In:
Journal of Cellular and Molecular Medicine, Wiley, Vol. 13, No. 8b ( 2009-08-02), p. 1765-1774
Abstract:
T regulatory cells (Treg) have the capability to suppress the skewed immune response, but the generation of antigen (Ag)‐specific Treg for therapeutic purpose is a challenge; the mechanism of Ag‐specific Treg activation remains obscure. Here, we report that glucuronoxylomannan (GXM) is capable of promoting the development of human tolerogenic dendritic cells (DC). GXM‐pulsed DCs increased the expression of forkhead box P3 (Foxp3) in naïve human CD4 + CD25 − T cells via activating Fc γ receptor IIb and activator protein‐1 and promoting the expression of transforming growth factor β in dendritic cells. Furthermore, the conjugated complex of house dust mite Ag, Dermatophagoides pteronyssinus (Der p) 1, and GXM‐pulsed DCs to drive the naïve human CD4 + CD25 − T cells to develop into the Der p 1‐specific Tregs, which efficiently suppressed the Ag‐specific Th2 responses. We conclude that GXM‐conjugated specific Ag have the capacity to up‐regulate the tolerogenic property of DCs and promote the generation of Ag‐specific Tregs; the latter can be activated upon the re‐exposure to specific Ag and suppress the skewed Ag‐specific T helper (Th)2 responses.
Type of Medium:
Online Resource
ISSN:
1582-1838
,
1582-4934
DOI:
10.1111/jcmm.2009.13.issue-8b
DOI:
10.1111/j.1582-4934.2008.00583.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2076114-4
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