal of Gastroenterology Vol. 114, No. 1 ( 2019-10), p. S578-S578
    Details
    In: American Journal of Gastroenterology, Ovid Technologies (Wolters Kluwer Health), Vol. 114, No. 1 ( 2019-10), p. S578-S578
    Abstract: Acute Hepatic Porphyria (AHP) is a family of rare genetic diseases due to enzyme deficiencies in heme biosynthesis in the liver that can lead to neurovisceral attacks and chronic symptoms. (1, 2) AHP is also associated with multiple long-term complications, including neuropathy (3,4), hypertension (5,6), chronic kidney disease (7), and hepatocellular carcinoma (8,9). METHODS: ENVISION (NCT03338816) was a Phase 3 global, multicenter, randomized, double-blind, placebo-controlled trial with an open label extension to evaluate the efficacy and safety of subcutaneous givosiran in AHP. Eligible patients had an AHP diagnosis and ≥2 attacks within the prior 6 months. At baseline detailed medical history and laboratory assessments were obtained. RESULTS: Ninety-four AHP patients enrolled, median (range) age 37.5 (19-65) years, 89% female, and median (range) of 6.5 (0.1–43) years since diagnosis. Patients had a median of 4 composite attacks in the preceding 6 months and 40% were on hemin prophylaxis prior to study. Half the patients experienced daily chronic symptoms and 29% used opioids daily/most days between attacks. Comorbidities reported on medical history included neuropathy (38%), central venous access complications (71%), iron overload (33%), liver disease (28%), and chronic kidney disease (18%). At baseline 17% of patients had liver transaminases 〉 ULN and 34% had an eGFR 〈 60 mL/min/1.73m2. CONCLUSION: The baseline disease characteristics of the Phase 3 study population are consistent with findings reported in the AHP literature, underscoring the high rate of liver disease and central venous access complications in these patients, and highlighting the multi-systemic nature of AHP and the medical challenge it presents for diagnosis and treatment.
    Type of Medium: Online Resource
    ISSN: 0002-9270 , 1572-0241
    URL: Article
    DOI: 10.14309/01.ajg.0000593520.44985.d3
    RVK:
    XA 18920
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
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  • 8
    Online Resource
    Online Resource
    The effects of surface neuromuscular electrical stimulation on post-stroke dysphagia: a systemic review and meta-analysis
    SAGE Publications ; 2016
    In:  Clinical Rehabilitation Vol. 30, No. 1 ( 2016-01), p. 24-35
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 30, No. 1 ( 2016-01), p. 24-35
    Abstract: In this study, we intended to evaluate whether swallow treatment with neuromuscular electrical stimulation is superior to that without neuromuscular electrical stimulation, and whether neuromuscular electrical stimulation alone is superior to swallow therapy. Methods: We searched the PubMed and Scopus databases from their earliest record to 31 December 2014 for randomized and quasi-randomized controlled trials that used neuromuscular electrical stimulation to treat post-stroke dysphagia. The Jadad scale was used to assess the quality of the included studies. We extracted the mean differences and standard deviation (SD) between baseline and posttreatment or posttreatment mean and SD for selected outcomes measured in the experimental and control groups for subsequent meta-analyses. Results: Eight studies were identified. For the comparison “swallow treatment with neuromuscular electrical stimulation vs. swallow treatment without neuromuscular electrical stimulation,” we found a significant standardized mean difference (SMD) of 1.27 (95% confidence interval (CI) = 0.51–2.02, P = 0.001) with significant heterogeneity ( I 2  = 85%). The meta-analysis for the comparison of neuromuscular electrical stimulation alone and swallow therapy demonstrated a non-significant SMD of 0.25 (95% CI = –0.16–0.65, P = 0.23) without significant heterogeneity ( I 2  = 16%). Conclusion: Swallow treatment with neuromuscular electrical stimulation seems to be more effective than that without neuromuscular electrical stimulation for post-stroke dysphagia in the short term considering the limited number of studies available. Evidence was insufficient to indicate that neuromuscular electrical stimulation alone was superior to swallow therapy.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215515571681
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2028323-4
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  • 9
    Online Resource
    Online Resource
    Effect of Institutional Trust on Consumers’ Health and Safety Perceptions and Repurchase Intention for Traceable Fresh Food
    MDPI AG ; 2021
    In:  Foods Vol. 10, No. 12 ( 2021-11-23), p. 2898-
    Details
    In: Foods, MDPI AG, Vol. 10, No. 12 ( 2021-11-23), p. 2898-
    Abstract: Numerous food safety incidents have gained public attention and motivated consumers to seek safer and healthier products. Some governments have responded by enacting legislation to regulate the traceability of agricultural products and enhance food safety. To elucidate factors that affect consumers’ health and safety perceptions and repurchase intention for certified traceable fresh food, this study applied institutional trust theory to explore the effects of institutional trust (i.e., trust in government, certification organizations, producers, and retailers) on consumers’ food safety and health perceptions and repurchase intention. This study was conducted in Taiwan and enrolled 393 consumers who purchased certified traceable fresh food as survey participants. Structural equation modeling and multiple and stepwise regression analysis were performed for data analysis. The results indicated that trust in government, certification organizations, food producers, and food retailers was positively related to food safety perception; trust in certification organizations, food producers, and food retailers directly influenced food healthiness perception, whereas trust in government did not have a direct influence. Furthermore, trust in certification organizations and food producers influenced repurchase intention, whereas trust in government and food retailers did not. Based on these results, the current study provides some practical suggestions for traceable fresh food marketers to use institutional trust to improve consumers’ food health and safety perceptions and repurchase intention.
    Type of Medium: Online Resource
    ISSN: 2304-8158
    URL: Article
    DOI: 10.3390/foods10122898
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704223-6
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  • 10
    Online Resource
    Online Resource
    Simulation-based holistic education in physiotherapy interns to increase empathy toward older adults and individuals with disabilities
    Springer Science and Business Media LLC ; 2022
    In:  BMC Geriatrics Vol. 22, No. 1 ( 2022-10-12)
    Details
    In: BMC Geriatrics, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-10-12)
    Abstract: The proportion of older adults and individuals with disabilities in the general population increases each year. Thus, clinical clerkships designed for physiotherapy interns should provide more than simply knowledge and skills. For such interns to be able to handle the requirements of their future jobs, clerkships must enable them to develop empathy and positive attitudes toward patients. This study investigated the effect of simulation-based, holistic health-care education on physiotherapy interns’ empathy, attitudes, and knowledge.  Methods A parallel-group design. Thirty physiotherapy interns from a medical institution were enrolled as participants, with experimental and control groups each comprising 15 participants. Both groups received standard clinical training. However, the experimental group received an additional 3.5 h of simulation-based holistic health-care education. The Jefferson Scale of Empathy, Kogan’s Attitudes Toward Old People Scale, the Attitudes Towards the Elderly Scale, the Knowledge About Aging Scale, Knowledge of the Situation of Older People Scale, Perceptions of Working with Older People Scale, and Care Willingness Scale were used in a pretest and posttest. Results After the intervention period, we observed substantial between-group differences of 6.4 points on the Jefferson Scale of Empathy ( p  = 0.001), 7.7 points on Kogan’s Attitudes Toward Old People Scale ( p  = 0.002), 3.5 points on the Attitudes Toward the Elderly Scale ( p  = 0.002), 2.5 points on Knowledge About Aging ( p  = 0.055), 4.5 points on the Knowledge of the Situation of Older People Scale ( p   〈  0.001), and 2.1 points on Perceptions of Working with Older People Scale ( p  = 0.046). Conclusion Simulation-based, holistic health-care education can significantly improve the empathy, knowledge, and attitudes of physiotherapy interns.
    Type of Medium: Online Resource
    ISSN: 1471-2318
    URL: Article
    DOI: 10.1186/s12877-022-03500-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2059865-8
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